C323 of SR-BI is required for SR-BI-mediated HDL binding and cholesteryl ester uptake[S] [PDF]
Journal of Lipid Research, 2011 Scavenger receptor BI (SR-BI) is an HDL receptor. It binds HDL and mediates the uptake of cholesteryl ester from HDL. Early studies have pointed out that the extracellular domain of SR-BI is critical for SR-BI-mediated cholesteryl ester uptake.
Ling Guo +4 more
doaj +5 more sources
Challenges in using cultured primary rodent hepatocytes or cell lines to study hepatic HDL receptor SR-BI regulation by its cytoplasmic adaptor PDZK1. [PDF]
PLoS ONE, 2013 PDZK1 is a four PDZ-domain containing cytoplasmic protein that binds to a variety of membrane proteins via their C-termini and can influence the abundance, localization and/or function of its target proteins.
Kosuke Tsukamoto +5 more
doaj +20 more sources
The potential role of scavenger receptor B type I (SR‐BI) in SARS‐CoV‐2 infection [PDF]
Immunity, Inflammation and Disease, 2023 Scavenger receptor type B I (SR‐BI), the major receptor for high‐density lipoprotein (HDL) mediates the delivery of cholesterol ester and cholesterol from HDL to the cell membrane.
Luay Alkazmi +6 more
doaj +2 more sources
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport. [PDF]
Biochemistry, 2014 High-density lipoproteins (HDLs) are athero-protective, primarily because of their ability to promote cholesterol flux from peripheral tissues to the liver by reverse cholesterol transport (RCT). The delivery of HDL-cholesteryl esters (CE) into cells is mediated by the HDL receptor, scavenger receptor class B type I (SR-BI), a promising target for ...
Kartz GA +3 more
europepmc +4 more sources
Alternative forms of the scavenger receptor BI (SR-BI)
Journal of Lipid Research, 1997 The class B, type I scavenger receptor has been implicated as a receptor for high density lipoprotein (HDL). We have isolated a murine cDNA clone encoding an alternative form of SR-BI that differs in the putative cytoplasmic domain of the receptor.
N R Webb +4 more
doaj +3 more sources
Targeting SR-BI for Cancer Diagnostics, Imaging and Therapy. [PDF]
Front Pharmacol, 2016 Scavenger receptor class B type I (SR-BI) plays an important role in trafficking cholesteryl esters between the core of high density lipoprotein and the liver. Interestingly, this integral membrane protein receptor is also implicated in the metabolism of cholesterol by cancer cells, whereby overexpression of SR-BI has been observed in a number of ...
Rajora MA, Zheng G.
europepmc +5 more sources
Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma [PDF]
BMC Cancer, 2018 Background Scavenger receptor class B type I (SR-BI) has been reported to be involved in carcinogenesis of several human cancers. However, it is currently unknown whether SR-BI plays a role in clear cell renal cell carcinoma (ccRCC).
Guang-hua Xu +16 more
doaj +2 more sources
SR-BI Interactome Analysis Reveals a Proviral Role for UGGT1 in Hepatitis C Virus Entry [PDF]
Frontiers in Microbiology, 2019 Hepatitis C virus (HCV) entry is mediated by multiple co-receptors including scavenger receptor class B, type I (SR-BI). To elucidate the interactome of human SR-BI, we performed immunoprecipitation (IP) experiment coupled with mass spectrometry (MS ...
Jiazhao Huang +7 more
doaj +2 more sources
SR-BI-directed HDL-cholesteryl ester hydrolysis
Journal of Lipid Research, 2003 We have examined the metabolic fate of HDL cholesteryl ester (CE) delivered to cells expressing scavenger receptor class B type I (SR-BI). Comparison of SR-BI with a related class B scavenger receptor, CD36, showed a greater uptake and a more rapid and ...
Margery A. Connelly +3 more
doaj +3 more sources
Deficient Vitamin E Uptake During Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI [PDF]
Scientific Reports, 2017 SR-BI is the main receptor for high density lipoproteins (HDL) and mediates the bidirectional transport of lipids, such as cholesterol and vitamin E, between these particles and cells. During early development, SR-BI is expressed in extraembryonic tissue,
Nicolás Santander +9 more
doaj +2 more sources