Results 51 to 60 of about 451,893 (254)

Src Inhibition Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation and Decreasing Connective Tissue Growth Factor

Cells, 2020
The SRC kinase family comprises non-receptor tyrosine kinases that are ubiquitously expressed in all cell types. Although Src is reportedly activated in pulmonary and renal fibrosis, little is known regarding its role in liver fibrosis.
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Yu Na Kang, Jae Seok Hwang, Keun-Gyu Park, Mi Kyung Kim, Byoung Kuk Jang   +7 more
doaj   +1 more source

The forgotten threat of cholera in Syria

Journal of Water and Health, 2022
Cholera is an ancient disease that persists as an issue of public health in many conflict-affected countries worldwide. Cholera is a diarrheal infection caused by ingested water or food contaminated with the bacterium Vibrio cholerae.
Orwa Al-Abdulla, Maher Alaref
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]

, 2014
Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean, Maunze, Brian, Phillips, Kailynn A., Resch, Jon M   +3 more
core   +2 more sources

Theories, techniques and strategies of sustainable circular economy: a systematic literature review

Discover Sustainability
This systematic literature review paper provides an extensive understanding of the circular economy and sustainability for the various manufacturing sectors. The papers were taken from Scopus and Google Scholar for this systematic review.
R. Purushothaman, R. Alamelu, S. Selvabaskar, M. Sudha   +3 more
doaj   +1 more source

Opposing effects of inhibitors of Aurora-A and EGFR in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Frontiers in Oncology, 2015
Aurora-A kinase (AURKA) overexpression in numerous tumors induces aneuploidy, in part because of cytokinetic defects. Alisertib and other small-molecule inhibitors targeting AURKA are effective in some patients as monotherapies or combination therapies.
Anna S Nikonova, Alexander Y Deneka, Alexander Y Deneka, Louisa eEckman, Meghan C Kopp, Harvey H Hensley, Brian L Egleston, Erica eGolemis   +7 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Prostaglandin E2-dependent activation of Src-Stat3 signal pathway in human lung adenocarcinoma cells

Czech Journal of Food Sciences, 2004
Accumulating evidence suggests that overproduction of prostaglandin (PG) E2 attributable to induction of cyclooxygenase-2 plays an important role in the development of lung adenocarcinoma.
I. Nagamine, T. Yano, K. Endoh, T. Yamaki, T. Morimura, M. Miyahara, H. T. T. Nguyen, J. Pokorný, H. Sakurai   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Potential impacts on ecosystem services of land use transitions to second-generation bioenergy crops in GB [PDF]

, 2015
We present the first assessment of the impact of land use change (LUC) to second-generation (2G) bioenergy crops on ecosystem services (ES) resolved spatially for Great Britain (GB).
Albaladejo, Alexander, Arima, Aylott, Barnett, Bateman, Bianchi, Blanco-Canqui, Boardman, Borzecka-Walker, Bosatta, Bourke, Busch, Börjesson, Clifton-Brown, Clifton-Brown, Coleman, Dauber, Davis, Dockerty, Dondini, Donnelly, Eigenbrod, FAO/Iiasa/ISRIC/Isscas/JRC, Fargione, Finch, Godfray, Hansen, Hastings, Hastings, Hastings, Hastings, Hillier, Holland, Kang, Lattimore, Le, Lovett, Lovett, Manning, Matthews, Metzger, Plevin, Rathmann, Rowe, Rowe, Rowe, Schulze, Searchinger, Selman, Semere, Semere, Smith, St Clair, Tallis, Tilman, Tirado, UK National Ecosystem Assessment, Updegraff, Upham, Valentine, Vanloocke, Wang, Wang, Werling, Whitaker, Wynn, Yan, Zatta, Zimmermann   +69 more
core   +2 more sources