Results 11 to 20 of about 34,767 (273)

Profiling of Tregs across tissues reveals plasticity in ST2 expression and hierarchies in tissue-specific phenotypes

iScience, 2022
Summary: Foxp3+ regulatory T cells (Tregs) are critical mediators of peripheral tolerance and immune homeostasis and exert tissue-specific functions. In many nonlymphoid tissues, Tregs show enriched expression of the IL-33 receptor ST2.
Sabine Spath, Florence Roan, Scott R. Presnell, Barbara Höllbacher, Steven F. Ziegler   +4 more
doaj   +2 more sources

ST2 IN REJECTION OF THE TRANSPLANTED HEART [PDF]

Вестник трансплантологии и искусственных органов, 2016
This review summarizes the current literature devoted to the analysis of prognostic role of ST2 biomarker in rejection of the transplanted heart. ST2 is one of the most promising diagnostic markers of the development and severity of heart failure as well
O. P. Shevchenko, A. A. Ulybysheva, D. A. Velikiy, A. O. Shevchenko   +3 more
doaj   +2 more sources

IL-33/ST2 signalling promotes tumor growth by regulating polarization of alternatively activated macrophages

Cancer Biology & Medicine
Objective: Suppression of tumorigenicity 2 (ST2), the receptor for interleukin (IL)-33, has a critical role in tumor growth, angiogenesis, metastasis, and immune modulation.
Liping Liu, Haoge Luo, Yingdong Xie, Ying Wang, Shiying Ren, Haiyang Sun, Dong Li   +6 more
doaj   +2 more sources

Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-Induced Septic Arthritis [PDF]

Frontiers in Immunology, 2018
The ST2 receptor is a member of the Toll/IL-1R superfamily and interleukin-33 (IL-33) is its agonist. Recently, it has been demonstrated that IL-33/ST2 axis plays key roles in inflammation and immune mediated diseases. Here, we investigated the effect of
Larissa Staurengo-Ferrari, Silvia C. Trevelin, Silvia C. Trevelin, Victor Fattori, Daniele C. Nascimento, Kalil A. de Lima, Jacinta S. Pelayo, Florêncio Figueiredo, Rubia Casagrande, Sandra Y. Fukada, Mauro M. Teixeira, Thiago M. Cunha, Foo Y. Liew, Rene D. Oliveira, Paulo Louzada-Junior, Fernando Q. Cunha, José C. Alves-Filho, Waldiceu A. Verri   +17 more
doaj   +2 more sources

Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression [PDF]

Frontiers in Immunology, 2019
Oral T. gondii infection (30 cysts of 76K strain) induces acute lethal ileitis in sensitive C57BL/6 (B6) mice with increased expression of IL-33 and its receptor ST2 in the ileum.
Bernhard Ryffel, Bernhard Ryffel, Feng Huang, Pauline Robinet, Corine Panek, Isabelle Couillin, François Erard, Julie Piotet, Marc Le Bert, Claire Mackowiak, Marbel Torres Arias, Isabelle Dimier-Poisson, Song Guo Zheng   +12 more
doaj   +2 more sources

The ST2+ Treg/amphiregulin axis protects from immune-mediated hepatitis [PDF]

Frontiers in Immunology
IntroductionThe alarmin IL-33 has been implicated in the pathology of immune-mediated liver diseases. IL-33 activates regulatory T cells (Tregs) and type 2 innate lymphoid cells (ILC2s) expressing the IL-33 receptor ST2.
Selina Wachtendorf, Selina Wachtendorf, Fitriasari Jonin, Fitriasari Jonin, Aaron Ochel, Fabian Heinrich, Astrid M. Westendorf, Gisa Tiegs, Gisa Tiegs, Katrin Neumann, Katrin Neumann   +10 more
doaj   +2 more sources

IL-33/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential [PDF]

Frontiers in Immunology
Interleukin-33 (IL-33) is a nuclear factor and member of the IL-1 cytokine family. IL-33 is mainly expressed by epithelial and endothelial cells and exerts its function through interaction with various immune cells, and binding to its receptor can form ...
Feiya Sheng, Mi Li, Jia-Mei Yu, Si-Yu Yang, Liang Zou, Guan-Jun Yang, Le-Le Zhang, Le-Le Zhang   +7 more
doaj   +2 more sources

A helminth-derived suppressor of ST2 blocks allergic responses [PDF]

, 2020
The IL-33-ST2 pathway is an important initiator of type 2 immune responses. We previously characterised the HpARI protein secreted by the model intestinal nematode Heligmosomoides polygyrus, which binds and blocks IL-33. Here, we identify H.
Adefunke Ogunkanbi, Caroline Chauché, Graham Heieis, Chauché, Caroline, Nys, Josquin A., Vacca, Francesco, Webster, Holly, Cohen, E. Suzanne, McSorley, Henry J.; id_orcid, Hinchy, Elizabeth C., Perona-Wright, Georgia, Higgins, Matthew K., Mcsorley, Henry J, Abhishek Jamwal, Henry J McSorley, Wear, Martin A., William F Gregory, Zala Sekne, Holly Webster, Hinchy, Elizabeth C, Cohen, E Suzanne, Ogunkanbi, Adefunke, Gregory, William F., Elizabeth C Hinchy, McSorley, Henry J., Nys, Josquin A, Francesco Vacca, Gregory, William F, Martin Wear, Heieis, Graham, Matthew K Higgins, Higgins, Matthew K ., E Suzanne Cohen, Sekne, Zala, Georgia Perona-Wright, Nys, Josquin, Jamwal, Abhishek, Josquin A Nys, Wear, Martin, Higgins, Matthew K   +39 more
core   +5 more sources

Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia [PDF]

, 2012
<b>Objective—</b><p></p> The p75 neurotrophin receptor (p75^NTR) contributes to diabetes mellitus−induced defective postischemic neovascularization.
Spinetti, Gaia, Ambra Gotti, Losa, Sergio, Christa Noehammer, Ezio Faglia, Orazio Fortunato, Caporali, Andrea, Emanueli, Costanza, Nailor, Audrey, Cardinali, Alessandro Cardinali, Alessandro Cardinali, Manuela Hofner, Noehammer, Christa, Sergio Losa, Gotti, Ambra, Miller, Ashley M, Vierlinger, Klemens, Fortunato, Orazio, Ashley M. Miller, Tijana Mitić, Costanza Emanueli, Miller, Ashley M., Hofner, Manuela, Caporali, Andrea; id_orcid, Cardinali, Alessandro, Meloni, Marco, Paolo Madeddu, Gaia Spinetti, Faglia, Ezio, Klemens Vierlinger, Audrey Nailor, Mitić, Tijana, Andrea Caporali, Madeddu, Paolo, Marco Meloni   +34 more
core   +1 more source

IL-33/ST2 axis in organ fibrosis [PDF]

, 2018
Interleukin 33 (IL-33) is highly expressed in barrier sites, acting via the suppression of tumorigenicity 2 receptor (ST2). IL-33/ST2 axis has long been known to play a pivotal role in immunity and cell homeostasis by promoting wound healing and tissue ...
Kotsiou O.S., Gourgoulianis K.I., Zarogiannis S.G.
core   +2 more sources