Results 291 to 300 of about 196,678 (325)

Identification and characterization of a TGF-β-independent SMAD4-NFATc1-STAT3 regulatory axis. [PDF]

J Mol Cell Biol
Ouyang W, Hao J, Niu Q, Douglass EF, Beusch CM, Gordon DE, Hall M, Moffitt RA, Du Y, Mo X.   +9 more
europepmc   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

IGF2BP3-STAT3-METTL3 axis promotes malignant progression in hepatocellular carcinoma (HCC). [PDF]

Hum Genomics
Xu Y, Cao Y, Yang J, Yu X, Yang L, Xie Y, Zhao J, Zhang Y.   +7 more
europepmc   +1 more source

Molecular crosstalk via exosomes in lung cancer progression

Interdisciplinary Medicine, EarlyView.
“Molecular and theranostics roles of exosomes in Lung Cancer.” Abstract Exosomes play a critical role in lung cancer metastasis, facilitating tumor progression through intercellular communication between cancer cells and the tumor microenvironment. These nanosized extracellular vesicles carry bioactive molecules such as proteins, nucleic acids, and ...
Rajib Dhar, Vinoth Kumarasamy, Brian G. Oliver, Vetriselvan Subramaniyan   +3 more
wiley   +1 more source

Rho-related GTP-binding protein RhoE (RND3) regulates multiple myeloma bone disease. [PDF]

Cancer Cell Int
Gao Q, Tang W, Mi Z, He S, Yang H, Wang F, Huang J, Zhang Y, Wen J, Li L, Luo H, Liu X, Zhai X, Zhao X, Zhang L, Niu T, Zheng Y.   +16 more
europepmc   +1 more source

HDAC6 deficiency exacerbates atherosclerosis via STAT3-K685 acetylation-mediated CD36/SR-A upregulation in macrophages. [PDF]

Cell Death Dis
Wang W, Jiang Y, Pan X, Chen D, Yang H, Pan W, Pan M, Wang B.   +7 more
europepmc   +1 more source

Regulation of apoptosis, ferroptosis, and pyroptosis mediated by acetylation. [PDF]

Cell Death Discov
Lu W, Deng Y, Liu M, Hu Y, Yang K, Wang B, Li Y, Wang G, Ma L, Liu J, Xie Y, Li Q, Liu A, Zhang X, Xie P.   +14 more
europepmc   +1 more source

RPL18 promotes melanoma progression and drug resistance via BTF3/STAT3-dependent mechanisms and immune modulation. [PDF]

iScience
Zuo C, Hu C, Jiang X, Bu X.
europepmc   +1 more source

Decoding the metastatic nexus: how chronic stress reprograms neuroendocrine-metabolic-microbiome circuits to fuel tumor metastasis. [PDF]

Am J Cancer Res
Wang Y, Sun W, Li H, Xu F, Cui W.
europepmc   +1 more source