Results 31 to 40 of about 22,335 (252)

S-nitroso-N-acetylcysteine ameliorates ischemia-reperfusion injury in the steatotic liver

Clinics, 2010
BACKGROUND: Steatosis is currently the most common chronic liver disease and it can aggravate ischemia-reperfusion (IR) lesions. We hypothesized that S-nitroso-N-acetylcysteine (SNAC), an NO donor component, can ameliorate cell damage from IR injury.
Wellington Andraus, Gabriela Freitas Pereira de Souza, Marcelo Ganzarolli de Oliveira, Luciana B. P. Haddad, Ana Maria M. Coelho, Flavio Henrique Galvão, Regina Maria Cubero Leitão, Luiz Augusto Carneiro D'Albuquerque, Marcel Cerqueira Cesar Machado   +8 more
doaj   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Viability assessment and transplantation of fatty liver grafts using end‐ischemic normothermic machine perfusion

Liver Transplantation, EarlyView., 2022
Abstract End‐ischemic viability testing by normothermic machine perfusion (NMP) represents an effective strategy to recover liver grafts having initially been discarded for liver transplantation (LT). However, its results in the setting of significant (≥30%) macrovesicular steatosis (MaS) have not been specifically assessed.
Damiano Patrono, Riccardo De Carlis, Alessandro Gambella, Francesca Farnesi, Alice Podestà, Andrea Lauterio, Francesco Tandoi, Luciano De Carlis, Renato Romagnoli   +8 more
wiley   +1 more source

CircDock6 drives metabolic dysfunction–associated steatotic liver disease progression in mice and mouse hepatocytes via mmu-let-7g-5p/insulin-like growth factor 1 receptor regulation

Journal of International Medical Research
Objective Circular RNAs belong to a category of noncoding RNAs that feature a unique continuous, covalently bonded ring configuration. Recent research indicates that circular RNAs are essential for the development of metabolic dysfunction–associated ...
Hongpeng Lu, Xiaoyun Ding, Peifei Li
doaj   +1 more source

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

Advanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu, Zun Fan, Zhen Liu, Lei Qin, Xin Zhao   +4 more
wiley   +1 more source

MetALD: Clinical aspects, pathophysiology and treatmentKeypoints

JHEP Reports
Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) and alcohol-related liver disease (ALD) are the most prevalent causes of chronic liver disease worldwide. Both conditions have many pathophysiological mechanisms in common, such as
Jordi Gratacós-Ginès, Silvia Ariño, Pau Sancho-Bru, Ramon Bataller, Elisa Pose   +4 more
doaj   +1 more source

Pancreatic Atrophy: A Narrative Review and Surgical Interpretation

Annals of Gastroenterological Surgery, EarlyView.
Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino, Ken‐ichi Okada, Yohei Masugi, Eisuke Iwasaki, Masaki Mori   +4 more
wiley   +1 more source

Epicardial and liver fat implications in albuminuria: a retrospective study

Cardiovascular Diabetology
Background Albuminuria is considered an early and sensitive marker of kidney dysfunction, but also an independent cardiovascular risk factor. Considering the possible relationship among metabolic liver disease, cardiovascular disease and chronic kidney ...
Carolina M. Perdomo, Nerea Martin-Calvo, Ana Ezponda, Francisco J. Mendoza, Gorka Bastarrika, Nuria Garcia-Fernandez, José I. Herrero, Inmaculada Colina, Javier Escalada, Gema Frühbeck   +9 more
doaj   +1 more source

Inflammation in MASLD progression and cancerKey points:

JHEP Reports
Summary: Steatotic liver diseases include metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-associated liver disease, and metabolic dysfunction and alcohol-related liver disease (MetALD), encompassing a spectrum of metabolic liver
Yeonsoo Kim, Yunseo Park, Hyunsoo Rho, Tiantian Yao, Bin Gao, Seonghwan Hwang   +5 more
doaj   +1 more source

Very Long‐Term Outcomes of Laparoscopic Adjustable Gastric Banding in a Japanese Cohort: A Single‐Center 15‐Year Follow‐Up Study

Annals of Gastroenterological Surgery, EarlyView.
Long‐term outcomes of laparoscopic adjustable gastric banding (LAGB) in Japan were retrospectively evaluated in 28 patients with up to 15 years of follow‐up. LAGB achieved sustained long‐term weight reduction in selected patients; however, recurrence of metabolic comorbidities increased during extended follow‐up.
Yuichi Endo, Hiroomi Takayama, Wataru Miyoshino, Shun Nakamura, Yuiko Nagasawa, Masahiro Kawamura, Yoko Kawano, Takashi Masuda, Teijiro Hirashita, Yoshinori Ozeki, Takayuki Masaki, Hirotaka Shibata, Masafumi Inomata   +12 more
wiley   +1 more source