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Emerging Drugs, 1997
Hypercholesterolaemia (defined as elevated levels [> 200 mg/dl] of plasma total cholesterol [TC]) is a significant risk factor for the development of atherosclerosis. The discovery and development of new hypocholesterolaemic agents has been a high priority for both pharmaceutical and academic researchers because of the devastating nature of the illness
DR Sliskovic, JA Picard
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Hypercholesterolaemia (defined as elevated levels [> 200 mg/dl] of plasma total cholesterol [TC]) is a significant risk factor for the development of atherosclerosis. The discovery and development of new hypocholesterolaemic agents has been a high priority for both pharmaceutical and academic researchers because of the devastating nature of the illness
DR Sliskovic, JA Picard
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1969
It has been observed that the proton, which is located at C-14 in squalene or C-13 in the "presterol cation," migrates less than 10% of the time (with a confidence level of 74%) to C-20 in lanosterol, and therefore 90% of the time (with a confidence level of 74%) to C-17 in lanosterol. If enzymatically controlled reactions are stereospecific, then at C-
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It has been observed that the proton, which is located at C-14 in squalene or C-13 in the "presterol cation," migrates less than 10% of the time (with a confidence level of 74%) to C-20 in lanosterol, and therefore 90% of the time (with a confidence level of 74%) to C-17 in lanosterol. If enzymatically controlled reactions are stereospecific, then at C-
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Chemical & Engineering News Archive, 1997
Chemists at the University of Utah, Salt Lake City, have trapped a cationic intermediate in the biosynthesis of squalene, a key precursor of cholesterol. Their insights into the remarkable enzymatic reaction may offer important leads to the design of drugs that reduce cholesterol levels by blocking squalene biosynthesis.
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Chemists at the University of Utah, Salt Lake City, have trapped a cationic intermediate in the biosynthesis of squalene, a key precursor of cholesterol. Their insights into the remarkable enzymatic reaction may offer important leads to the design of drugs that reduce cholesterol levels by blocking squalene biosynthesis.
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1985
Publisher Summary This chapter describes methods pertinent to the assay of the reactions in squalene synthesis. The enzyme may be solubilized and depleted of membrane lipids, with loss of catalytic activities. When reconstituted with the appropriate lipids, normal catalytic behavior can be restored.
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Publisher Summary This chapter describes methods pertinent to the assay of the reactions in squalene synthesis. The enzyme may be solubilized and depleted of membrane lipids, with loss of catalytic activities. When reconstituted with the appropriate lipids, normal catalytic behavior can be restored.
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