Results 61 to 70 of about 451,893 (254)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Improving Sparse Representation-Based Classification Using Local Principal Component Analysis

, 2018
Sparse representation-based classification (SRC), proposed by Wright et al., seeks the sparsest decomposition of a test sample over the dictionary of training samples, with classification to the most-contributing class.
A. Singer, A.S. Georghiades, Chia-Po Wei, Christian Merkwirth, Claudio Ceruti, David L. Donoho, Hakan Cevikalp, Hongzhi Zhang, J. Wright, Jadoon Waqas, Jon Louis Bentley, Jun Yin, L Qiao, N Kambhatla, Patrice Y. Simard, R Patel, ST Roweis, Xiaoyang Tan, Y LeCun, Yong Xu, Zechao Li   +20 more
core   +1 more source

ESSENTIAL ROLE OF LYN IN FIBROSIS

Frontiers in Physiology, 2016
Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which deposit connective tissue, leading to obliteration of the function of the underlying organ.
Hung Pham, Chiara Birtolo, Chintan Chheda, Wendy Yang, Maria Rodriguez, Sandy Liu, Gabriele Gugliotta, Michael Lewis, Vincenzo Cirulli, Stephen Pandol, Andrzej Ptasznik   +10 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Extracting the Mass Dependence and Quantum Numbers of Short-Range Correlated Pairs from A(e,e'p) and A(e,e'pp) Scattering

, 2015
The nuclear mass dependence of the number of short-range correlated (SRC) proton-proton (pp) and proton-neutron (pn) pairs in nuclei is a sensitive probe of the dynamics of short-range pairs in the ground state of atomic nuclei.
Colle, C., Cosyn, W., Hen, O., Korover, I., Piasetzky, E., Ryckebusch, J., Weinstein, L. B.   +6 more
core   +1 more source

In Silico Analysis To Explore Novel Inhibitors For Human Proto-oncogene Tyrosine Protein Kinase Src [PDF]

, 2010
The first oncogene and the first non receptor tyrosine kinase, Src, plays a key role in cell morphology, motility, proliferation and survival. Over expression of Src kinase activity disrupts the RAS pathway in signaling pathway, where it loses its ...
Amineni Umamaheswari, Dibyabhaba Pradhan, Nagapriya Mahanandi   +2 more
core   +2 more sources

Interplay of Matrix Stiffness and c-SRC in Hepatic Fibrosis.

Frontiers in Physiology, 2015
Introduction:In liver fibrosis activation of hepatic stellate cells (HSC) comprises phenotypical change into profibrotic and myofibroplastic cells with increased contraction and secretion of extracellular matrix (ECM) proteins.
Jan eGörtzen, Robert eSchierwagen, Jeanette eBierwolf, Sabine eKlein, Frank Erhard Uschner, Peter F. van der Ven, Dieter O. Fürst, Christian P. Strassburg, Wim eLaleman, Jörg-Matthias ePollok, Jonel eTrebicka, Jonel eTrebicka   +11 more
doaj   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Water temperature as a natural tracer – a case study of the Malenščica karst spring (SW Slovenia)

Geologia Croatica, 2010
For the adequate protection of karst springs it is important to understand the functioning of karst systems in their recharge areas. Besides tracer tests with artificial tracers, tracings with natural tracers, such as temperature, are a very useful ...
Metka Petrič, Janja Kogovšek
doaj   +1 more source

Laboratory diagnosis of nonpolio enteroviruses: A review of the current literature

Biosafety and Health, 2023
Infections by nonpolio enteroviruses (EVs) are highly prevalent, particularly among children and neonates, where they may cause substantial morbidity and mortality.
Tarek Itani, Vladislav Chalapa, Aleksandr Semenov, Aleksandr Sergeev   +3 more
doaj   +1 more source