Results 191 to 200 of about 138,145 (310)

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

ChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo, Geradius Deogratias, James E. Mgaya, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source

Terpenes as Naturally Occurring Stereochemical Templates: Conformationally Driven Discovery of Reactivity. [PDF]

Org Lett
Arto O, Miguélez R, Siera H, Schulte J, Merino I, Haberhauer G, Barrio P.   +6 more
europepmc   +1 more source

Some aspects of the conformation and stereochemistry of four-membered ring heterocycles / by Evan Hale Williams

, 1980
Evan H. Williams
openalex   +1 more source

Absolute stereochemistry of fungal metabolites: icterinoidins A1 and B1, and atrovirins B1 and B2

, 2004
Melvyn Gill, Peter M. Morgan
openalex   +2 more sources

Stereochemical Studies of Monoterpene Compounds. VI. The Stereochemistry of 2-Hydroxypinocamphone and Its Reduction Products [PDF]

, 1968
Takayuki Suga, Tsuyoshi Shishibori, Toshifumi Hirata, Tamon Matsuura   +3 more
openalex   +1 more source

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner   +2 more
wiley   +1 more source

Ancient gene clusters govern the initiation of monoterpenoid indole alkaloid biosynthesis and C3 stereochemistry inversion. [PDF]

Nat Commun
Hwang J, Kirshner J, Deschênes DAR, Richardson MB, Fleck SJ, Mann SGA, Guo J, Perley JO, Shahsavarani M, Garza-Garcia JJO, Seveck AD, Doiron SS, Mai Z, Silliphant SN, Englehart SA, Blight BA, Calhoun L, Gao D, Lian J, Deslongchamps G, Albert VA, Qu Y.   +21 more
europepmc   +1 more source

The Stereochemistry of N-tert-Butyl-4-(4-hydroxyphenyl)-4-phenyl-2-butylamines. [PDF]

, 1988
Anne Helander, Lennart Kenne, Bengt Norén, Anna‐Britta Hörnfeldt, Harri Lönnberg, Jan-Eric Berg, Mihály Bartók, István Pelczer, György Dombi   +8 more
openalex   +1 more source

Enhancing Lipidomics With High‐Resolution Ion Mobility‐Mass Spectrometry

PROTEOMICS, EarlyView.
ABSTRACT Lipids, indispensable yet structurally intricate biomolecules, serve as critical regulators of cellular function and disease progression. Conventional lipidomics, constrained by limited resolution for isomeric and low‐abundance species, has been transformed by ion mobility‐mass spectrometry (IM‐MS).
Gaoyuan Lu, Shuling Xu, Penghsuan Huang, Lingjun Li   +3 more
wiley   +1 more source

Biosynthesis of the 5-Isoxazolidinone-Containing Hexacyclic Structure of Parnafungin. [PDF]

J Am Chem Soc
Sun Z, Yost KM, Bills GF, Tang Y.
europepmc   +1 more source