Results 21 to 30 of about 512,141 (378)
Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer
Nature, 2018 Alterations in both cell metabolism and transcriptional programs are hallmarks of cancer that sustain rapid proliferation and metastasis1. However, the mechanisms that control the interaction between metabolic reprogramming and transcriptional regulation
Subhamoy Dasgupta +14 more
semanticscholar +1 more source
SRChing for the substrates of Src [PDF]
Oncogene, 2013 By the mid 1980's, it was clear that the transforming activity of oncogenic Src was linked to the activity of its tyrosine kinase domain and attention turned to identifying substrates, the putative next level of control in the pathway to transformation.
Scott A. Weed +6 more
openaire +2 more sources
Cancer Cell, 2009 In this issue of Cancer Cell, Lowy and colleagues show that the SH2 domain of tensin-3 is regulated by phosphorylation by Src and that this phosphorylation promotes the oncogenic function of tensin-3. Phosphorylation of the SH2 domain represents a novel mechanism for the regulation of SH2 ligand binding.
openaire +3 more sources
Activation of MAPK signalling results in resistance to saracatinib (AZD0530) in ovarian cancer [PDF]
, 2017 SRC tyrosine kinase is frequently overexpressed and activated in late-stage, poor prognosis ovarian tumours, and preclinical studies have supported the use of targeted SRC inhibitors in the treatment of this disease.
El-Helali, Aya +6 more
core +2 more sources
SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis
Journal of Biological Chemistry, 2018 When properly employed, targeted therapies are effective cancer treatments. However, the development of such therapies requires the identification of targetable drivers of cancer development and metastasis.
John M. Lamar +7 more
semanticscholar +1 more source
LAMININS IN COLORECTAL CANCER: EXPRESSION, FUNCTION, PROGNOSTIC POWER AND MOLECULAR MECHANISMS
Исследования и практика в медицине, 2017 Extracellular matrix (ECM) proteins are a major component of the tumor stroma. Laminins emerge as one of the main families of ECM proteins with signaling properties.
S. A. Rodin, D. V. Maltseva
doaj +1 more source
Short-range correlations in (e,e$'$p) and (e,e$'$pp) reactions on complex nuclei [PDF]
, 1995 The influence of short-range correlations (SRC) on the triple-coincidence (e,e$'$pp) reactions is studied. The non-relativistic model uses a mean-field potential to account for the distortions that the escaping particles undergo. Apart from the SRC, that
Benhar +24 more
core +2 more sources
ESSENTIAL ROLE OF LYN IN FIBROSIS
Frontiers in Physiology, 2016 Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which deposit connective tissue, leading to obliteration of the function of the underlying organ.
Hung Pham +10 more
doaj +1 more source
SRC promotes lipogenesis: implications for obesity and breast cancer
Molecular & Cellular Oncology, 2021 Remodeling of lipid metabolism has been implicated in cancers; however, it remains obscure how the lipid metabolic pathways are altered by oncogenic signaling to affect tumor development. We have recently shown that proto-oncogene tyrosine-protein kinase
Shu-Yong Lin, Sheng-Cai Lin
doaj +1 more source
Frontiers in Oncology, 2015 Aurora-A kinase (AURKA) overexpression in numerous tumors induces aneuploidy, in part because of cytokinetic defects. Alisertib and other small-molecule inhibitors targeting AURKA are effective in some patients as monotherapies or combination therapies.
Anna S Nikonova +7 more
doaj +1 more source