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Learning from stargazin: the mouse, the phenotype and the unexpected
Current Opinion in Neurobiology, 2006The stargazin gene (also referred to as Cacng2) has been identified by forward genetics in a spontaneous mouse mutant with ataxic gait, upward head-elevating movements (hence the name stargazer for the mouse) and episodes of spike-wave discharges. Stargazin is related to the gamma-1 subunit of skeletal muscle voltage-dependent calcium channel (VDCC ...
Osten, P., Stern-Bach, Y.
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Brain Research, 2006
Stargazin mutation results in absence epilepsy and cerebellar ataxia in stargazer (stg) mice. We have previously discovered defects of AMPA receptor function, failure of BDNF expression and immature morphology specifically in the cerebellar cortex of stg mice.
Hongdi, Meng +3 more
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Stargazin mutation results in absence epilepsy and cerebellar ataxia in stargazer (stg) mice. We have previously discovered defects of AMPA receptor function, failure of BDNF expression and immature morphology specifically in the cerebellar cortex of stg mice.
Hongdi, Meng +3 more
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Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Nature, 2000Stargazer, an ataxic and epileptic mutant mouse, lacks functional AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate) receptors on cerebellar granule cells. Stargazin, the mutated protein, interacts with both AMPA receptor subunits and synaptic PDZ proteins, such as PSD-95.
L, Chen +7 more
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Dynamic Interaction of Stargazin-like TARPs with Cycling AMPA Receptors at Synapses
Science, 2004Activity-dependent plasticity in the brain arises in part from changes in the number of synaptic AMPA receptors. Synaptic trafficking of AMPA receptors is controlled by stargazin and homologous transmembrane AMPA receptor regulatory proteins (TARPs). We found that TARPs were stable at the plasma membrane, whereas AMPA receptors were internalized in a ...
Susumu, Tomita +3 more
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Stargazin as a regulator of neuronal excitability
2023Neuronal excitability refers to the ability of neurons to generate a change in membrane voltage in response to stimuli, and it is a fundamental characteristic of neurons at the basis of neuronal communication. The M-current is a low-threshold potassium current that determines neuronal excitability and contributes to dampening repetitive neuronal firing.
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Glutamate Receptor Clusters: Narp, EphB2 Receptor, Stargazin
2009M.C. Chang, R.W. Cho, P.F. Worley
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