Results 41 to 50 of about 817,109 (355)
Bioengineering, 2021 The recapitulation of the stem cell microenvironment is an emerging area of research that has grown significantly in the last 10 to 15 years. Being able to understand the underlying mechanisms that relate stem cell behavior to the physical environment in
David H. Ramos-Rodriguez +3 more
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Hacking the stem cell niche [PDF]
Blood, 2017 In this issue of Blood , Stoddart et al think outside of the stem cell “box” to identify a therapeutically tractable pathway in del(5q) myelodysplastic syndrome (MDS), through blocking pathologically activated Wnt signaling arising within the stem cell niche ...
Steven W. Lane, Florian H. Heidel
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E-cadherin is required for centrosome and spindle orientation in Drosophila male germline stem cells. [PDF]
PLoS ONE, 2010 Many adult stem cells reside in a special microenvironment known as the niche, where they receive essential signals that specify stem cell identity.
Mayu Inaba +4 more
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Resistin Regulates Inflammation and Insulin Resistance in Humans via the Endocannabinoid System
ResearchResistin plays an important role in the pathophysiology of obesity-mediated insulin resistance in mice. However, the biology of resistin in humans is quite different from that in rodents. Therefore, the association between resistin and insulin resistance
Han-Mo Yang +11 more
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Companion Blood Cells Control Ovarian Stem Cell Niche Microenvironment and Homeostasis
Cell Reports, 2015 The extracellular matrix plays an essential role for stem cell differentiation and niche homeostasis. Yet, the origin and mechanism of assembly of the stem cell niche microenvironment remain poorly characterized.
Véronique Van De Bor +7 more
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Niche formation and function in developing tissue: studies from the Drosophila ovary
Cell Communication and Signaling, 2023 Adult stem cells have a unique ability to self-renew and to generate differentiated daughter cells that are required in the body tissues. The identity of adult stem cells is maintained by extrinsic signals from other cell types, known as niche cells ...
Jian Jin, Ting Zhao
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Sas-Ptp10D shapes germ-line stem cell niche by facilitating JNK-mediated apoptosis.
PLoS Genetics, 2023 The function of the stem cell system is supported by a stereotypical shape of the niche structure. In Drosophila ovarian germarium, somatic cap cells form a dish-like niche structure that allows only two or three germ-line stem cells (GSCs) reside in the
Kiichiro Taniguchi, Tatsushi Igaki
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Stem Cell Niches: Famished Paneth Cells, Gluttonous Stem Cells [PDF]
Current Biology, 2012 Adult tissue stem cells adjust to environmental changes. A new study in the mouse intestine reveals that caloric restriction causes Paneth cells to repress mTORC1 signaling; this in turn stimulates proliferation of neighboring stem cells.
Kim, Tae-Hee, Shivdasani, Ramesh A.
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Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
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Manipulation of signaling thresholds in "engineered stem cell niches" identifies design criteria for pluripotent stem cell screens. [PDF]
PLoS ONE, 2009 In vivo, stem cell fate is regulated by local microenvironmental parameters. Governing parameters in this stem cell niche include soluble factors, extra-cellular matrix, and cell-cell interactions.
Raheem Peerani +4 more
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