Results 151 to 160 of about 26,505 (243)
Regulation of autophagic proteolysis by the N-recognin SQSTM1/p62 of the N-end rule pathway
, 2018 In macroautophagy/autophagy, cargoes are collected by specific receptors, such as SQSTM1/p62 (sequestosome 1), and delivered to phagophores for lysosomal degradation.
Hyunjoo Cha-Molstad +21 more
core +1 more source
Ubiquitin-induced phase separation of p62/SQSTM1 [PDF]
Cell Research, 2018 Lina, Herhaus, Ivan, Dikic
openaire +2 more sources
Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.ABSTRACT Extracellular vesicles (EVs) serve as conduits for intercellular communication, under both physiological and pathological contexts. During disease pathogenesis, microglia‐derived EVs (MEVs) play a key role in transferring pathological cargo to the recipient cells, thereby modulating their phenotype and function.
Seema Singh +5 more
wiley +1 more source
Liver International Communications, Volume 7, Issue 2, June 2026.ABSTRACT Background Post‐hepatectomy liver failure (PHLF) remains a limitation in the surgical treatment of liver cancer. The 90% partial hepatectomy (PH) rat model reliably induces biochemical PHLF and high mortality, providing a unique platform for identifying molecular pathways necessary for successful liver regeneration.
Andrea Lund +4 more
wiley +1 more source
Molecular Nutrition &Food Research, Volume 70, Issue 11, 15 June 2026.Tectochrysin (TEC) activates Foxo3a/Pink1/Parkin‐mediated mitophagy in intestinal epithelial cells, restoring mitochondrial homeostasis and reducing ROS, thereby ameliorating AOM/DSS‐induced colitis‐associated colon cancer (CAC) in mice. ABSTRACT Tectochrysin (TEC), a natural flavonoid, has shown efficacy in ameliorating chronic colitis.
Jikai He +4 more
wiley +1 more source
MyGene2 automated match report: SQSTM1
, 2016 MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If
openaire +1 more source
The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 2, June 2026.Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao +4 more
wiley +1 more source
Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek +3 more
wiley +1 more source
Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies
VIEW, Volume 7, Issue 3, June 2026.This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li +5 more
wiley +1 more source