Results 251 to 260 of about 895,142 (270)
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Blood, 2010
Dysregulated cholesterol transport and metabolism are important risk factors for atherothrombosis and are commonly associated with enhanced platelet reactivity; however, the molecular mechanisms linking hypercholesterolemia with increased platelet function remain unclear.
Zane S, Kaplan, Shaun P, Jackson
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Dysregulated cholesterol transport and metabolism are important risk factors for atherothrombosis and are commonly associated with enhanced platelet reactivity; however, the molecular mechanisms linking hypercholesterolemia with increased platelet function remain unclear.
Zane S, Kaplan, Shaun P, Jackson
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Influence of the HDL receptor SR-BI on atherosclerosis
Current Opinion in Lipidology, 1999The scavenger receptor class B, type I (SR-BI) is an HDL receptor that mediates selective cholesterol uptake from HDL to cells. In rodents, SR-BI has a critical influence on plasma HDL-cholesterol concentration and structure, the delivery of cholesterol to steroidogenic tissues, female fertility, and biliary cholesterol concentration.
M, Krieger, K, Kozarsky
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SR‐BI and HDL Cholesteryl Ester Metabolism
Endocrine Research, 2004Scavenger receptor class B, type I (SR-BI) is the receptor for high density lipoprotein (HDL) that mediates cellular uptake of HDL cholesteryl ester (CE) and is a major route for cholesterol delivery to steroidogenic pathways. SR-BI is localized in specialized microvillar channel plasma membrane compartments that retain HDL and are sites for HDL CE ...
Margery A, Connelly, David L, Williams
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SR-BI and cholesterol uptake into steroidogenic cells
Trends in Endocrinology & Metabolism, 2003Scavenger receptor class B, type I (SR-BI) is a receptor for high-density lipoprotein (HDL) that mediates cellular uptake of HDL cholesteryl ester (HDL CE) and is the major route for cholesterol delivery to the steroidogenic pathway. SR-BI is localized in specialized microvillar channels in the plasma membrane that retain HDL and are sites of selective
Margery A, Connelly, David L, Williams
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The Janus-faced role of SR-BI in atherosclerosis
Nature Metabolism, 2019The entry of remnants of cholesterol-rich lipoproteins, such as low-density lipoprotein (LDL), from the blood stream into the intima of large arteries initiates and then perpetuates atherosclerosis. A study published in Nature sheds new light on this important process by identifying scavenger receptor BI (SR-BI) as a major receptor that mediates LDL ...
Xinbo Zhang, Carlos Fernández-Hernando
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2010
Scavenger receptor class B type I (SR-BI) was the first molecularly well-defined and functionally active cell surface HDL receptor to be described. SR-BI mediates the transfer of cholesterol from HDL to cells via a mechanism called selective lipid uptake. In vitro and in vivo studies have established that SR-BI is a physiologically relevant lipoprotein
Attilio Rigotti, Monty Krieger
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Scavenger receptor class B type I (SR-BI) was the first molecularly well-defined and functionally active cell surface HDL receptor to be described. SR-BI mediates the transfer of cholesterol from HDL to cells via a mechanism called selective lipid uptake. In vitro and in vivo studies have established that SR-BI is a physiologically relevant lipoprotein
Attilio Rigotti, Monty Krieger
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Regulation of Adipocyte Metabolic Homeostasis by SR‐BI and PCPE2
The FASEB Journal, 2022Obesity continues to be an epidemic in the United States, placing individuals at a higher risk of developing other comorbidities such as type 2 diabetes and cardiovascular disease. Adipocytes accumulate excess triglycerides and undergo hypertrophic expansion as a protective mechanism to avoid lipotoxicity.
Darcy A. Knaack +4 more
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SR-BI et métabolisme du cholestérol.
médecine/sciences, 1999Dans la classe des recepteurs « eboueurs » (scavenger), le SR-BI (scavenger receptor class B type 1) murin, dont l'homologue humain est CLA1 (CD36 and LIMPII analogous-1), possede la fonction inattendue de lier les HDL, facilitant l'entree selective du cholesterol esterifie des HDL dans la cellule.
M Combettes-Souverain +4 more
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Biochemistry, 2005
Apolipoprotein E (apoE) and the lipoprotein receptor SR-BI play critical roles in lipid and lipoprotein metabolism. We have examined the cholesterol efflux from wild-type (WT) and mutant forms of SR-BI expressed in ldlA-7 cells using reconstituted discoidal particles consisting of apoE, 1-palmitoyl-2-oleoyl-l-phospatidylcholine (POPC), and cholesterol (
Angeliki, Chroni +4 more
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Apolipoprotein E (apoE) and the lipoprotein receptor SR-BI play critical roles in lipid and lipoprotein metabolism. We have examined the cholesterol efflux from wild-type (WT) and mutant forms of SR-BI expressed in ldlA-7 cells using reconstituted discoidal particles consisting of apoE, 1-palmitoyl-2-oleoyl-l-phospatidylcholine (POPC), and cholesterol (
Angeliki, Chroni +4 more
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Role of SR-BI in regulating lipoprotein structure and metabolism
Drug News & Perspectives, 2001The scavenger receptor class B type I (SR-BI) is a cell surface lipoprotein receptor that mediates physiologically relevant selective cholesteryl ester uptake from high-density lipoprotein (HDL). SR-BI appears to be required for the maintenance of reverse cholesterol transport, normal HDL levels and HDL structure by means of hepatic-selective HDL ...
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