Results 101 to 110 of about 111,466 (171)

Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

Nature Communications, 2017
Src-family kinases Fyn and Lyn are signaling components downstream of ITAM-bearing antigen receptors. Here the authors show that by phosphorylating SHP-1 at different residues, Lyn and Fyn can have opposing regulatory effects on ITAM receptors.
Sanae Ben Mkaddem, Amaya Murua, Héloise Flament, Dimitri Titeca-Beauport, Carine Bounaix, Luca Danelli, Pierre Launay, Marc Benhamou, Ulrich Blank, Eric Daugas, Nicolas Charles, Renato C. Monteiro   +11 more
doaj   +1 more source

Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. [PDF]

, 2003
Antagonists of alphavbeta3 and alphavbeta5 disrupt angiogenesis in response to bFGF and VEGF, respectively. Here, we show that these alphav integrins differentially contribute to sustained Ras-extracellular signal-related kinase (Ras-ERK) signaling in ...
Cheresh, David A, Frausto, Ricardo, Hood, John D, Kiosses, William B, Schwartz, Martin A   +4 more
core   +1 more source

Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models. [PDF]

J Exp Med, 2023
Futosi K, Németh T, Horváth ÁI, Abram CL, Tusnády S, Lowell CA, Helyes Z, Mócsai A.   +7 more
europepmc   +1 more source

ArtinM Cytotoxicity in B Cells Derived from Non-Hodgkin's Lymphoma Depends on Syk and Src Family Kinases. [PDF]

Int J Mol Sci, 2023
Barboza BR, Thomaz SMO, Junior AC, Espreafico EM, Miyamoto JG, Tashima AK, Camacho MF, Zelanis A, Roque-Barreira MC, da Silva TA.   +9 more
europepmc   +1 more source

c-Kit Receptor Maintains Sensory Axon Innervation of the Skin through Src Family Kinases. [PDF]

J Neurosci, 2022
Tuttle AM, Pomaville MB, Delgado KC, Wright KM, Nechiporuk AV.   +4 more
europepmc   +1 more source

Wnt5a induces ROR1 to recruit cortactin to promote breast-cancer migration and metastasis. [PDF]

, 2019
ROR1 is a conserved oncoembryonic surface protein expressed in breast cancer. Here we report that ROR1 associates with cortactin in primary breast-cancer cells or in MCF7 transfected to express ROR1.
Briggs, Steven P, Hasan, Md Kamrul, Kipps, Thomas J, Lam, Sharon M, Parker, Barbara A, Shen, Zhouxin, Widhopf, George F, Zhang, Suping   +7 more
core   +1 more source

Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy. [PDF]

Mol Cancer Ther, 2022
Sinnett-Smith J, Anwar T, Reed EF, Teper Y, Eibl G, Rozengurt E.   +5 more
europepmc   +1 more source

Identification of Src Family Kinases as Potential Therapeutic Targets for Chemotherapy-Resistant Triple Negative Breast Cancer. [PDF]

Cancers (Basel), 2022
Kohale IN, Yu J, Zhuang Y, Fan X, Reddy RJ, Sinnwell J, Kalari KR, Boughey JC, Carter JM, Goetz MP, Wang L, White FM.   +11 more
europepmc   +1 more source

Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer. [PDF]

Cancers (Basel), 2022
Kakarla M, ChallaSivaKanaka S, Dufficy MF, Gil V, Filipovich Y, Vickman R, Crawford SE, Hayward SW, Franco OE.   +8 more
europepmc   +1 more source

Src family kinases inhibit differentiation of intestinal epithelial cells through the Hippo effector YAP1. [PDF]

Biol Open, 2021
Fallah S, Beaulieu JF.
europepmc   +1 more source