Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma [PDF]
BMC Cancer, 2018 Background Scavenger receptor class B type I (SR-BI) has been reported to be involved in carcinogenesis of several human cancers. However, it is currently unknown whether SR-BI plays a role in clear cell renal cell carcinoma (ccRCC).
Guang-hua Xu +16 more
doaj +3 more sources
Targeting SR-BI for Cancer Diagnostics, Imaging and Therapy. [PDF]
Front Pharmacol, 2016 Scavenger receptor class B type I (SR-BI) plays an important role in trafficking cholesteryl esters between the core of high density lipoprotein and the liver. Interestingly, this integral membrane protein receptor is also implicated in the metabolism of
Rajora MA, Zheng G.
europepmc +7 more sources
Deficient Vitamin E Uptake During Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI [PDF]
Scientific Reports, 2017 SR-BI is the main receptor for high density lipoproteins (HDL) and mediates the bidirectional transport of lipids, such as cholesterol and vitamin E, between these particles and cells. During early development, SR-BI is expressed in extraembryonic tissue,
Nicolás Santander +9 more
doaj +3 more sources
SR-BI: Linking Cholesterol and Lipoprotein Metabolism with Breast and Prostate Cancer. [PDF]
Front Pharmacol, 2016 Studies have demonstrated the significant role of cholesterol and lipoprotein metabolism in the progression of cancer. The SCARB1 gene encodes the scavenger receptor class B type I (SR-BI), which is an 82-kDa glycoprotein with two transmembrane domains ...
Gutierrez-Pajares JL +3 more
europepmc +9 more sources
Macrophage SR-BI modulates autophagy via VPS34 complex and PPARα transcription of Tfeb in atherosclerosis. [PDF]
J Clin Invest, 2021 Autophagy modulates lipid turnover, cell survival, inflammation and atherogenesis. Scavenger receptor class B type I (SR-BI) plays a crucial role in lysosome function. Here, we demonstrate that SR-BI regulates autophagy in atherosclerosis. SR-BI deletion
Tao H +8 more
europepmc +2 more sources
High-Density Lipoprotein Therapy in Stroke: Evaluation of Endothelial SR-BI-Dependent Neuroprotective Effects. [PDF]
Int J Mol Sci, 2020 High-density lipoproteins (HDLs) display endothelial protective effects. We tested the role of SR-BI, an HDL receptor expressed by endothelial cells, in the neuroprotective effects of HDLs using an experimental model of acute ischemic stroke.
Tran-Dinh A +10 more
europepmc +2 more sources
The potential role of scavenger receptor B type I (SR‐BI) in SARS‐CoV‐2 infection [PDF]
Immunity, Inflammation and Disease, 2023 Scavenger receptor type B I (SR‐BI), the major receptor for high‐density lipoprotein (HDL) mediates the delivery of cholesterol ester and cholesterol from HDL to the cell membrane.
Luay Alkazmi +6 more
doaj +2 more sources
Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR. [PDF]
Int J Mol Med, 2019 The farnesoid X receptor (FXR) is known to regulate the gene expression of SR-BI, which mediates plasma high-density lipoprotein (HDL)-cholesterol uptake. Our previous study demonstrated that the activation of FXR by obeticholic acid (OCA) lowered plasma
Dong B +4 more
europepmc +2 more sources
SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1. [PDF]
Front Physiol, 2017 The vascular endothelium supplying the brain exhibits very low paracellular and transcellular permeability and is a major constituent of the blood-brain barrier.
Fung KY +5 more
europepmc +2 more sources
Loss of SR-BI Down-Regulates MITF and Suppresses Extracellular Vesicle Release in Human Melanoma. [PDF]
Int J Mol Sci, 2019 Melanoma is a skin tumor with a high tendency for metastasis and thus is one of the deadliest cancers worldwide. Here, we investigated the expression of the scavenger receptor class B type 1 (SR-BI), a high-density lipoprotein (HDL) receptor, and tested ...
Kinslechner K +11 more
europepmc +2 more sources