Results 41 to 50 of about 5,456,142 (288)

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

Advanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu, Zun Fan, Zhen Liu, Lei Qin, Xin Zhao   +4 more
wiley   +1 more source

The therapeutic potential of different mesenchymal stem cells and their derived exosomes in metabolic dysfunction-associated steatotic liver disease

Frontiers in Endocrinology
Metabolic dysfunction-associated steatotic liver disease is a metabolic disease with an increasing incidence. Its pathogenesis involves the interaction of multiple factors.
Dan Qin, Pingping Huang, Jialing Chen, Changjun Wu, Yuzhen Liang   +4 more
doaj   +1 more source

S-nitroso-N-acetylcysteine ameliorates ischemia-reperfusion injury in the steatotic liver

Clinics, 2010
BACKGROUND: Steatosis is currently the most common chronic liver disease and it can aggravate ischemia-reperfusion (IR) lesions. We hypothesized that S-nitroso-N-acetylcysteine (SNAC), an NO donor component, can ameliorate cell damage from IR injury.
Wellington Andraus, Gabriela Freitas Pereira de Souza, Marcelo Ganzarolli de Oliveira, Luciana B. P. Haddad, Ana Maria M. Coelho, Flavio Henrique Galvão, Regina Maria Cubero Leitão, Luiz Augusto Carneiro D'Albuquerque, Marcel Cerqueira Cesar Machado   +8 more
doaj   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

CircDock6 drives metabolic dysfunction–associated steatotic liver disease progression in mice and mouse hepatocytes via mmu-let-7g-5p/insulin-like growth factor 1 receptor regulation

Journal of International Medical Research
Objective Circular RNAs belong to a category of noncoding RNAs that feature a unique continuous, covalently bonded ring configuration. Recent research indicates that circular RNAs are essential for the development of metabolic dysfunction–associated ...
Hongpeng Lu, Xiaoyun Ding, Peifei Li
doaj   +1 more source

Autoimmune Liver Disease Associated With Celiac Disease in Childhood: A Multicenter Study

, 2008
Patients with autoimmune liver disease might have a hidden celiac disease, suggesting a rigorous check in any cryptogenic liver ...
VAJRO P, SIGENP STUDY GROUP FOR AUTOIMMUNE LIVER DISORDERS IN CELIAC DISEASE, VENTURA, ALESSANDRO, CAPRAI S, MAGGIORE G, SCIVERES M   +5 more
core   +1 more source

Comparative efficacy of GLP‐1 RA, tirzepatide and SGLT‐2 inhibitors in metabolic liver disease: A network meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić, Christina Antza, Anastasios Poutachidis, Smaro Palaska, Elvira Meni Maria Gkrinia, Andrea Katrin Faour, Yusuf Ziya Sener, Seher Sener, Rehena Sultana   +8 more
wiley   +1 more source

Conjugated bile acid-driven CD14+CD16+ monocyte infiltration promotes cholestatic liver injury by enhancing hepatocyte necroptosis

JHEP Reports
Background & Aims: Cell death and inflammation cause liver injury during cholestasis. Monocyte infiltration is crucial for the inflammatory response in tissues and organs.
Zhixian Zhu, Ziqian Xu, Xinyu Cao, Nan Zhao, Jiaxin Lei, Ling Li, Xi Li, Yan Li, Mingqiao Li, Tian Ren, Li Liu, James L. Boyer, Shi-ying Cai, Qiong Pan, Xiaoxun Zhang, Jin Chai   +15 more
doaj   +1 more source

New therapeutic options for metabolic‐associated steatotic liver disease

British Journal of Clinical Pharmacology, EarlyView.
An increasing number of patients are being diagnosed with metabolic dysfunction‐associated steatotic liver disease (MASLD). MASLD results from disturbances in hepatic lipid metabolism and is associated with an increased risk of cirrhosis and hepatocellular carcinoma and significant extrahepatic morbidity, including cardiovascular disease and ...
Tessa Straatmijer, Midas Mulder
wiley   +1 more source

Epicardial and liver fat implications in albuminuria: a retrospective study

Cardiovascular Diabetology
Background Albuminuria is considered an early and sensitive marker of kidney dysfunction, but also an independent cardiovascular risk factor. Considering the possible relationship among metabolic liver disease, cardiovascular disease and chronic kidney ...
Carolina M. Perdomo, Nerea Martin-Calvo, Ana Ezponda, Francisco J. Mendoza, Gorka Bastarrika, Nuria Garcia-Fernandez, José I. Herrero, Inmaculada Colina, Javier Escalada, Gema Frühbeck   +9 more
doaj   +1 more source