Results 161 to 170 of about 26,505 (243)

Senescent BMSC‐Derived Thbs1 Drives Inflammaging and Impairs Bone Regeneration by Suppressing PINK1/Parkin‐Mediated Mitophagy in Macrophages

Aging Cell, Volume 25, Issue 6, June 2026.
Aging BMSC‐derived Thbs1 activates the macrophage TGF‐β/Smad3 pathway to transcriptionally repress Pink1, impairing mitophagy and causing mitochondrial ROS accumulation. This redox imbalance drives M1 polarization and IL‐6 secretion. IL‐6 feeds back to BMSCs via the JAK/STAT3 pathway to inhibit osteogenesis and upregulate Thbs1, establishing a self ...
Yifeng Xing, Jingjing Su, Yanjun Lin, Nengwen Huang, Sihui Zhang, Yuwei Zhou, Jie Lu, Weiping Chen, Kaixun He, Wenxiu Yuan, Yang Li, Geyuan Zheng, Pengyuan Hu, Dong Wu, Yanjing Ou, Jiang Chen   +15 more
wiley   +1 more source

FTLD‐TDP‐43 With Motor Neuron Disease Pathology in an Autopsied Patient With Spastic Paraplegia‐30B Harbouring a Homozygous KIF1A Variant

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
KIF1A‐associated neurological disorder (KAND) is a rare hereditary condition caused by KIF1A variants, affecting axonal transport and presenting with a wide clinical spectrum, including hereditary spastic paraplegia. This case of childhood‐onset KAND reveals FTLD‐TDP43 with motor neuron disease pathology emerging late in the disease course, suggesting ...
Rie Saito, Arika Hasegawa, Tetsuya Takahashi, Ryoko Koike, Norikazu Hara, Ramil Gabdulkhaev, Kishin Koh, Akio Kawakami, Yoshihisa Takiyama, Takeshi Ikeuchi, Akiyoshi Kakita   +10 more
wiley   +1 more source

Hypothalamic P62 (SQSTM1) regulates energy balance by modulating leptin signaling

Rationale: The multifaceted functions of p62 (SQSTM1) are increasingly recognized, but its role in hypothalamic metabolism-associated neurons for energy balance has yet to be elucidated. Methods: Single-nucleus RNA sequencing (snRNA-Seq) was performed on
Yang, S, Li, L, Liu, D, Tian, M, Yang, M, Li, Y, Deng, W, Chen, C, Zhu, Z, Zheng, H, Yang, G   +10 more
core   +1 more source

Heterologous expression of SQSTM1/p62 for NMR-spectroscopy and redox-characterization

, 2010
Das humane Protein SQSTM1/p62 ist ein Gerüstprotein, das mit verschiedenen strukturellen Motiven unterschiedliche Substrate binden kann und somit eine wichtige Rolle in mehreren Stoffwechselwegen des menschlichen Körpers spielt.
Hollerer, Ina
core   +1 more source

Tumor stage-dependent expression of autophagy proteins in adrenocortical carcinoma. [PDF]

Front Endocrinol (Lausanne)
Oliveira SB, Sousa D, Costa M, Rios E, Nunes da Silva T, Leite V, Pereira SS, Pignatelli D.   +7 more
europepmc   +1 more source

SQSTM1 mutations and Paget's disease of bone [PDF]

, 2010
Mutations affecting the p62 signalling adapter protein are commonly found in patients with the skeletal disorder Paget‟s disease of bone (PDB). We have extended previous in vitro functional analyses of PDB-mutant p62 proteins (Cavey et al., 2006) to study the effects of several uncharacterised PDB-associated mutations on the ubiquitin-binding ...
openaire   +1 more source

Quantitative analysis of autophagic flux reveals radiation-induced activation of SQSTM1-mediated degradation of protein aggregates and ER-phagy. [PDF]

J Radiat Res
Moriwaki T, Masuda T.
europepmc   +1 more source

Identification and verification of biomarkers associated with integrated stress response in heart failure. [PDF]

Sci Rep
Wu Y, Zhou Y, Huang Q, Sun L, Zhu L, He T, Meng X.   +6 more
europepmc   +1 more source

AMPK-mediated autophagy induction by bisdemethoxycurcumin attenuates senescence and amyloid pathology in 3xTg-AD mice. [PDF]

Autophagy Rep
Khajuria P, Kour D, Sharma K, Singh L, Banoo R, Manhas D, Ramajayan P, Nandi U, B Bharate S, Ahmed Z, Kumar A.   +10 more
europepmc   +1 more source

Autophagy-Lysosomal Axis Stimulation by Beta-Hydroxybutyrate in Astrocytes. [PDF]

Mol Neurobiol
Coronado-Monroy P, Montiel T, García-Velázquez L, Zahar-Pérez M, Massieu L.   +4 more
europepmc   +1 more source