Results 51 to 60 of about 42,005 (248)

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Sustainable biosynthesis of squalene from waste cooking oil by the yeast Yarrowia lipolytica

Metabolic Engineering Communications
Squalene is a highly sought-after triterpene compound in growing demand, and its production offers a promising avenue for circular economy practices.
Shuhui Wang, Xu Sun, Yuqing Han, Zhuo Li, Xiaocong Lu, Hongrui Shi, Cui-ying Zhang, Adison Wong, Aiqun Yu   +8 more
doaj   +1 more source

In Situ Lipoprotein‐seeking Dye for in Vivo Real‐Time Imaging of Lipid Dysregulation Diseases

Advanced Science, EarlyView.
This study develops lipoprotein‐seeking NIR‐II dyes that specifically bind circulating lipoproteins. These dyes form ultra‐stable complexes with endogenous lipoprotein, enabling real‐time, high‐contrast imaging of fatty liver and atherosclerotic plaques. Tunable binding kinetics allow customized imaging windows.
Yijing Du, Zetao Dang, Baofeng Xu, Jiajun Xu, Dan Wang, Yuewei Zhang, Shoujun Zhu   +6 more
wiley   +1 more source

The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-ß [PDF]

, 2017
Cholesterol is required for the formation and function of some signalling platforms. In synaptosomes, amyloid-β (Aβ) oligomers, the causative agent in Alzheimer's disease, bind to cellular prion proteins (PrPC) resulting in increased cholesterol ...
Anderson, Bate, Bate, Bate, Baxter, Bryleva, Chan, Chang, Chen, Chen, Chiarini, Chiesa, Dunkley, Gaudreault, Gilch, Giuffrida, Gocze, Gylys, Hammond, Herms, Hosie, Kaneko, Kawarabayashi, Koch, Laurén, Linden, Linetti, Lingwood, Lingwood, London, Maglio, Maxfield, Mc Donald, McLean, Montine, Moskowitz, Mouillet-Richard, Nalefski, Naslavsky, Osborne, Pani, Puglielli, Rajendran, Robinet, Ryan, Schroeder, Selkoe, Shankar, Sharma, Simons, Solforosi, Stahl, Sugiyama, Suzuki, Taraboulos, Walsh, Williamson, Yang   +57 more
core   +2 more sources

Schwann Cell Synthesized Cholesterol Orchestrates Peripheral Nerve Regeneration via Structural and IGF1‐Dependent Signaling Mechanisms

Advanced Science, EarlyView.
This study reveals that Schwann cell FDFT1‐mediated cholesterol synthesis is essential for peripheral nerve regeneration via dual roles: as a structural component for myelin and as a metabolic signal that upregulates IGF1. IGF1 promotes axonal growth through paracrine action and enhances Schwann cell differentiation/ myelination via an intrinsic IGF1R ...
Shuyi Xu, Ye He, Ying Zou, Mengyao Zhao, Jiaqi Zhang, Yizhou Xu, Jiale Cai, Xiongbo Luo, Xinrui Ma, Saini Wu, Yuling Huang, Xianghai Wang, Jiasong Guo   +12 more
wiley   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches. [PDF]

Med Res Rev
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Mavridi D, Katavati T, Kourounakis AP.
europepmc   +2 more sources

Paleoproterozic Icehouses and the Evolution of Oxygen Mediating Enzymes: The Case for a Late Origin of Photosystem -- II [PDF]

, 2008
Two major geological problems regarding the origin of oxygenic photosynthesis are: (1) identifying a source of oxygen predating biological oxygen production and capable of driving the evolution of oxygen tolerance, and (2) determining when oxygenic ...
Kirschvink, Joseph L., Kopp, Robert E.
core  

Transition from confined to bulk dynamics in symmetric star-linear polymer mixtures

, 2019
We report on the linear viscoelastic properties of mixtures comprising multiarm star (as model soft colloids) and long linear chain homopolymers in a good solvent.
Deepak, Vishnu D., Gauthier, Mario, Parisi, Daniele, Truzzolillo, Domenico, Vlassopoulos, Dimitris   +4 more
core   +3 more sources

From Sharks to Yeasts: Squalene in the Development of Vaccine Adjuvants

Pharmaceuticals, 2022
Squalene is a natural linear triterpene that can be found in high amounts in certain fish liver oils, especially from deep-sea sharks, and to a lesser extent in a wide variety of vegeTable oils. It is currently used for numerous vaccine and drug delivery
Adélia Mendes, João Azevedo-Silva, João C. Fernandes   +2 more
doaj   +1 more source

A New Era for Using Natural Pigments: The Case of the C50 Carotenoid Called Bacterioruberin

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Haloarchaea are extremophilic microorganisms belonging to the Archaea domain that require high salt concentrations to live, thus inhabiting ecosystems like salty ponds, salty marshes, or extremely salty lagoons. They are more abundant and widely distributed worldwide than initially expected.
Micaela Giani, Elena Valdés, José María Miralles‐Robledillo, Guillermo Martínez, Carmen Pire, Rosa María Martínez‐Espinosa   +5 more
wiley   +1 more source