Results 231 to 240 of about 260,978 (272)

Integrative network pharmacology and molecular modeling approaches reveal the therapeutic potential of <i>Syzygium samarangense</i> phytocompounds against diabetes retinopathy. [PDF]

Front Bioinform
Kandhan A, Mathew B, Thirugnanasambandam S.   +2 more
europepmc   +1 more source

The Complement System in Post‐Transplant Kidney Injury

Organ Medicine, EarlyView.
Mengsi Hu
wiley   +1 more source

A Triangulenum‐Based Biosensor Platform for Mapping Kinase Activity in T Cells

Small, EarlyView.
Novel peptide biosensors based on long‐lifetime triangulenium dyes are developed for the real‐time, non‐invasive mapping of Akt1 and Src kinase activities in living cells. Utilizing FLIM microscopy, these highly specific, biocompatible probes overcome cellular autofluorescence.
Carmen Salto‐Giron, Angélica Martín‐Priego, Francisco Fueyo‐González, María Mar Quesada‐Moreno, Federico Movilla, Antonio Reinoso, Laura Espinar‐Barranco, Rafael Salto, Amparo Navarro, Miguel Fribourg, Angel Orte, Juan A. González‐Vera   +11 more
wiley   +1 more source

CDDO-Me Overcomes Gefitinib Resistance in NSCLC by Targeting the Src/STAT3 Axis to Induce Apoptosis and Pyroptosis. [PDF]

Int J Mol Sci
Li T, Du W, Wang R, Yu X, Zhang B, Wang W, Xu J, Cao H, Tang D, Liu N.   +9 more
europepmc   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

The Src-Family Kinases Hck, Fgr and Lyn Drive Immune Complex-Mediated Glomerulonephritis Through the Syk Tyrosine Kinase. [PDF]

FASEB J
Lesinszki LS, Deli D, Boldizsár LK, Pánczél Á, Fintha A, Robson MG, Mócsai A.   +6 more
europepmc   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

BDNF-TrkB Signaling Engages a Src Family Kinase-Pannexin 1 Pathway During the Onset of Sustained Mechanical Hyperalgesia. [PDF]

Int J Mol Sci
Aránguiz Barrera J, Moreira-Banuth AM, Zepeda-Morales K, Triolo M, Oneto NI, Bravo D, Huidobro-Toro JP, Donoso MV, Noseda R, Pelissier T, Hernández A, Constandil L, Retamal JS.   +12 more
europepmc   +1 more source

Mechanical, rheological, and durability performances of GGBS‐based concrete for potential application to prestressed structures

Structural Concrete, EarlyView.
Abstract Ground granulated blast‐furnace slag (GGBS) is a widely used clinker substitute in concrete, recognized for its potential to significantly reduce environmental impacts. However, its application in prestressed concrete remains limited in several countries, mainly due to concerns regarding early‐age mechanical performance and long‐term ...
D. Rolando Baldiviezo, Leonardo Todisco, Cristina Argiz, Carmen Andrade, Amparo Moragues, Jaime C. Gálvez, Hugo Corres   +6 more
wiley   +1 more source