Results 81 to 90 of about 4,650,966 (303)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Effect of Mg and Ca on the Stability of the MRI Contrast Agent Gd–DTPA in Seawater
Frontiers in Marine Science, 2018 Gadolinium diethylenetriaminepentaacetic acid (Gd–DTPA) is widely applied as a contrast enhancer in medical MRI. As Gd–DTPA is only minimally captured in wastewater treatment plants (WTPs) or degraded by UV light and other oxidative processes ...
Johan Schijf, Isabel J. Christy
doaj +1 more source
Developmental stability in constant and fluctuating temperatures
Heredity, 1960 Uploaded by Plazi for TaxoDros. We do not have abstracts.
openaire +1 more source
Constant-drive dynamics of the spiking network.
(A) Four dynamical regimes depending on the external drive: asynchronous irregular state, sparse synchrony, full synchrony, multiple spikes (left to right, N = 10, 000). Top: population rate rN, middle: raster plot showing spikes of 30 example units, and
Richard Kempter (588141) +3 more
core +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Stability of hypersurfaces with constant mean curvature
Mathematische Zeitschrift, 1984 Let \(x:{\text M}^{n}\rightarrow\,{\text R}^{n+1}\) be an immersion of an orientable, n-dimensional manifold \({\text M}^{n}\) into the euclidean space \({\text R}^{n+1}\). The condition that x has nonzero constant mean curvature H = H 0 is known to be equivalent to the fact that xis a critical point of a variational problem.
Barbosa, Joao, do, Carmo Manfredo
openaire +2 more sources
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
The link between relative stability constant of DNA- and BSA-chromenopyrimidine complexes and cytotoxicity towards human breast cancer cells (MCF-7). [PDF]
RSC Adv, 2023 Zamisa SJ +5 more
europepmc +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source