Results 71 to 80 of about 22,553 (226)

ST2 and regulatory T cells in the colorectal adenoma/carcinoma microenvironment: implications for diseases progression and prognosis

Scientific Reports, 2020
ST2 (also known as IL1RL1) is the critical functional receptor for interleukin (IL)-33 in stimulating regulatory T cell (Treg) expansion and function in physiological and pathological conditions.
Guanglin Cui, Aping Yuan, Zhenfeng Li, Rasmus Goll, Jon Florholmen   +4 more
doaj   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Day‐30 IL1RL1, CXCL9 and REG3α are prognostic for survival after mismatched unrelated donor transplantation

British Journal of Haematology, EarlyView.
Summary While plasma‐derived proteins have emerged as potential biomarkers for prognosis after haematopoietic stem cell transplantation (HSCT), there are insufficient data assessing if established proteins interleukin 1 receptor‐like 1 (IL1RL1), chemokine ligand 9 (CXCL9) and regenerating islet‐derived 3‐α (REG3α) retain their utility in the mismatched
Trent Wang, Anna C. Ferreira, Nasheed M. Hossain, Denggang Fu, Elizabeth G. Hill, Antonio M. Jimenez Jimenez, Cara Benjamin, Krishna V. Komanduri, Sophie Paczesny   +8 more
wiley   +1 more source

Cardiotoxicity of BRAF/MEK inhibitors

British Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe, Valerie Lohner, Kevin Terre, Thomas Riffelmacher, Roman Pfister   +4 more
wiley   +1 more source

Technology matters: AI‐driven tools in children's mental healthcare: perspectives from young people and parents

Child and Adolescent Mental Health, EarlyView.
Artificial intelligence may be able to improve the efficiency, accuracy and predictiveness of mental health assessments, and public perspectives are crucial to ensuring these tools are implemented with fairness and accountability. We developed an artificial intelligence‐driven tool to automatically analyse parents' speech data, which if successful ...
Zoë Firth, Christine Aicardi, Stephen Oram, Nicholas Cummins, Alice Wickersham, Helen L. Fisher, Johnny Downs   +6 more
wiley   +1 more source

Technology Matters: Ambient voice technology in mental health and neurodevelopmental settings – considerations for responsible implementation and evidence gaps

Child and Adolescent Mental Health, EarlyView.
Documentation comprises a large proportion of Child and Adolescent Mental Health Service (CAMHS) clinicians/practitioners' work burden and is often completed outside contracted working hours, either requiring overtime pay and/or contributing to burnout.
Judith Dineley, Noah Stanton, Aadam Aziz, Matteo Catanzano, Hissah Al Abdulsalam, Huajie Jin, Nicholas Cummins, Salim Jakhra, Solomon Wong, Johnny Downs   +9 more
wiley   +1 more source

Families' and therapists' experience of a telehealth programme for children and adolescents with cerebral palsy during the COVID‐19 pandemic

Developmental Medicine &Child Neurology, EarlyView.
Experiences of a individualized telehealth home programme. Abstract Aim To understand how families and therapists perceived their participation in an individualized home telehealth programme implemented for children and adolescents with cerebral palsy (CP) during the COVID‐19 pandemic in Brazil.
Rachel Oliveira, Marisa Mancini, Priscilla Figueiredo, Katia Bueno, Andrew M. Gordon, Marina Brandão   +5 more
wiley   +1 more source

Development of Biomarkers and Prognosis Model of Mortality Risk in Patients with COVID-19

Journal of Inflammation Research
Zhishuo Zhang,1,* Lujia Tang,1,* Yiran Guo,1 Xin Guo,2 Zhiying Pan,2 Xiaojing Ji,1,* Chengjin Gao1,* 1Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; 2School of ...
Zhang Z, Tang L, Guo Y, Guo X, Pan Z, Ji X, Gao C   +6 more
doaj  

The Children's Eating and Drinking Activity Scale: Interrater reliability, concurrent validity, and responsiveness

Developmental Medicine &Child Neurology, EarlyView.
This paper evaluated the interrater reliability, concurrent validity and responsiveness of the Children's Eating and Drinking Activity Scale ‐ a measure of functional outcome for children with paediatric feeding disorder. Abstract Aim To assess the interrater reliability, concurrent validity, and responsiveness of the Children's Eating and Drinking ...
Ericka Joinelle Mantaring, Sheung Yu Sylfiana Wong, Michelle McInerney, Vicky Thorpe, Alexandra Stewart   +4 more
wiley   +1 more source

ST2/IL-33 axis blockade inhibits regulatory T cell cytotoxicity towards CD8 T cells in the leukemic niche

Nature Communications
Acute myeloid leukemia (AML) patients present with CD8 exhaustion signatures, and pharmacologic inhibition of checkpoints can have therapeutic benefit. The alarmin IL-33 and its receptor STimulation-2 (ST2) promote activation of tissue-regulatory T cells
Hua Jiang, Denggang Fu, Santhosh Kumar Pasupuleti, Baskar Ramdas, Alan Long, Abdulraouf M. Ramadan, Jinfeng Yang, Ramesh Kumar, Jessica H. Hartman, B. Jacob Kendrick, Ed Simpson, Hongyu Gao, Yunlong Liu, Drew Moore, Suganya Subramanian, Stefano Berto, Anilkumar Gopalakrishnapillai, Sonali P. Barwe, Hongfen Guo, Nai-Kong V. Cheung, Reuben Kapur, Sophie Paczesny   +21 more
doaj   +1 more source