Head vs. Tail Squaramide–Naphthalimide Conjugates: Self-Assembly and Anion Binding Behaviour [PDF]
Chemistry, 2022 The syntheses of two squaramide–naphthalimide conjugates (SN1 and SN2) are reported; the structures of SN1 and SN2 differ by the attachment of a squaramide—either at the ‘head’ or the ‘tail’ of the naphthalimide fluorophore. Both compounds displayed weak
Anthony A. Abogunrin +3 more
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Accessing acyclic vicinal tetrasubstituted stereocenters via biomimetic Cu/squaramide cooperative catalysed asymmetric Mannich reactions [PDF]
Nature CommunicationsThe catalytic asymmetric Mannich reaction offers efficient approaches for the simultaneous construction of a C–C bond and two adjacent stereocenters in a single step.
Wen-Run Zhu +10 more
doaj +2 more sources
Investigation of a squaramide motif as a bioisostere of the amino-acid group of S-adenosyl-L-methionine and its functional impact on RNA methylation [PDF]
Communications ChemistryMethyltransferases (MTases) are enzymes that methylate biomolecules like proteins, DNA, RNA, lipids, and small molecules, mostly using S-adenosyl-L-methionine (SAM) as a methyl donor.
Jianxun Du +10 more
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Heterocyclic-Fused Squaramides: Anionophores With Antimicrobial Activity. [PDF]
ChembiochemAntimicrobial resistance is regarded as one of the foremost public health risks of the 21st century, highlighting the need for new antimicrobial agents and chemical tools to interrogate their biological activity. Artificial transmembrane anion transporters have emerged as promising supramolecular scaffolds in this context, having demonstrated membrane ...
Brennan LE +3 more
europepmc +4 more sources
Effect of urea and squaramide IMPDH inhibitors on C. parvum: in vitro trial design impacts the assessment of drug efficacy [PDF]
International Journal for Parasitology: Drugs and Drug ResistanceThe protozoan parasite Cryptosporidium is the etiological agent of cryptosporidiosis, a ubiquitous diarrheic disease affecting humans and animals. Treatment options are limited, highlighting an urgent need for novel therapeutics.
Anne-Charlotte Lenière +3 more
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Review of the history and application of squaramide in organocatalysis
Revista Científica, 2018 Squaramide and its derivatives represent an important group of substances that are currently being successfully applied in asymmetric organocatalitic strategies, which is why this contribution presents a summary of the state of the art related to the ...
Eduardo Hipólito Hernández +5 more
doaj +2 more sources
A tale of two inhibitors: diarylquinolines and squaramides
The EMBO Journal, 2023 The diarylquinoline bedaquiline (BDQ) is an FDA-approved drug for the treatment of multidrug-resistant tuberculosis that targets the mycobacterial adenosine triphosphate (ATP) synthase, a key enzyme in cellular respiration. In a recent study, Courbon et al (2023) examine the interaction between Mycobacterium smegmatis ATP synthase with the second ...
James Chen, Damian C Ekiert
openaire +2 more sources
, 2020 A highly stereoselective Mannich reaction of α-amino acid derived azlactones with isatin-derived ketimines enabled by a chiral bifunctional squaramide organocatalyst is reported, affording α,β-diamino acid derivatives bearing vicinal quaternary ...
Jianfeng Xu (80211) +4 more
core +2 more sources
Asymmetric organocatalytic Michael addition of cyclopentane-1,2-dione to alkylidene oxindole
Beilstein Journal of Organic Chemistry, 2022 An asymmetric Michael reaction between cyclopentane-1,2-dione and alkylidene oxindole was studied in the presence of a multifunctional squaramide catalyst. Michael adducts were obtained in high enantioselectivities and in moderate diastereoselectivities.
Estelle Silm +2 more
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Tripodal, Squaramide-Based Ion Pair Receptor for Effective Extraction of Sulfate Salt
Molecules, 2021 Combining three features—the high affinity of squaramides toward anions, cooperation in ion pair binding and preorganization of the binding domains in the tripodal platform—led to the effective receptor 2.
Damian Jagleniec +2 more
doaj +1 more source