Results 121 to 130 of about 512,141 (378)

Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility. [PDF]

, 2011
BackgroundCell migration plays an important role in many physiological and pathological processes, including immune cell chemotaxis and cancer metastasis.
Liao, Kan, Liu, Yang, Wang, Wenqi
core   +2 more sources

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Preparedness of non-hospital health centers to manage patients with life-threatening emergency conditions: findings from a qualitative study

BMC Health Services Research, 2020
Background Management of Life-threatening Emergency (LTE) patients in urban and rural areas is an important challenge, which can affect pre-hospital mortality rate.
Homayoun Sadeghi-Bazargani, Mehrdad Amir-Behghadami, Masoumeh Gholizadeh, Ali Janati, Farzad Rahmani   +4 more
doaj   +1 more source

Multi-task Image Classification via Collaborative, Hierarchical Spike-and-Slab Priors

, 2015
Promising results have been achieved in image classification problems by exploiting the discriminative power of sparse representations for classification (SRC).
Dao, Minh, Monga, Vishal, Mousavi, Hojjat Seyed, Srinivas, Umamahesh, Suo, Yuanming, Tran, Trac. D.   +5 more
core   +1 more source

Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1.

Cancer Research, 2014
Virtually all transcription factors partner with coactivators that recruit chromatin remodeling factors and interact with the basal transcription machinery.
Ying Wang, D. Lonard, Yang Yu, D. Chow, T. Palzkill, Jin Wang, R. Qi, Alexander J. Matzuk, Xianzhou Song, Franck Madoux, P. Hodder, Peter S. Chase, P. Griffin, Suoling Zhou, L. Liao, Jianming Xu, B. O’Malley   +16 more
semanticscholar   +1 more source

Controlled Air Gap Formation between W and TiO2 Films via Sub‐Surface TiO2 Atomic Layer Etching

Advanced Materials Technologies, EarlyView.
Delivering SiH4 and WF6 to a lined array of TiO2 films produces a thin film of tungsten while simultaneously, the underlying TiO2 is removed. When the W‐coated TiO2 structure is exposed to further etching cycles after deposition, TiO2 etching continues vertically and laterally, creating a self‐supported W structure and a vacant air gap.
Hannah R. M. Margavio, Jimmy Nguyen, Man Hou Vong, Nicholas M. Carroll, Ishwar Singh, Noel Arellano, Gregory N. Parsons   +6 more
wiley   +1 more source

Recent Advances in Robotic Systems for Robot‐Assisted Transoral Surgical Procedures: A Systematic Review

Advanced Robotics Research, EarlyView.
This review systematically examines robotic systems for robot‐assisted transoral surgical procedures, classifying them based on transoral access depth, and evaluates their fundamental design principles, mechanical innovations, algorithmic advancements, and clinical implementation status.
Yuhao Shi, Jichen Li, Yuekun Yang, Zheng Li, Toshio Fukuda, Chaoyang Shi   +5 more
wiley   +1 more source

Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Advanced Science, EarlyView.
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang, Yongxiang Liu, Huanling Zhang, Huan Jin, Feifei Xu, Xiaojuan Wang, Chunyuan Xie, Hui Guo, Tiantian Wang, Yanxun Lin, Qi Zhao, Penghui Zhou, Jing Tan, Jin‐Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +19 more
wiley   +1 more source

Variation on an Src-like Theme [PDF]

Cell, 2003
The modularity of protein architecture and the diversity of protein domains hint at a vast combinatorial richness. But evolution appears to have been relatively conservative about selecting new combinations. When a particular grouping of domains within a polypeptide chain can perform a concerted function, that combination tends to reappear in multiple ...
openaire   +3 more sources

Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance

Advanced Science, EarlyView.
This study identifies a novel oncogenic role and a previously unrecognized phosphorylation substrate of BCKDK in RCC, wherein it promotes tumor progression and drug resistance through AKT phosphorylation at both Thr308 and Ser473 sites and activation of AKT/mTOR and AKT/ABCB1 signaling pathways, offering a promising prognostic marker and therapeutic ...
Qin Tian, Jinxiang Wang, Qiji Li, Yangruiyu Liu, Yanping Chen, Jiacheng Feng, Zi‐Ning Lei, Harsh Patel, Chao‐Yun Cai, Yuzhi Xu, Chuntao Quan, Lingyan Fei, Zexiu Xiao, Shuo Fang, Tianxin Lin, Zhe‐Sheng Chen, Yuchen Liu, Leli Zeng, Yihang Pan   +18 more
wiley   +1 more source