Results 151 to 160 of about 22,335 (252)

Metabolic dysfunction-associated steatotic liver disease: pathogenesis and novel treatment options. [PDF]

Mol Biomed
Ren R, Liang X, Wei X.
europepmc   +1 more source

Correction to “Chinese Registry on Transjugular Intrahepatic Portosystemic Shunts (CN‐TIPS): Protocol for a Registry‐Based, Prospective Prognostic Study”

Portal Hypertension &Cirrhosis, EarlyView.
wiley   +1 more source

Efficacy of Luseogliflozin Added to Semaglutide in Patients With Metabolic Dysfunction‐Associated Steatohepatitis and Type 2 Diabetes Mellitus: A Randomised, Open‐Label Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Type 2 diabetes drives the progression of metabolic dysfunction‐associated steatohepatitis (MASH). We evaluated whether antidiabetic therapy, specifically adding sodium–glucose cotransporter 2 (SGLT2) inhibitor to a glucagon‐like peptide‐1 receptor agonist (GLP‐1RA), improves liver histology in adults with biopsy‐proven MASH and type 2 ...
Teruki Miyake, Osamu Yoshida, Shinya Furukawa, Masashi Hirooka, Masanori Abe, Yoshio Tokumoto, Ayumi Kanamoto, Takao Watanabe, Ryo Yano, Yuki Okazaki, Atsushi Yukimoto, Yoshiko Nakamura, Eiji Takeshita, Teru Kumagi, Yoichi Hiasa   +14 more
wiley   +1 more source

Editorial: Hot topics in diabetes and steatotic liver disease. [PDF]

Front Clin Diabetes Healthc
Stoica RA.
europepmc   +1 more source

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses

The FEBS Journal, EarlyView.
Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki, Timothy D. Niepokny, Tina Khalilzadehsabet, Elizabeth Dumais, Nicolas Flamand, Vincenzo Di Marzo, Eric M. Mintz, Cristoforo Silvestri   +7 more
wiley   +1 more source

Association of food insecurity with metabolic dysfunction-associated steatotic liver disease by sex and race/ethnicity. [PDF]

Eur J Nutr
Tao MH, Lin CH, Liu J, Chai W, Trudeau S, Gonzalez HC, Lu M, Gordon SC.   +7 more
europepmc   +1 more source

Bringing Gene Therapy Into Real World Clinical Practice

Haemophilia, EarlyView.
ABSTRACT Introduction Adeno‐associated virus (AAV)‐based gene therapy for haemophilia has shifted therapeutic paradigms by enabling hepatic gene transfer, restoring endogenous clotting factor expression, and reducing reliance on conventional prophylactic treatments. Two products, valoctocogene roxaparvovec (haemophilia A) and etranacogene dezaparvovec (
Wolfgang Miesbach, Pratima Chowdary, Margareth C. Ozelo   +2 more
wiley   +1 more source

The metabolic vulnerability index predicts outcomes in patients with metabolic dysfunction associated steatotic liver disease. [PDF]

Nat Commun
Siddiqui MS, Van Natta ML, Connelly MA, Clark J, Neuschwander-Tetri BA, Diehl AM, Dasarathy S, Loomba R, Chalasani N, Kowdley KV, Hameed B, Wilson LA, Yates KP, Belt P, Kleiner DE, Behling C, Tonascia J, Sanyal AJ.   +17 more
europepmc   +1 more source

Embracing Change: From Nonalcoholic Fatty Liver Disease to Metabolic Dysfunction-Associated Steatotic Liver Disease Under the Steatotic Liver Disease Umbrella

Clinical Gastroenterology and Hepatology
Mazen Noureddin, Lai Wei, Laurent Castera, Emmanuel A. Tsochatzis   +3 more
openaire   +3 more sources

The gut-liver axis in progressive steatotic liver disease

The gut-liver axis regulates metabolic homeostasis, with bile acids (BAs) serving as key signalling molecules. BA dysregulation is implicated in metabolic dysfunction-associated steatotic liver disease (MASLD)and metabolic dysfunction- and alcohol-associated liver disease (MetALD), yet consistent identification of BA markers and their mechanistic roles
Louca, Panayiotis, Pericàs, Juan M.||, Lin, Yu, Kouraki, Afroditi, Estévez-Vázquez, Olga, Martínez-Gómez, María, Cusidó, M. Serra, Simpson, Joanna P., Cubero, Francisco Javier, Homer, Natalie Z.M., Valdes, Ana M., Menni, Cristina   +11 more
openaire   +1 more source