Results 131 to 140 of about 2,553,640 (363)

Endocannabinoids increase human adipose stem cell differentiation and growth factor secretion in vitro [PDF]

, 2020
Tim Ruhl, Pia‐Alina Schneider, Bong‐Sung Kim, Justus P. Beier   +3 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Comparative Study on the Effects of Mesenchymal Stem Cells and Their Conditioned Medium on Caco-2 Cells as an In Vitro Model for Inflammatory Bowel Disease

International Journal of Cell Biology
Recent research indicates that mesenchymal stem cells (MSCs), known for their anti-inflammatory and anti-infectious properties, could be a promising alternative for treating inflammatory diseases such as inflammatory bowel disease (IBD).
Naser Kalhor, Hoda Fazaeli, Faezeh Davoodi Asl, Azar Sheikholeslami, Seyed Jalal Eshagh Hoseini, Mohsen Sheykhhasan   +5 more
doaj   +1 more source

Soluble matrix protein is a potent modulator of mesenchymal stem cell performance [PDF]

, 2019
Giselle C. Yeo, Anthony S. Weiss
openalex   +1 more source

Furanocoumarin Notopterol: Inhibition of Hepatocellular Carcinogenesis through Suppression of Cancer Stemness Signaling and Induction of Oxidative Stress-Associated Cell Death [PDF]

, 2023
Ting-Yun Huang, Ching-Kuo Yang, Ming‐Yao Chen, Vijesh Kumar Yadav, Iat-Hang Fong, Chi‐Tai Yeh, Yih‐Giun Cherng   +6 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Retracted: The Mechanism of Oxidative Stress in Cells Isolation, Identification, and Genome-Wide Sequence Analysis of Nitrite Amylolytic Bacillus

Stem Cells International, 2023
Stem Cells International
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Theory of Robustness of Irreversible Differentiation in a Stem Cell System: Chaos hypothesis

, 2000
Based on extensive study of a dynamical systems model of the development of a cell society, a novel theory for stem cell differentiation and its regulation is proposed as the ``chaos hypothesis''.
Furusawa, Chikara, Kaneko, Kunihiko
core   +3 more sources

RH genotyping in a sickle cell disease patient contributing to hematopoietic stem cell transplantation donor selection and management [PDF]

, 2010
Ross M. Fasano, Alessandro Monaco, Emily Riehm Meier, Philippe Pary, A. Hallie Lee‐Stroka, John Otridge, Harvey G. Klein, Francesco M. Marincola, Naynesh Kamani, Naomi L.C. Luban, David F. Stroncek, Willy A. Flegel   +11 more
openalex   +1 more source