Results 141 to 150 of about 26,505 (243)
Journal of Pineal Research, Volume 78, Issue 4, July 2026.ABSTRACT Oncogenic condensates act as biophysical sanctuaries that stabilize malignant survival programs. However, a universal regulator capable of orchestrating the integrated biophysical axes governing cellular phase behavior has remained elusive.
Doris Loh +3 more
wiley +1 more source
Role of SQSTM1/p62 in regulating Mallory-Denk body in alcohol-associated liver disease
eGastroenterologyBackground Alcohol-associated liver disease (ALD) is a global health problem without an effective treatment. Mallory-Denk body (MDB) is a protein aggregate commonly found in alcohol-associated hepatitis (AH). MDB primarily contains ubiquitinated proteins,
Zhaoli Sun +5 more
doaj +1 more source
Advanced Science, Volume 13, Issue 33, 15 June 2026.An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang +8 more
wiley +1 more source
Drug repositioning identifies potential autophagy inhibitors for the LIR motif p62/SQSTM1 protein
MA.M. is supported by international (project on drug repositioning for LC3-interacting region of autophagy protein p62/SQSTM1 in breast cancer) and national (No.
Cordani, Marco +4 more
core +1 more source
Advanced Science, Volume 13, Issue 33, 15 June 2026.This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang +9 more
wiley +1 more source
Programmed Cell Death in Chronic Rhinosinusitis
Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.ABSTRACT Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological ...
Xingchen Liu +5 more
wiley +1 more source
Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.Tumour‐intrinsic DRAM1, induced by DNA damage and IFN‐γ, activates an autophagy/JAK‐STAT axis that recruits Tregs, causing CD8+ T cell exhaustion and establishing a self‐sustaining, immunotherapy‐resistant “cold” tumour microenvironment. Abstract Background DNA damage‐regulated autophagy modulator 1 (DRAM1) is a lysosomal protein involved in autophagy ...
Jinchun Wu +7 more
wiley +1 more source
, 2019 SQSTM1/p62 (sequestosome 1) is a critical macroautophagy/autophagy receptor that promotes the formation and degradation of ubiquitinated aggregates.
Qianwen Hu (6881138) +6 more
core +1 more source
Food and Medicine Homologous Plants in Osteoporosis: A Scoping Review of Preclinical Evidence
Food Science &Nutrition, Volume 14, Issue 6, June 2026.Food and medicine homologous (FMH) plants and their bioactive compounds exhibit potential osteoprotective effects through multiple complementary mechanisms, including estrogen‐like signaling, attenuation of oxidative stress, modulation of the gut microbiota–bone axis, and regulation of autophagy.
Long Zhao +4 more
wiley +1 more source