Results 121 to 130 of about 3,799 (315)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Radiative Nonideal Magnetohydrodynamic Simulations of Inner Protoplanetary Disks: Temperature Structures, Asymmetric Winds, and Episodic Surface Accretion

The Astrophysical Journal
We perform 2D global magnetohydrodynamic (MHD) simulations including the full nonideal MHD effects (ohmic diffusion, Hall effect, and ambipolar diffusion) and approximate radiation transport to understand the dynamics and thermal structure of the inner ...
Shoji Mori, Xue-Ning Bai, Kengo Tomida
doaj   +1 more source

Simulations of stellar winds from X-ray bursts. Characterization of solutions and observable variables

, 2020
Yago Herrera, G. Sala, J. José
openalex   +2 more sources

3-D Dynamics of Interactions between Stellar Winds and the Interstellar Medium as Seen by AKARI and Spitzer [PDF]

, 2009
Toshiya Ueta, Hideyuki Izumiura, I. Yamamura, R. E. Stencel, Y. Nakada, M. Matsuura, Yoshifusa Ita, Toshihiko Tanabé, H. Fukushi, Noriyuki Matsunaga, Hiroyuki Mito, A. K. Speck   +11 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The Optically Thick Rotating Magnetic Wind from a Massive White Dwarf Merger Product. II. Axisymmetric Magnetohydrodynamic Simulations

The Astrophysical Journal
We numerically construct a series of axisymmetric rotating magnetic wind solutions, aiming at exploring the observation properties of massive white dwarf (WD) merger remnants with a strong magnetic field, a fast spin, and an intense mass loss, as ...
Yici Zhong, Kazumi Kashiyama, Shinsuke Takasao, Toshikazu Shigeyama, Kotaro Fujisawa   +4 more
doaj   +1 more source

Measurements of Low Temperature Rate Coefficients for the Reaction of CH with CH₂O and Application to Dark Cloud and AGB Stellar Wind Models [PDF]

, 2019
Niclas A. West, Tom J. Millar, Marie Van de Sande, Edward Rutter, Mark A. Blitz, Leen Decin, Dwayne E. Heard   +6 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Interaction of Infall and Winds in Young Stellar Objects

, 1999
Guy Delamarter, Adam Frank, Lee Hartmann
openalex   +1 more source

Simulations of stellar/pulsar-wind interaction along one full orbit [PDF]

, 2012
V. Bosch-Ramon, M. V. Barkov, D. Khangulyan, M. Perucho   +3 more
openalex   +1 more source