Results 71 to 80 of about 34,767 (273)

Clinical and prognostic significance of biomarker ratios in patients with heart failure and concomitant atrial fibrillation and diabetes mellitus

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Heart failure (HF) in combination with atrial fibrillation (AF) and diabetes mellitus (DM) significantly worsens the prognosis of patients, increasing the risk of rehospitali­zations and mortality.
N.M. Kulaiets, V.M. Kulaiets
doaj   +1 more source

An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice

Brazilian Journal of Medical and Biological Research, 2013
Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized ...
D.A.C. Magro, M.S.N. Hohmann, S.S. Mizokami, T.M. Cunha, J.C. Alves-Filho, R. Casagrande, S.H. Ferreira, F.Y. Liew, F.Q. Cunha, W.A. Verri Jr   +9 more
doaj   +1 more source

A novel interleukin 33/ST2 signaling regulates inflammatory response in human corneal epithelium. [PDF]

PLoS ONE, 2013
Interleukin (IL) 33, a member of IL-1 cytokine family, is well known to promote Th2 type immune responses by signaling through its receptor ST2. However, it is not clear whether ST2 is expressed by mucosal epithelium, and how it responds to IL-33 to ...
Jing Lin, Lili Zhang, Guiqiu Zhao, Zhitao Su, Ruzhi Deng, Stephen C Pflugfelder, De-Quan Li   +6 more
doaj   +1 more source

The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice. [PDF]

, 2015
Colorectal cancer (CRC) develops through a multistep process and is modulated by inflammation. However, the inflammatory pathways that support intestinal tumors at different stages remain incompletely understood.
Krebs, Philippe, Bruemmendorf, Thomas, Ruzzante, Giulia, Mager, Lukas F., Joller, Stefanie, Thiesler, Thore, Lugli, Alessandro, Mertz, Kirsten D, Moch, Holger, Mager, Lukas F, Brümmendorf, Thomas, Genitsch Gratwohl, Vera, Kölzer, Viktor H., Koelzer, Viktor H., Zlobec, Inti, Mertz, Kirsten D., Murdoch, Jenna R., Koelzer, Viktor H; https://orcid.org/, Cathomas, Gieri, Wasmer, Marie-Hélène, Murdoch, Jenna R, Junt, Tobias, Genitsch, Vera, Weber, Achim, Mager, Lukas, Krebs P, Mager LF, Moch, Holger; https://orcid.org/, Mertz KD, Junt T, Genitsch V, Murdoch JR, Joller S, Weber, Achim; https://orcid.org/, Thiesler T, Moch H, Lugli A, Kölzer, Viktor H.; https://orcid.org/, Zlobec I, Cathomas G, Koelzer VH, Wasmer MH, Brümmendorf T, Weber A, Ruzzante G   +44 more
core   +2 more sources

Variations in trajectories of emotional and behavioural symptoms in children and young people with pre‐existing mental health and neurodevelopmental conditions before and during the COVID‐19 pandemic: A nested data linkage clinical cohort study

JCPP Advances, EarlyView.
Abstract Background Children and young people with pre‐existing mental health and neurodevelopmental conditions may have experienced heterogeneous mental health impacts during the COVID‐19 pandemic, but what facts may explain these variations are still unclear. We aimed to examine variations in the longitudinal trajectories of emotional and behavioural
Brian C. F. Ching, Alice Wickersham, Dominic Stringer, Sarjhana Ragunathan Brindha, Craig Colling, Ruby Morton, Valeria Parlatini, Johnny Downs, Emily Simonoff   +8 more
wiley   +1 more source

Elevated Levels of Soluble ST2 were Associated with Rheumatoid Arthritis Disease Activity and Ameliorated Inflammation in Synovial Fibroblasts

Chinese Medical Journal, 2018
Background: Much evidence has demonstrated that interleukin (IL)-33 plays an important role in rheumatoid arthritis (RA). However, there have been limited studies about soluble ST2, a receptor for IL-33, in RA.
Lian-Jie Shi, Chen Liu, Jian-Hong Li, Xiao-Yun Zhu, Ying-Ni Li, Jiang-Tao Li   +5 more
doaj   +1 more source

Interleukin‐37 Enhances Liver NK Cell Cytotoxicity and Improves Recurrence‐Free Survival in Hepatocellular Carcinoma Patients

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Introduction Hepatocellular carcinoma (HCC) remains a major cause of cancer‐related mortality worldwide, and postoperative recurrence continues to limit long‐term survival. Liver‐resident natural killer (NK) cells are key effectors of antitumor immunity in the hepatic microenvironment. Interleukin‐37 (IL‐37), an anti‐inflammatory cytokine, has
Yuki Imaoka, Masahiro Ohira, Yuka Tanaka, Toshihiro Nakayama, Miho Akabane, Shinichiro Yokota, Sheri M. Krams, Olivia M. Martinez, Carlos O. Esquivel, Kazunari Sasaki, Hideki Ohdan   +10 more
wiley   +1 more source

ST2/IL-33 signaling in cardiac fibrosis

, 2019
Cardiac fibrosis is a significant global health problem associated with nearly all forms of heart disease. In the heart interstitial fibrosis may be reparative, replacing areas damaged by myocyte loss after acute infarction, or compensative, responding ...
Luigi Frati, Lorenza Tacchini, Elena Vianello, Massimiliano Marco Corsi Romanelli, Elena Dozio   +4 more
core   +1 more source

Role of the IL-33/ST2 pathway in renal allograft rejection

, 2021
The interleukin-33 (IL-33)/suppression of tumorigenicity 2 (ST2) pathway modulates immune response and inflammation, associated with allograft dysfunction and rejection.
Yu, Mi-Yeon, Han, Sang-Woong, Kim, Yon Su, Song, Eun Young, Kim, Dong Ki, Moon, Kyung Chul, Moon, Jong Joo, Yang, Seung Hee, Ha, Jongwon, Lee, Hajeong, Kwon, Soie, Kim, Yong-Chul, Kim, Gheun-Ho, Yong-Chul Kim, Mi-Yeon Yu, Eun Young Song, Gheun-Ho Kim, Jong Joo Moon, Yon Su Kim, Seung Hee Yang, Jongwon Ha, Sang-Woong Han, Kyung Chul Moon, Soie Kwon, Hajeong Lee, Dong Ki Kim   +25 more
core   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source