Results 101 to 110 of about 478,710 (331)

Monitoring of dynamin during the Toxoplasma gondii cell cycle [PDF]

, 2016
The obligate intracellular protozoan parasite Toxoplasma gondii actively invades virtually all warm-blooded nucleated cells. This process results in a non-fusogenic vacuole, inside which the parasites replicate continuously until egress signaling is ...
Attias, Marcia, Caldas, Lucio Ayres, de Souza, Wanderley, Lemgruber Soares, Leandro, Seabra, Sergio Henrique   +4 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The application of different staining methods in the morphological observation of non-decalcified bone tissue sections containing implants [PDF]

精准医学杂志
Objective To investigate the application and advantages of different staining methods in the morphological observation of non-decalcified bone tissue sections containing implants.
XU Qian, ZHANG Fan, ZHANG Liguo
doaj   +1 more source

Pharmacological Blockade of the Calcium Plateau Provides Neuroprotection Following Organophosphate Paraoxon Induced Status Epilepticus in Rats [PDF]

, 2016
Organophosphate (OP) compounds which include nerve agents and pesticides are considered chemical threat agents. Currently approved antidotes are crucial in limiting OP mediated acute mortality.
Ajdacic-Gross, Bajgar, Baker, Barkus, Battaglia, Bengtson, Beverly A. Huang, Campbell, Chemical Hazards Emergency Medical Management, de Araujo Furtado, DeLorenzo, DeLorenzo, Deshpande, Deshpande, Deshpande, Deshpande, Deshpande, Faure, Filbert, Grynkiewicz, Haley, Helmstaedter, Hood, Konradsen, Kristin F. Phillips, Laxmikant S. Deshpande, Li, Li, Loubinoux, Nagarkatti, Neligan, Niebauer, Peng, Phillips, Raghupathi, Raza, Robert E. Blair, Robert J. DeLorenzo, Rod, Savage, Sellstrom, Than, Truitt, Tuovinen   +43 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Enhanced Histochemical Detection of Iron in Paraffin Sections of Mouse Central Nervous System Tissue

ASN Neuro, 2016
Histochemical methods of detecting iron in the rodent brain result mainly in the labeling of oligodendrocytes, but as all cells utilize iron, this observation suggests that much of the iron in the central nervous system goes undetected.
Scott A. Sands, Regis Leung-Toung, Yingsheng Wang, John Connelly, Steven M. LeVine   +4 more
doaj   +1 more source

Novel components of the Toxoplasma inner membrane complex revealed by BioID. [PDF]

, 2015
UNLABELLED:The inner membrane complex (IMC) of Toxoplasma gondii is a peripheral membrane system that is composed of flattened alveolar sacs that underlie the plasma membrane, coupled to a supporting cytoskeletal network. The IMC plays important roles in
Bell, Hannah N, Bentolila, Laurent A, Bradley, Peter J, Chen, Allan L, Huang, Amy S, Kim, Elliot W, Moon, Andy S, Rashoff, Andrew Q, Toh, Justin Y, Van, Christina, Vashisht, Ajay A, Wohlschlegel, James A   +11 more
core   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Chondrosarcoma evaluation using hematein-based x-ray staining and high-resolution 3D micro-CT: a feasibility study

European Radiology Experimental
Background Chondrosarcomas are rare malignant bone tumors diagnosed by analyzing radiological images and histology of tissue biopsies and evaluating features such as matrix calcification, cortical destruction, trabecular penetration, and tumor cell ...
Alexandra S. Gersing, Melanie A. Kimm, Christine Bollwein, Patrick Ilg, Carolin Mogler, Felix G. Gassert, Georg C. Feuerriegel, Carolin Knebel, Klaus Woertler, Daniela Pfeiffer, Madleen Busse, Franz Pfeiffer   +11 more
doaj   +1 more source