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Synthesis and Structural Analysis of New (−)-Cytisine Squaramides [PDF]
MoleculesDerivatives of squaric acid are valuable building blocks with promising applications in the investigation of various bioactivities. In this study, we focus on squaramides functionalized with the (−)-cytisine moiety, an alkaloid known for its bioactivity ...
Anna K. Przybył +2 more
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Squaramide-functionalised amino acids and their application in solid-phase peptide synthesis [PDF]
RSC AdvancesSquaramides are well-known charge-neutral bioisosteres of many nitrogenous functional groups, including those found in the side chains of amino acids (e.g., Arg, Asn, Glu, and Lys).
Kylie A. Agnew-Francis +2 more
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Lysosome-Targeted Squaramide Anion Transporters. [PDF]
ChemistryABSTRACT Targeting anion transporters to specific organelles has previously been shown to be an effective strategy to enhance their cytotoxicities against cancerous cell lines. In this work a new family of squaramide anion transporters appended with two different lysosome targeting groups via a 1,4‐substituted ...
Feo E +5 more
europepmc +3 more sources
Squaramide-Naphthalimide Conjugates – Exploiting Self-Aggregation Effects in Acetate Recognition
Results in Chemistry, 2022 The synthesis of three squaramide-containing bis-naphthalimide conjugates (1–3) are reported where the structures differ by the length of the carbon chain between the squaramide core and the 1,8-naphthalimide fluorophores.
Robert B.P. Elmes
exaly +3 more sources
Functionalized Cytisine Squaramides: Synthesis, Structural Elucidation, and Co-Crystallization [PDF]
MoleculesSynthesis of bifunctional cytisine–squaramide derivatives bearing a single amino acid moiety has revealed an unexpected and intriguing chemical challenge. During modification of cytisine squaramates with α-amino acids, base-sensitive amido esters readily
Anna K. Przybył +3 more
doaj +2 more sources
Temperature-controlled conformational switching of squaramides enabled by side-chain hydrogen bonding [PDF]
RSC AdvancesPrecise control of local conformational bias is essential for constructing stimulus-responsive aromatic architectures. Amide-derived scaffolds such as squaramides are particularly attractive targets, as their moderate rotational barriers allow ...
Kazusa Kuyama +11 more
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Investigation of Chloride Binding Abilities of Symmetric Squaramides. [PDF]
ACS OmegaIn this work, three symmetric squaramide derivatives were synthesized, and their anion-binding properties were systematically investigated. The binding properties of squaramides I-III with anions were determined by spectroscopic titration in DMSO-d 6 using tetrabutyl ammonium salts.
Mert S, Özger SM, Vardar A, Erdebil Ö.
europepmc +5 more sources
Molecules, 2016 The organocatalysis-based dynamic kinetic resolution (DKR) process has proved to be a powerful strategy for the construction of chiral compounds. In this feature review, we summarized recent progress on the DKR process, which was promoted by chiral ...
Xumu Zhang, Xinquan Hu, Xiuqin Dong
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Squaramide Based Organocatalysts in Organic Transformations
Current Organic Chemistry, 2016 Organocatalysis is an emerging and new field towards the direction of asymmetric synthesis and has shown a tremendous growth in 21st century. As the demand for chiral pharmaceuticals and chiral organic molecules is increasing immensely, different types of organocatalysts have been developed and used from time ...
Abdul Rouf, Cihangir Tanyeli
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From Binding to Building: A Squaramide-Based Ion Pair Receptor as an Iniferter for Functional Polymer Synthesis [PDF]
MoleculesTo address the challenge of developing the first squaramide-based ion pair receptor acting as an iniferter in the polymerization process, a well-known BDPA molecule with specific radical functions was incorporated into its structure.
Mikołaj Prokopski +4 more
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