Results 41 to 50 of about 44,786 (250)
Cloning and Characterization of Bovine Sry Gene
Nihon Chikusan Gakkaiho, 1995 哺乳類における性決定因子とは精巣決定因子(ヒトではTDF,動物ではTdy)であり,その本体はSRY/Sry遺伝子と考えられている.PCRで増幅したヒトSRY遺伝子の一部をプローブとしてウシのゲノムライブラリーをスクリーニングすることによりウシのSry遺伝子を含むクローンを得た.HincIIおよびBamHI部位に挟まれた2.8kbのDNA断片を検索し,進化的に保存されているHMG (High mobility group)ボックスを含めウシSry遺伝子の5'上流および3'下流の塩基配列を決定した.HMGボックスならびにその5'側上流および3'側下流領域のプライマーDNAを合成し,ホルスタイン,F1牛(ホルスタイン雌,和牛雄),ヒツジ,ヤギ,およびマウスの雌雄DNAを鋳型としてPCRを行なったところ ...
Yuko KATO +4 more
openaire +2 more sources
A method for isolating and culturing placental cells from failed early equine pregnancies [PDF]
, 2016 Early pregnancy loss occurs in 6–10% of equine pregnancies making it the main cause of reproductive wastage. Despite this, reasons for the losses are known in only 16% of cases.
A.J. McGladdery +31 more
core +2 more sources
PCR amplification of SRY-related gene sequences reveals evolutionary conservation of the SRY-box motif. [PDF]
Genome Research, 1993 SRY (sex-determining region of the Y chromosome) has recently been identified as a key regulatory gene in mammalian sex determination. The open reading frame of this gene contains an 80-amino-acid motif, the SRY-box, which shares a high degree of homology with a DNA-binding domain found in the high-mobility-group (HMG) proteins HMG1 and HMG2.
A M, Coriat +4 more
openaire +2 more sources
Detection of skewed X-chromosome inactivation in Fragile X syndrome and X chromosome aneuploidy using quantitative melt analysis. [PDF]
, 2015 Methylation of the fragile X mental retardation 1 (FMR1) exon 1/intron 1 boundary positioned fragile X related epigenetic element 2 (FREE2), reveals skewed X-chromosome inactivation (XCI) in fragile X syndrome full mutation (FM: CGG > 200) females ...
Amor, David J +13 more
core +2 more sources
Experimental and Molecular Medicine, 2019 Bone health: Insight into gender differences in osteoporosis A male-specific gene offers clues to diagnosis and treatment of age-related osteoporosis.
Klemen Kodrič +6 more
doaj +1 more source
Of sex and determination: marking 25 years of Randy, the sex-reversed mouse [PDF]
, 2016 On Thursday 9 May 1991, the world awoke to front-page news of a breakthrough in biological research. From Washington to Wollongong, newspapers, radio and TV were abuzz with the story of a transgenic mouse in London called Randy.
Koopman, Peter +2 more
core +1 more source
BMC Medical Genetics, 2010 Background Sex determining factor (SRY) located on the short arm of the Y chromosome, plays an important role in initiating male sex determination, resulting in development of testicular tissue.
Batra Swaraj +6 more
doaj +1 more source
Journal of Reproduction and Development, 1996 In mammals, the SRY (the sex determining region on the Y; Sry in the mouse) gene is responsible for the function of TDF (testis determining factor; Tdy in the mouse) locus, and plays a key role in the sex determination. In the mouse, the Sry open reading frame (ORF) is flanked at either end by a large inverted repeat, causing the formation of ...
Osamu HIROTA +7 more
openaire +2 more sources
Mutations in the SRY, DAX1, SF1 and WNT4 genes in Brazilian sex-reversed patients
Brazilian Journal of Medical and Biological Research, 2004 In most mammals, male development is triggered by the transient expression of the SRY gene, which initiates a cascade of gene interactions ultimately leading to the formation of a testis from the indifferent fetal gonad.
S. Domenice +6 more
doaj +1 more source
Revista Colombiana de Biotecnología, 2016 Freemartin syndrome is a intersexuality condition developed in many of the female calfs born from heterosexual multiple calvings (male female). This originates in the fetal development between 30 and 40 days of gestation with transplacental exchange of ...
Ximena Cardona Lopera +3 more
doaj +1 more source