Results 51 to 60 of about 33,191 (261)

Inflammatory Signatures Beyond Th1/Th2 Endotypes Provide Insights Into Postoperative Recurrence in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) represents a spectrum of inflammatory endotypes, driven by distinct T helper (Th) immune responses. The high rate of recurrent disease despite appropriate medical and surgical interventions highlights the need for improved characterization beyond the traditional type 2 and non‐type 2 phenotypes to better
Liyona Kampel, Narin N. Carmel, Shaun Edalati, Hen Chaushu, Forsan Jahshan, Yaniv Hadi, Timur Pestrikov, Leonor Leider Trejo, Nidal Muhanna, Avraham Abergel   +9 more
wiley   +1 more source

Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation

, 2015
Interleukin-33 (IL-33) but not soluble ST2 (sST2) exerts anti-inflammatory and protective effects in several tissues. Aldosterone, a proinflammatory mediator which promotes adipogenesis, is elevated in obese patients.
Cachofeiro Ramos, María Victoria, López-Andrés N, Martínez Martínez, Ernesto   +2 more
core   +1 more source

IL-33 increases ST2+ Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner

OncoImmunology, 2019
Regulatory T cells (Tregs) facilitate primary and metastatic tumour growth through the suppression of anti-tumour immunity. Emerging evidence suggests a distinct role for Tregs in mediating tissue repair and barrier integrity in the lungs by IL-33 ...
E.C. Halvorsen, S.E. Franks, B.J. Wadsworth, B.T. Harbourne, R.A. Cederberg, C.A. Steer, I. Martinez-Gonzalez, J. Calder, W.W. Lockwood, K.L. Bennewith   +9 more
doaj   +1 more source

The Role of ST2 Receptor in the Regulation of Brucella abortus Oral Infection

Pathogens, 2020
The ST2 receptor plays an important role in the gut such as permeability regulation, epithelium regeneration, and promoting intestinal immune modulation. Here, we studied the role of ST2 receptor in a murine model of oral infection with Brucella abortus,
Raiany Santos, Priscila C. Campos, Marcella Rungue, Victor Rocha, David Santos, Viviani Mendes, Fabio V. Marinho, Flaviano Martins, Mayra F. Ricci, Diego C. dos Reis, Geovanni D. Cassali, José Carlos Alves-Filho, Angelica T. Vieira, Sergio C. Oliveira   +13 more
doaj   +1 more source

The IL-33/ST2 axis affects tumor growth by regulating mitophagy in macrophages and reprogramming their polarization

Cancer Biology & Medicine, 2021
Objective: Macrophages are a major component of the tumor microenvironment. M1 macrophages secrete pro-inflammatory factors that inhibit tumor growth and development, whereas tumor-associated macrophages (TAMs) mainly exhibit an M2 phenotype.
Huadan Xu, Dong Li, Jiaoyan Ma, Yuanxin Zhao, Long Xu, Rui Tian, Yanan Liu, Liankun Sun, Jing Su   +8 more
doaj   +1 more source

Pulmonary Production of Soluble ST2 in Heart Failure [PDF]

Circulation: Heart Failure, 2018
Background: Serum concentrations of ST2 (interleukin-1 receptor-like 1) represent a meaningful prognostic marker in cardiac diseases. Production of soluble ST2 (sST2) may be partially extracardiac. Identification of sST2 sources is relevant to design strategies for modulating its signaling.
Pascual Figal, Domingo Andrés, Pérez Martínez, María T, Asensio López, María del Carmen, Sánchez Mas, Jesús, García García, María E, Martínez, Carlos M, Lencina, Miriam, Jara, Ruben, Januzzi, James L, Lax Pérez, Antonio Manuel   +9 more
openaire   +2 more sources

Miller_et_al_ST1-ST2

, 2018
Supplementary tables for Miller_et_al 2017 that include genbank ...
Breinholt, Jesse W., Ogden, T. Heath, T. Heath Ogden (7064555), Stephanie Bartlett (7064552), Michel Sartori (351489), Dustin B. Miller (7064549), Jesse W. Breinholt (7851209), Bartlett, Stephanie, Sartori, Michel, Miller, Dustin B.   +9 more
core   +1 more source

ST2 in Stable and Unstable Ischemic Heart Diseases [PDF]

, 2015
Circulating suppression of tumorigenicity 2 (ST2) predicts cardiovascular outcomes and mortality in ischemic heart disease (IHD). ST2 does not correlate with traditional risk indicators as closely as N-terminal pro–brain natriuretic peptide (NT-proBNP ...
DI SOMMA, Salvatore, Mueller T., Richards AM   +2 more
core   +1 more source

The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer. [PDF]

, 2019
The composition of immune infiltrates strongly affects the prognosis of patients with colorectal cancer (CRC). Interleukin (IL)-33 and regulatory T cells (Tregs) in the tumor microenvironment have been separately implicated in CRC; however their ...
Muggli, Beat, Palmieri, Vittoria, Hansen, Wiebke, Buer, Jan, Krebs, Philippe, Pastille, Eva, Schuler, Martin, Zlobec, Inti, Westendorf, Astrid M, Phuong, Nhi Ngo Thi, Wasmer, Marie-Hélène Christin, Adamczyk, Alexandra, Simillion, Cedric André Marie, Mager, Lukas F, McCoy, Kathy D, Kasper, Stefan, Vu, Vivian Pham   +16 more
core   +2 more sources

Soluble form of the ST2 gene product exhibits growth promoting activity in NIH-3T3 cells

Biochemistry and Biophysics Reports, 2016
The ST2 gene is induced in murine fibroblast cells at the start of cell proliferation. Although IL-33 has been identified as a ligand for one of the two major gene products of ST2 – namely, the transmembrane receptor form ST2L – prompting immunological ...
Shin-ichi Tominaga, Satoshi Ohta, Kenji Tago   +2 more
doaj   +1 more source