Results 1 to 10 of about 1,430 (102)

Diversity in the Characteristics of Klebsiella pneumoniae ST101 of Human, Environmental, and Animal Origin

Frontiers in Microbiology, 2022
BackgroundKlebsiella pneumoniae ST101 is an emerging high-risk clone which exhibits extensive drug resistance. Bacterial strains residing in multiple hosts show unique signatures related to host adaptation.
Sien De Koster, Christine Lammens, Herman Goossens   +2 more
exaly   +3 more sources

The Novel Cognitive Enhancer ST101 Enhances Acetylcholine Release in Mouse Dorsal Hippocampus Through T-type Voltage-Gated Calcium Channel Stimulation

Journal of Pharmacological Sciences, 2013
We recently developed a novel cognitive enhancer, ST101 (spiro[imidazo[1,2-a] pyridine-3,2-indan]-2(3H)-one), that activates T-type voltage-gated calcium channels (VGCCs).
Yui Yamamoto, Norifumi Shioda, Shigeki Moriguchi   +2 more
exaly   +3 more sources

Diversity, Virulence, and Antimicrobial Resistance in Isolates From the Newly Emerging Klebsiella pneumoniae ST101 Lineage

Frontiers in Microbiology, 2019
The global dissemination of Klebsiella pneumoniae and Klebsiella pneumoniae carbapenemase (KPC) has been largely attributed to a few high-risk sequence types (STs) (ST258, ST11, ST512) associated with human disease.
Chandler C Roe, Adam J Vazquez, Eliana Pia Esposito   +2 more
exaly   +3 more sources

Cognitive enhancer ST101 improves schizophrenia-like behaviors in neonatal ventral hippocampus-lesioned rats in association with improved CaMKII/PKC pathway

Journal of Pharmacological Sciences, 2019
Atypical antipsychotics improve positive and negative symptoms but are not effective for treating cognitive impairments in patients with schizophrenia. We previously reported that cognitive impairments in neonatal ventral hippocampus (NVH)-lesioned rats ...
Yasushi Yabuki, Kohji Fukunaga
exaly   +3 more sources

Meropenem/vaborbactam activity against carbapenem-resistant Klebsiella pneumoniae from catheter-related bloodstream infections [PDF]

Frontiers in Cellular and Infection Microbiology
IntroductionCarbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant threat in oncology settings due to its multidrug resistance and ability to form biofilms on indwelling medical devices.MethodsThis study investigated the in vitro and in ...
Francesca Sivori, Massimo Francalancia, Mauro Truglio, Ilaria Cavallo, Carmelina Pronesti, Giorgia Fabrizio, Ilaria Celesti, Andrea Cazzani, Lorenzo Furzi, Fulvia Pimpinelli, Enea Gino Di Domenico   +10 more
doaj   +2 more sources

Genomic Epidemiology of Carbapenem- and Colistin-Resistant Klebsiella pneumoniae Isolates From Serbia: Predominance of ST101 Strains Carrying a Novel OXA-48 Plasmid

Frontiers in Microbiology, 2020
Klebsiella pneumoniae is a major cause of severe healthcare-associated infections and often shows MDR phenotypes. Carbapenem resistance is frequent, and colistin represents a key molecule to treat infections caused by such isolates. Here we evaluated the
Marco Maria D’Andrea, Snezana Brkic, Ivana Cirkovic   +2 more
exaly   +3 more sources

Emerging high-risk ST101 and ST307 carbapenem-resistant Klebsiella pneumoniae clones from bloodstream infections in Southern Italy

Annals of Clinical Microbiology and Antimicrobials, 2020
Background Carbapenem-resistant Klebsiella pneumoniae (CR-KP) is an urgent public health issue in Italy. This pattern of resistance is due mainly to dissemination of carbapenemase genes.
Daniela Loconsole, Anna Lisa De Robertis, Loredana Capozzi   +2 more
exaly   +3 more sources

Antimicrobial resistance, virulence defects, and evolutionary dynamics of multidrug-resistant Klebsiella pneumoniae from human and animal hosts in Central China [PDF]

Microbiology Spectrum
The global dissemination of multidrug-resistant Klebsiella pneumoniae (MDR-KP) poses a critical One Health challenge. This study investigated the antimicrobial resistance (AMR) profiles, virulence determinants, and zoonotic transmission risks of K ...
Wen Sun, Xiaoman Zhu, Xiaomin Pang, Xiangyun Wu, Qian Guo, Linshen Li, Baojing Dou, Yulian Wang   +7 more
doaj   +2 more sources

Multidrug Resistant Klebsiella pneumoniae ST101 Clone Survival Chain From Inpatients to Hospital Effluent After Chlorine Treatment

Frontiers in Microbiology, 2021
In this paper we describe the transmission of a multi-drug resistant Klebsiella pneumoniae ST101 clone from hospital to wastewater and its persistence after chlorine treatment.
Laura Ioana Popa, Irina Gheorghe, Ilda Czobor Barbu   +2 more
exaly   +3 more sources

Co-existence of plasmid-mediated blaNDM-1 and blaNDM-5 in Escherichia coli sequence type 167 and ST101 and their discrimination through restriction digestion [PDF]

Microbiology Spectrum
The concurrent presence of multiple New Delhi metallo-β-lactamase (blaNDM) variants within an isolate often goes undetected without next-generation sequencing.
Amrita Bhattacharjee, Priyanka Basak, Shravani Mitra, Jagannath Sarkar, Shanta Dutta, Sulagna Basu   +5 more
doaj   +2 more sources