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STAT3: a multifaceted oncoprotein
Growth Factors, 2018Signal transducer and activator of transcription (STAT) 3 is a key signalling protein engaged by a multitude of growth factors and cytokines to elicit diverse biological outcomes including cellular growth, differentiation, and survival. The complete loss of STAT3 is not compatible with life and even partial loss of function mutations lead to ...
Aleks C. Guanizo +3 more
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The FASEB Journal, 2021
Hepatic fibrosis is a wound healing response that results in excessive extracellular matrix (ECM) accumulation in response to chronic hepatic injury.
Min Tang +8 more
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Hepatic fibrosis is a wound healing response that results in excessive extracellular matrix (ECM) accumulation in response to chronic hepatic injury.
Min Tang +8 more
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Gut, 2019
Objective Cancer-associated fibroblasts (CAFs) influence the tumour microenvironment and tumour growth. However, the role of CAFs in colorectal cancer (CRC) development is incompletely understood.
Christina Heichler +24 more
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Objective Cancer-associated fibroblasts (CAFs) influence the tumour microenvironment and tumour growth. However, the role of CAFs in colorectal cancer (CRC) development is incompletely understood.
Christina Heichler +24 more
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Nature Reviews Cancer, 2018
D’Amico et al. show that, in the presence of oncogenic RAS mutations, STAT3 acts as a tumour modifier by regulating the epithelial differentiation of pancreatic and lung cancer cells via p63.
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D’Amico et al. show that, in the presence of oncogenic RAS mutations, STAT3 acts as a tumour modifier by regulating the epithelial differentiation of pancreatic and lung cancer cells via p63.
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Nature Reviews Cancer, 2018
Priego et al. show that a subpopulation of reactive astrocytes expressing signal transducer and activator of transcription 3 (STAT3) is crucial for the development of brain metastases and report positive initial clinical data that inhibiting STAT3 can reduce metastasis.
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Priego et al. show that a subpopulation of reactive astrocytes expressing signal transducer and activator of transcription 3 (STAT3) is crucial for the development of brain metastases and report positive initial clinical data that inhibiting STAT3 can reduce metastasis.
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2003
STAT3 is perhaps the STAT family member whose physiological functions are less well understood. It was initially identified as Acute Phase Response Factor (APRF), a DNA-binding activity appearing in IL-6-treated hepatocytes and interacting with an Acute Phase Response Element (APRE) on the promoter of several IL-6-responsive genes (1).
POLI, Valeria, ALONZI T.
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STAT3 is perhaps the STAT family member whose physiological functions are less well understood. It was initially identified as Acute Phase Response Factor (APRF), a DNA-binding activity appearing in IL-6-treated hepatocytes and interacting with an Acute Phase Response Element (APRE) on the promoter of several IL-6-responsive genes (1).
POLI, Valeria, ALONZI T.
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Science's STKE, 2003
Signal transducer and activator of transcription 3 (STAT3) is widely expressed and activated by various growth-regulating signals, as well as diverse cytokines, that activate gp130 signaling receptors. Hence, STAT3 is critical for embryonic development and stem cell biology, as well as inflammation, growth regulation, and multiple immune ...
D. S. Aaronson, C. M. Horvath
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Signal transducer and activator of transcription 3 (STAT3) is widely expressed and activated by various growth-regulating signals, as well as diverse cytokines, that activate gp130 signaling receptors. Hence, STAT3 is critical for embryonic development and stem cell biology, as well as inflammation, growth regulation, and multiple immune ...
D. S. Aaronson, C. M. Horvath
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LncRNA STAT3-AS regulates endometrial receptivity via the STAT3 signaling pathway
TheriogenologyEndometrial receptivity is critical for the successful establishment of pregnancy in ruminants. Interferon tau (IFNT) plays a key role in promoting embryo attachment by activating the Janus kinase/signal transducer and activator of transcription pathway, which induces the expression of a series of interferon-stimulated genes (ISGs).
Yanni, Jia +11 more
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Science, 2009
A protein that has a nuclear function as a transcription factor also functions to support respiration in the mitochondria.
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A protein that has a nuclear function as a transcription factor also functions to support respiration in the mitochondria.
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Journal of Cellular Biochemistry, 2018
Human cancers, including hepatocellular carcinoma (HCC), are characterized by a high degree of drug resistance in chemotherapy. However, the underlying molecular mechanism remains unknown.
Z. Yin +6 more
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Human cancers, including hepatocellular carcinoma (HCC), are characterized by a high degree of drug resistance in chemotherapy. However, the underlying molecular mechanism remains unknown.
Z. Yin +6 more
semanticscholar +1 more source