Results 101 to 110 of about 1,100,727 (344)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Constraining Stellar Winds of Young Sun-like Stars

, 2013
As part of the project Pathways to Habitability (http://path.univie.ac.at/), we study the properties of the stellar winds of low-mass and Sun-like stars, and their influences on the atmospheres of potentially habitable planets.
Fichtinger, Bibiana, Güdel, Manuel, Johnstone, Colin P., Lüftinger, Theresa   +3 more
core   +1 more source

The Solar--Stellar Connection [PDF]

, 2004
Stars have proven to be surprisingly prolific radio sources and the added sensitivity of the Square Kilometer Array will lead to advances in many directions.
Anglada, Bower, Carkner, Chen, Chiang, Dougherty, Drake, Dreher, Felli, Furuya, Garay, Garay, Gu, Güdel, Güdel, Harper, Kai, Kaufmann, Lestrade, Lim, Lim, Lim, Lucy, Magazzú, Osten, Panagia, Reipurth, Rodríguez, S.M. White, Simon, Stine, Trigilio, van den Oord, Vernazza, White, White, White, White, White, Wood, Wood, Wright, Zirin   +42 more
core   +2 more sources

Clumped stellar winds in supergiant high‐mass X‐ray binaries: X‐ray variability and photoionization [PDF]

, 2012
The clumping of massive star winds is an established paradigm confirmed by multiple lines ofevidence and supported by stellar wind theory. The purpose of this paper is to bridge the gapbetween detailed models of inhomogeneous stellar winds in single stars
L. Oskinova, A. Feldmeier, P. Kretschmar
semanticscholar   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

A Blind Search for Magnetospheric Emissions from Planetary Companions to Nearby Solar-type Stars

, 2009
This paper reports a blind search for magnetospheric emissions from planets around nearby stars. Young stars are likely to have much stronger stellar winds than the Sun, and because planetary magnetospheric emissions are powered by stellar winds ...
Aubier, Barrow, Bastian, Berger, Blair, Cohen, E. Elkins, Gergely, Gray, Gray, Hallinan, J. Clark, Jenkins, L. A. Hennig, Lazio, Lazio, M. Szwajkowski, Marcy, P. Gudmundsen, Perryman, Rees, Rucker, S. Carmichael, Saar, Saar, Schneider, T. Joseph W. Lazio, Takeda, Wood, Wood, Yantis, Z. Mott, Zarka, Zarka   +33 more
core   +1 more source

Really focused stellar winds in X-ray binaries [PDF]

, 2012
Aims. We investigate the anisotropy of stellar winds in binaries to improve the models of accretion in high-mass X-ray binaries. Methods. We model numerically the stellar wind from a supergiant component of a binary in radial and three-dimensional ...
P. Hadrava, Jan vCechura
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Testing the Rossby Paradigm: Weakened Magnetic Braking in Early K-type Stars

The Astrophysical Journal
There is an intricate relationship between the organization of large-scale magnetic fields by a stellar dynamo and the rate of angular momentum loss due to magnetized stellar winds. An essential ingredient for the operation of a large-scale dynamo is the
Travis S. Metcalfe, Pascal Petit, Jennifer L. van Saders, Thomas R. Ayres, Derek Buzasi, Oleg Kochukhov, Keivan G. Stassun, Marc H. Pinsonneault, Ilya V. Ilyin, Klaus G. Strassmeier, Adam J. Finley, Rafael A. García, Daniel Huber, Yuxi (Lucy) Lu, Victor See   +14 more
doaj   +1 more source