Results 21 to 30 of about 12,666,103 (318)
Challenges and Controversies in Human Mesenchymal Stem Cell Therapy
Stem Cells International, 2019 Stem cell therapy is being intensely investigated within the last years. Expectations are high regarding mesenchymal stem cell (MSC) treatment in translational medicine. However, many aspects concerning MSC therapy should be profoundly defined.
B. Lukomska +5 more
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PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development
Communications Biology, 2022 The transcription factor PU.1 recruits c-Jun as a co-activator to promoters without AP-1 binding sites, and mice with point mutations in PU.1 that disrupts the interaction between PU1 and c-Jun have defects in PU.1 dependent blood lineages, including ...
Xinhui Zhao +13 more
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MicroRNAs as Important Regulators Mediate the Multiple Differentiation of Mesenchymal Stromal Cells
Frontiers in Cell and Developmental Biology, 2021 MicroRNAs (miRNAs) are endogenous short non-encoding RNAs which play a critical role on the output of the proteins, and influence multiple biological characteristics of the cells and physiological processes in the body.
Chao Yang +5 more
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Mesenchymal Stem Cell Migration and Tissue Repair
Cells, 2019 Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, which play key roles in tissue healing and regenerative medicine.
Xiaorong Fu +5 more
semanticscholar +1 more source
Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway
eLife, 2014 Dysfunction or death of pancreatic β cells underlies both types of diabetes. This functional decline begins with β cell stress and de-differentiation. Current drugs for type 2 diabetes (T2D) lower blood glucose levels but they do not directly alleviate β
Barak Blum +9 more
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Protocol to assess fatal embolism risks from human stem cells
STAR Protocols, 2023 Summary: Here, we present a protocol to identify the pro-embolic sub-population of human adipose-derived multipotent stromal cells (ADSCs) and predict fatal embolism risks from ADSC infusion.
Fei Ma +7 more
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Ethical and Safety Issues of Stem Cell-Based Therapy
International Journal of Medical Sciences, 2018 Results obtained from completed and on-going clinical studies indicate huge therapeutic potential of stem cell-based therapy in the treatment of degenerative, autoimmune and genetic disorders.
V. Volarevic +9 more
semanticscholar +1 more source
Nature Communications, 2019 Pluripotent stem cells can be directed into insulin-producing beta cells in vitro. Here, the authors show that downregulation of YAP, an effector of the Hippo pathway, enhances endocrine progenitor differentiation and the generation of beta-cells with ...
Edwin A. Rosado-Olivieri +3 more
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Hydrogels with tunable stress relaxation regulate stem cell fate and activity
Nature Materials, 2015 Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation. However, hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically elastic.
Ovijit Chaudhuri +10 more
semanticscholar +1 more source