Results 181 to 190 of about 150,059 (222)

Kaempferol inhibits osteoclast differentiation and bone resorption by targeting the TNF-α/NF-κB and SRC/PI3K/AKT signaling pathways. [PDF]

Sci Rep
Yu Q, Jiang T, Zhao Y, Liu Z, Guan Z.
europepmc   +1 more source

Systemic Absorption and Pharmacokinetics of Five Novel Topical Dermatologic Agents: A Review

JEADV Clinical Practice, EarlyView.
ABSTRACT In recent years, innovative topical medications with novel mechanisms of action have emerged to treat common dermatologic conditions such as acne, atopic dermatitis, vitiligo, and actinic keratoses. These molecularly targeted therapies offer improved safety and tolerability compared to traditional options like corticosteroids.
Mary Dyson, Kara Hurley, Hannah Chaudhury, Lara Shehadeh, Cameron West   +4 more
wiley   +1 more source

Protein tyrosine kinase Src suppresses hepatitis C virus particle release through regulation of Ndrg1. [PDF]

J Biol Chem
Fu L, Takeuchi K, Chihara K, Feng W, Sada K.   +4 more
europepmc   +1 more source

Carbon Stock and Environmental Variations of Typical Plantations in Mufu Mountain in Hubei Province, China

Land Degradation &Development, EarlyView.
ABSTRACT Forest ecosystems play a critical role in the global carbon cycle. As a significant terrestrial carbon sink, plantations exhibit carbon stock patterns that are shaped by tree species composition, stand structure, and environmental conditions. Here, we investigated typical plantation types in the Mufu Mountain, Hubei Province.
Mingyang Ding, Yi Yang, Jiaoyang Xu, Shaoqiang Wang, Lunche Wang, Chunbo Huang   +5 more
wiley   +1 more source

Pan-cancer multi-omics dissection of podosome-related genes reveals their dual roles in tumor invasion and immune modulation. [PDF]

Discov Oncol
Xu D, He Y, Zhao P, Liao C, Tan J.
europepmc   +1 more source

Efficient First‐Principles Inverse Design of Nanolasers

Laser &Photonics Reviews, EarlyView.
This article introduces a first‐principles inverse‐design framework for nanolasers that directly incorporates nonlinear lasing physics. By unifying steady‐state ab‐initio laser theory (SALT) with topology optimization, it reveals how spatial hole burning, gain saturation, and cavity‐emitter coupling shape laser performance, enabling efficient discovery
Beñat Martinez de Aguirre Jokisch, Alexander Cerjan, Rasmus Ellebæk Christiansen, Jesper Mørk, Ole Sigmund, Steven G. Johnson   +5 more
wiley   +1 more source

Integrative molecular simulations reveal NeuroAid II mechanisms in ischemic stroke through network pharmacology, molecular dynamics, and pharmacophore modeling. [PDF]

Sci Rep
Dermawan D, Simatupang ST, Nadia N, Tan S, Tjandrawinata RR.   +4 more
europepmc   +1 more source

Dihydroartemisinin attenuates pemphigus vulgaris by regulating Dsg3 and the TLR9/NF-κB pathway. [PDF]

Am J Transl Res
Cui Y, Song S, Cheng Y, Hu C, Yang M, Wang W.   +5 more
europepmc   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Parkinson's Disease Patient‐Specific Striatum Organoids Show Hallmarks of Increased Inflammation

Movement Disorders, EarlyView.
Abstract Background Dopaminergic neurons from the substantia nigra pars compacta project their axons into the dorsal striatum, forming the nigrostriatal pathway. In Parkinson's disease (PD), dopaminergic terminals degenerate in the striatum, leading to dopamine depletion, which in turn causes alterations in the basal ganglia circuits that are essential
Kyriaki Barmpa, Claudia Saraiva, Alise Zagare, Mona Tuzza, Joseph Longworth, Elisa Zuccoli, Katrin Hufnagel, Florian Skwirblies, Ronny Schmidt, Dirk Brenner, Christoph Schröder, Jens C. Schwamborn   +11 more
wiley   +1 more source