Results 31 to 40 of about 22,553 (226)

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

ST2 IN REJECTION OF THE TRANSPLANTED HEART

Вестник трансплантологии и искусственных органов, 2016
This review summarizes the current literature devoted to the analysis of prognostic role of ST2 biomarker in rejection of the transplanted heart. ST2 is one of the most promising diagnostic markers of the development and severity of heart failure as well
O. P. Shevchenko, A. A. Ulybysheva, D. A. Velikiy, A. O. Shevchenko   +3 more
doaj   +1 more source

IL-33 Receptor-Expressing Regulatory T Cells Are Highly Activated, Th2 Biased and Suppress CD4 T Cell Proliferation through IL-10 and TGFβ Release. [PDF]

PLoS ONE, 2016
Immunomodulatory Foxp3+ regulatory T cells (Tregs) form a heterogeneous population consisting of subsets with different activation states, migratory properties and suppressive functions.
Julia Siede, Anja Fröhlich, Angeliki Datsi, Ahmed N Hegazy, Domonkos V Varga, Vivien Holecska, Hirohisa Saito, Susumu Nakae, Max Löhning   +8 more
doaj   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

A Correlative SICM‐OPM Platform for Surface and Volumetric Imaging in Live Cells

Advanced Science, EarlyView.
A multifunctional correlative imaging platform integrating Scanning Ion Conductance Microscopy (SICM) with Oblique Plane Microscopy (OPM) enables simultaneous surface topography, mechanical mapping, and 3D volumetric fluorescence imaging in live cells.
Wenzhi Hong, Ziwei Zhang, Ao Li, Ting Sun, Yunzhao Wu, Devkee M. Vadukul, Dylan Jones, Bing Li, Fengjie Liu, Francesco A. Aprile, Yuri Korchev, Julia Gorelik, David Klenerman, Andrew Shevchuk   +13 more
wiley   +1 more source

The Role of ST2 Receptor in the Regulation of Brucella abortus Oral Infection

Pathogens, 2020
The ST2 receptor plays an important role in the gut such as permeability regulation, epithelium regeneration, and promoting intestinal immune modulation. Here, we studied the role of ST2 receptor in a murine model of oral infection with Brucella abortus,
Raiany Santos, Priscila C. Campos, Marcella Rungue, Victor Rocha, David Santos, Viviani Mendes, Fabio V. Marinho, Flaviano Martins, Mayra F. Ricci, Diego C. dos Reis, Geovanni D. Cassali, José Carlos Alves-Filho, Angelica T. Vieira, Sergio C. Oliveira   +13 more
doaj   +1 more source

Optimal Indication of D3 Lymph Node Dissection for Non‐Metastatic Colon Cancers by Tumor Stages: Evaluation of Therapeutic Value Index for Each Lymph Node Station

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aims To explore the therapeutic impact of D3 lymph node dissection for non‐metastatic colon cancers, evaluating the therapeutic value index for each lymph node station according to surgical stages. Methods Consecutive patients with surgical Stage I–III colon and rectosigmoid cancer who underwent curative resection between January 2003 and ...
Akira Ouchi, Kozo Kataoka, Eiji Shinto, Takashi Akiyoshi, Takefumi Yoshida, Yasuyuki Takamizawa, Yukihide Kanemitsu, Hirotoshi Kobayashi, Hideki Ueno, on behalf of the Lymph Nodes Committee of JSCCR   +9 more
wiley   +1 more source

IL-33 increases ST2+ Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner

OncoImmunology, 2019
Regulatory T cells (Tregs) facilitate primary and metastatic tumour growth through the suppression of anti-tumour immunity. Emerging evidence suggests a distinct role for Tregs in mediating tissue repair and barrier integrity in the lungs by IL-33 ...
E.C. Halvorsen, S.E. Franks, B.J. Wadsworth, B.T. Harbourne, R.A. Cederberg, C.A. Steer, I. Martinez-Gonzalez, J. Calder, W.W. Lockwood, K.L. Bennewith   +9 more
doaj   +1 more source

Data‐Driven Review and Machine Learning Prediction of Diamond Vacancy Center Synthesis

Advanced Intelligent Systems, EarlyView.
A machine learning framework is applied to photoluminescence spectra to extract linewidths and uncover how NV, SiV, GeV, and SnV centers evolve with growth and processing conditions. Unified normalization and k‐fold validation reveal cross‐method trends and enable rapid prediction of defect size and fabrication parameters, offering a data‐driven route ...
Zhi Jiang, Marco Peres, Carlo Bradac, Gil Gonçalves   +3 more
wiley   +1 more source

Soluble form of the ST2 gene product exhibits growth promoting activity in NIH-3T3 cells

Biochemistry and Biophysics Reports, 2016
The ST2 gene is induced in murine fibroblast cells at the start of cell proliferation. Although IL-33 has been identified as a ligand for one of the two major gene products of ST2 – namely, the transmembrane receptor form ST2L – prompting immunological ...
Shin-ichi Tominaga, Satoshi Ohta, Kenji Tago   +2 more
doaj   +1 more source