Results 101 to 110 of about 1,204,232 (364)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Probing the non-thermal physics of stellar bow shocks using radio observations [PDF]

, 2023
J. R. Martinez, S. del Palacio, V. Bosch‐Ramon   +2 more
openalex   +1 more source

Reverse Shock Revisited in Cassiopeia A with Chandra

The Astrophysical Journal
Using data from the Chandra X-ray Observatory, we revisit the reverse shock in the supernova remnant (SNR) Cassiopeia A. Based on spectroscopy of a series of annuli in the northwest (NW) and southeast (SE), we get the radial profiles of the S/Si K α line
Yin Wu, X. J. Yang
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Introduction to nuclear astrophysics

, 2009
In the first lecture of this volume, we will present the basic fundamental ideas regarding nuclear processes occurring in stars. We start from stellar observations, will then elaborate on some important quantum-mechanical phenomena governing nuclear ...
Iliadis, Christian
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Boron Abundances in Early B Dwarfs of the Galactic Open Cluster NGC 3293

The Astrophysical Journal
New boron abundances or upper limits have been determined for eight early B stars in the young Galactic open cluster NGC 3293, using UV spectra obtained by the Hubble Space Telescope Cosmic Origins Spectrograph.
Charles R. Proffitt, Harim Jin, Simone Daflon, Daniel J. Lennon, Norbert Langer, Katia Cunha, Talawanda Monroe   +6 more
doaj   +1 more source

The s Process: Nuclear Physics, Stellar Models, Observations

, 2010
Nucleosynthesis in the s process takes place in the He burning layers of low mass AGB stars and during the He and C burning phases of massive stars. The s process contributes about half of the element abundances between Cu and Bi in solar system material.
Allen, B., Aoki, W., Aoki, W., Beer, H., Beer, H., Bisterzo, S., Bisterzo, S., Borella, A., Bradley, T., Chau, L., Christlieb, N., Clayton, D., Cristallo, S., de L. Musgrove, A., Diehl, R., Dillmann, I., Dillmann, I., Dupraz, C., Edvardsson, B., F. Käppeler, F. Rau, Freytag, B., Fürst, E., Gallino, R., Goriely, S., Gratton, R., Guber, K., Herwig, F., Herwig, F., Hill, V., Jehin, E., Koning, A., Käppeler, F., Lambert, D., Langer, N., Lisowski, P., Macklin, R., Macklin, R., Macklin, R., Macklin, R., Meusel, O., Perey, F., Prantzos, N., Péquignot, D., R. Gallino, Ratzinger, U., Rau, F., S. Bisterzo, Sadakane, K., Spencer, R., Straniero, O., Suda, T., Tain, J., Thielemann, F.-K., Van Winckel, H., Wako Aoki, Ward, R., Weigert, A., Wisshak, K., Woodward, P.   +59 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source