Results 11 to 20 of about 512,141 (378)
The Role of the Src Homology 3-Src Homology 2 Interface in the Regulation of Src Kinases [PDF]
Journal of Biological Chemistry, 2001 The regulatory fragment of Src kinases, comprising Src homology (SH) 3 and SH2 domains, is responsible for controlled repression of kinase activity. We have used a multidisciplinary approach involving crystallography, NMR, and isothermal titration calorimetry to study the regulatory fragment of Fyn (FynSH32) and its interaction with a physiological ...
Arold, S.T. +6 more
openaire +5 more sources
Endogenous c-src as a determinant of the tumorigenicity of src oncogenes. [PDF]
Proceedings of the National Academy of Sciences, 1996 We have compared the tumorigenicity of two src oncogenes, v-src and c-src(527), whose respective protein products pp60v-src and pp60c-src(527) show a different spectrum of amino acid substitutions vis-à-vis the c-src protooncogene-encoded product pp60c-src.
Alexander A. Christou +4 more
openaire +3 more sources
Oncogene, 2004 More than a quarter of a century has elapsed since the identification of the c-src proto-oncogene. During that period, we have learned that cancer arises as the result of mutations in proto-oncogenes and tumor suppressor genes, and we are now seeing the first fruits of these discoveries, in the form of targeted therapies directed against activated ...
openaire +2 more sources
FUS-CHOP promotes invasion in myxoid liposarcoma through a SRC/FAK/RHO/ROCK-dependent pathway [PDF]
, 2017 Deregulated SRC/FAK signaling leads to enhanced migration and invasion in many types of tumors. In myxoid and round cell liposarcoma (MRCLS), an adipocytic tumor characterized by the expression of the fusion oncogene FUS-CHOP, SRC have been found as one ...
González, M. Victoria +3 more
core +2 more sources
Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor
Journal of Biological Chemistry, 1996 Here, we have studied the activity of a novel protein-tyrosine kinase inhibitor that is selective for the Src family of tyrosine kinases. We have focused our study on the effects of this compound on T cell receptor-induced T cell activation, a process ...
J. Hanke +7 more
semanticscholar +1 more source
Functional dissection of transformation by c‐Src and v‐Src [PDF]
Genes to Cells, 2007 The c‐src proto‐oncogene product, c‐Src, is frequently over‐expressed and activated in various human malignant cancers, implicating a role for c‐Src in cancer progression. To verify the role of c‐Src, we analyzed the transforming ability of c‐Src in mouse embryonic fibroblasts that lack Csk, a negative regulator of Src family kinases.
Chitose Oneyama +3 more
openaire +3 more sources
Study of hsa_circRNA_000121 and hsa_circRNA_004183 in papillary thyroid microcarcinoma
Open Life Sciences, 2022 We detected the expressions of hsa_circRNA_000121 and hsa_circRNA_ 004183 in papillary thyroid microcarcinoma (PTMC) and explored their relationship with the invasiveness of PTMC.
Bai Chao +4 more
doaj +1 more source
Regulation, targets and functions of CSK
Frontiers in Cell and Developmental Biology, 2023 The Src family kinases (SFK) plays an important role in multiple signal transduction pathways. Aberrant activation of SFKs leads to diseases such as cancer, blood disorders, and bone pathologies.
Shudong Zhu +3 more
doaj +1 more source
Probing short-range correlations in asymmetric nuclei with quasi-free pair knockout reactions [PDF]
, 2018 Short-range correlations (SRC) in asymmetric nuclei with an unusual neutron-to-proton ratio can be studied with quasi-free two-nucleon knockout processes following the collision between accelerated ions and a proton target.
Cosyn, Wim +3 more
core +3 more sources