Results 161 to 170 of about 28,326 (246)

Mitochondrial Transplantation Rejuvenates Aging Heart by Restoring Mitophagy Flux via the HIF‐3α‐BNIP3 Axis

Aging Cell, Volume 25, Issue 10, October 2026.
Aging heart shows mitophagy flux congestion and mitochondrial dysfunction. Aberrant activation of the HIF‐3α‐BNIP3 axis induces mitophagy flux congestion in the aging heart. Mitochondrial transplantation rectifies the HIF‐3α‐BNIP3 axis and restores mitophagy flux by elevating ATP production in the aging heart.
Ning Jin, Li Zhou, Haixia Gui, Jingjing Tang, Xiaozhen Huang, Wenting Wang, Guorong Jin, Haiqin Cheng, Yuxiang Liang, Xinyi Geng, Zhiwei Peng, Hong Zhao, Zhizhen Liu, Jun Xie   +13 more
wiley   +1 more source

Hepatocyte Growth Hormone Receptor Ablation Is Associated With Aging Phenotypes and Hepatic Mitochondrial Dysfunction

Aging Cell, Volume 25, Issue 10, October 2026.
Hepatocyte‐specific GHR ablation is associated with hepatic and age‐related pathologies, triggering adipose‐liver crosstalk via elevated circulating GH and subsequent CD36‐dependent hepatic steatosis. This loss impairs STAT5b phosphorylation and enhances PPARγ nuclear activation, upregulating Pdk4 and Cd36 to drive mitochondrial dysfunction and ectopic
Kangkang Yang, Yuli Jian, Fusheng Pang, Ming Ying, Qian Yang, Nian Liu, Shujing Wang, Yingjie Wu   +7 more
wiley   +1 more source

Imidacloprid-Induced Ferroptosis-Associated Injury in Common Carp Hepatocytes: Potential Involvement of the miR-153c/SQSTM1 Axis. [PDF]

Toxics
Chen H, Wang Y, Yao Z, Li J, Li P, Diao L.   +5 more
europepmc   +1 more source

Repeated Moderate and Severe Heat Exposure Has Divergent Effects on Skeletal Muscle Mitochondrial, Proteostatic and Neuromuscular Outcomes in Mice

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Repeated heat exposure may promote adaptive remodeling or cumulative tissue burden depending on thermal dose, but its graded molecular and functional consequences during recovery remain unclear. We examined whether repeated moderate (39°C) and severe (41°C) whole‐body hyperthermia produce distinct skeletal muscle trajectories involving ...
Cansu Yakin, Cihan Suleyman Erdogan, Fatma Ozge Tuncel, Yunus Kosif, Bayram Yilmaz   +4 more
wiley   +1 more source

p62/SQSTM1-KEAP1 complex prevents clearance of ubiquitinated Z alpha-1 antitrypsin and aggravates liver proteotoxicity. [PDF]

J Biol Chem
Pastore N, Attanasio S, Annunziata F, D'Agostino C, Maffia V, Colonna R, Giuliano T, Ferriero R, Boffa I, Palmer D, Ng P, De Cegli R, D'Agostino M, Rosenberger F, Strnad P, Chambers JE, Marciniak SJ, Teckman J, Piccolo P, Brunetti-Pierri N.   +19 more
europepmc   +1 more source

Diagnostic utility of inflammatory markers in formalin‐fixed and paraffin‐embedded muscle biopsies for idiopathic inflammatory myopathies

Histopathology, Volume 89, Issue 4, Page 699-709, October 2026.
Formalin‐fixed, paraffin‐embedded (FFPE) muscle tissue supports robust immunohistochemical detection of MHC II, MxA, and p62 with performance comparable to frozen sections. This approach reliably identifies the pathological signatures of inclusion body myositis, dermatomyositis, immune‐mediated necrotizing myopathy, and overlap myositis, enhancing the ...
Chinnawut Suriyonplengsaeng, Jariya Waisayarat   +1 more
wiley   +1 more source

FLCN loss is characterized by SQSTM1/p62 accumulation despite functional autophagy flux in Birt-Hogg-Dubé syndrome-associated kidney cancer. [PDF]

Autophagy Rep
Ullern H, Johannessen JA, Kasikci F, Formica M, Karimi Melve N, Andresen S, Brech A, Axcrona K, Jørgensen K, Farkas L, Enserink JM, Knævelsrud H.   +11 more
europepmc   +1 more source

Synaptic Proteostasis in Health and Disease

Journal of Neurochemistry, Volume 170, Issue 10, October 2026.
The localised creation and degradation of proteins at the pre and postsynaptic terminal are processes that are crucial for neuronal homeostasis. Synaptic proteostasis pathways are frequently reported as dysregulated in neurodevelopmental and neurodegenerative disorders.
Paul G. Donlin‐Asp, Emma L. Clayton
wiley   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy. [PDF]

Adv Sci (Weinh)
Lin Y, Dai M, Dai E, Kang R, Klionsky DJ, Tang D, Sun Y, Lv N, Jiang J.   +8 more
europepmc   +1 more source

TFEB coordinates autophagosome biogenesis and ribophagy during starvation via SQSTM1

(Macro)autophagy is a conserved cellular degradation pathway that delivers substrates to lysosomes via autophagosomes. Among various physiological stimuli, nutrient starvation is the most potent inducer of autophagy.
Frankel, Lisa B., Morrone, Castrese, Settembre, Carmine, Monfregola, Jlenia, Ferrante, Luigi, Polishchuk, Elena, Behrends, Christian, Raimondi, Andrea, Nusco, Edoardo, Iavazzo, Maria, Sacco, Francesca, Carrella, Diego, Levantovsky, Sophie, De Cegli, Rossella, Cinque, Laura   +14 more
core   +1 more source