Results 61 to 70 of about 30,785 (250)

IL-33 Receptor-Expressing Regulatory T Cells Are Highly Activated, Th2 Biased and Suppress CD4 T Cell Proliferation through IL-10 and TGFβ Release. [PDF]

PLoS ONE, 2016
Immunomodulatory Foxp3+ regulatory T cells (Tregs) form a heterogeneous population consisting of subsets with different activation states, migratory properties and suppressive functions.
Julia Siede, Anja Fröhlich, Angeliki Datsi, Ahmed N Hegazy, Domonkos V Varga, Vivien Holecska, Hirohisa Saito, Susumu Nakae, Max Löhning   +8 more
doaj   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

ST2 in Stable and Unstable Ischemic Heart Diseases [PDF]

, 2015
Circulating suppression of tumorigenicity 2 (ST2) predicts cardiovascular outcomes and mortality in ischemic heart disease (IHD). ST2 does not correlate with traditional risk indicators as closely as N-terminal pro–brain natriuretic peptide (NT-proBNP ...
DI SOMMA, Salvatore, Mueller T., Richards AM   +2 more
core   +1 more source

Wnt3a-induced ST2 decellularized matrix ornamented PCL scaffold for bone tissue engineering [PDF]

, 2022
The limited bioactivity of scaffold materials is an important factor that restricts the development of bone tissue engineering. Wnt3a activates the classic Wnt/β-catenin signaling pathway which effects bone growth and development by the accumulation of β-
Ma, Yufei, Wang, Xiaofang, Song, Yang, Liu, Guangliang, Tu, Xiaolin, Chen, Jie   +5 more
core   +1 more source

Optimal Indication of D3 Lymph Node Dissection for Non‐Metastatic Colon Cancers by Tumor Stages: Evaluation of Therapeutic Value Index for Each Lymph Node Station

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aims To explore the therapeutic impact of D3 lymph node dissection for non‐metastatic colon cancers, evaluating the therapeutic value index for each lymph node station according to surgical stages. Methods Consecutive patients with surgical Stage I–III colon and rectosigmoid cancer who underwent curative resection between January 2003 and ...
Akira Ouchi, Kozo Kataoka, Eiji Shinto, Takashi Akiyoshi, Takefumi Yoshida, Yasuyuki Takamizawa, Yukihide Kanemitsu, Hirotoshi Kobayashi, Hideki Ueno, on behalf of the Lymph Nodes Committee of JSCCR   +9 more
wiley   +1 more source

Inflammatory Signatures Beyond Th1/Th2 Endotypes Provide Insights Into Postoperative Recurrence in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) represents a spectrum of inflammatory endotypes, driven by distinct T helper (Th) immune responses. The high rate of recurrent disease despite appropriate medical and surgical interventions highlights the need for improved characterization beyond the traditional type 2 and non‐type 2 phenotypes to better
Liyona Kampel, Narin N. Carmel, Shaun Edalati, Hen Chaushu, Forsan Jahshan, Yaniv Hadi, Timur Pestrikov, Leonor Leider Trejo, Nidal Muhanna, Avraham Abergel   +9 more
wiley   +1 more source

Soluble ST2 correlates with some indicators of right ventricular function in hypertensive heart failure [PDF]

, 2017
Dike B Ojji,1,2 Sandrine Lecour,2 Olusoji M Adeyemi,3 Karen Sliwa2,4 1Cardiology Unit, Department of Medicine, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria; 2Department of Medicine, Faculty of Health Sciences, Hatter Institute for ...
Lecour S, Ojji DB, Adeyemi OM, Sliwa K
core  

IL-33 increases ST2+ Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner

OncoImmunology, 2019
Regulatory T cells (Tregs) facilitate primary and metastatic tumour growth through the suppression of anti-tumour immunity. Emerging evidence suggests a distinct role for Tregs in mediating tissue repair and barrier integrity in the lungs by IL-33 ...
E.C. Halvorsen, S.E. Franks, B.J. Wadsworth, B.T. Harbourne, R.A. Cederberg, C.A. Steer, I. Martinez-Gonzalez, J. Calder, W.W. Lockwood, K.L. Bennewith   +9 more
doaj   +1 more source

The Role of ST2 Receptor in the Regulation of Brucella abortus Oral Infection

Pathogens, 2020
The ST2 receptor plays an important role in the gut such as permeability regulation, epithelium regeneration, and promoting intestinal immune modulation. Here, we studied the role of ST2 receptor in a murine model of oral infection with Brucella abortus,
Raiany Santos, Priscila C. Campos, Marcella Rungue, Victor Rocha, David Santos, Viviani Mendes, Fabio V. Marinho, Flaviano Martins, Mayra F. Ricci, Diego C. dos Reis, Geovanni D. Cassali, José Carlos Alves-Filho, Angelica T. Vieira, Sergio C. Oliveira   +13 more
doaj   +1 more source

The IL-33/ST2 axis affects tumor growth by regulating mitophagy in macrophages and reprogramming their polarization

Cancer Biology & Medicine, 2021
Objective: Macrophages are a major component of the tumor microenvironment. M1 macrophages secrete pro-inflammatory factors that inhibit tumor growth and development, whereas tumor-associated macrophages (TAMs) mainly exhibit an M2 phenotype.
Huadan Xu, Dong Li, Jiaoyan Ma, Yuanxin Zhao, Long Xu, Rui Tian, Yanan Liu, Liankun Sun, Jing Su   +8 more
doaj   +1 more source