Results 61 to 70 of about 138,145 (310)

Asymmetric Hydride Shift Reactions Catalyzed by Chiral Aluminium Complexes

Angewandte Chemie, EarlyView.
An asymmetric intramolecular hydride shift reaction has been developed that is catalyzed by Al Lewis acids in conjunction with a chiral BINOL‐derived ligand. Racemic THP substrates are transformed into cyclohexene products via an intermediate prochiral enone; which undergoes a key 1,5‐hydride shift reaction.
Mostafa M. Amer, Jingyan Hou, Jinfang Wang, Akvile Mazeikaite, Timothy J. Donohoe   +4 more
wiley   +2 more sources

General Anesthetics: Aspects of Chirality, Pharmacodynamics, and Pharmacokinetics

Pharmaceuticals
The introduction of general anesthetics in the mid-19th century is considered one of the greatest contributions to medical practice. It was the first time that complicated surgical interventions became feasible, without putting an excessive strain on the
Ružena Čižmáriková, Ladislav Habala, Jindra Valentová   +2 more
doaj   +1 more source

Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography [PDF]

, 2017
By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (-)-Δ(9)-THC in medicinal marijuana (Bedrocan®).
Cavazzini, A, D'Acquarica, I, Gasparrini, F., Ismail, O, Manzo, C, Mazzoccanti, G, Villani, C, Wilcox, M   +7 more
core   +2 more sources

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

Divergent Total Synthesis of Denudatine Alkaloids Cochlearenine, Macrocentrine, Dictizine, 15‐Veratroyl‐17‐Acetyl‐19‐Oxodictizine, and the Proposed Structure of Acochlearine

Angewandte Chemie, EarlyView.
An intramolecular Mannich reaction (A/B/E/F rings) and intermolecular Diels–Alder reactions (C/D rings) afforded a cage‐like hexacyclic core skeleton of denudatine alkaloids. Derivatization of the hexacyclic intermediate enabled the first asymmetric total syntheses of four denudatine alkaloids: (–)‐cochlearenine, (–)‐macrocentrine, (–)‐dictizine, and (–
Shun Kawano, Naoya Miyamoto, Kosuke Fujioka, Hiroki Toya, Juri Sakata, Hidetoshi Tokuyama   +5 more
wiley   +2 more sources

Biologically Important Eremophilane Sesquiterpenes from Alaska Cedar Heartwood Essential Oil and Their Semi-Synthetic Derivatives

Molecules, 2011
The essential oil of Alaska cedar heartwood is known to contain compounds which contribute to the remarkable durability of this species. While previous research has identified several compounds, a complete description of this oil has not been undertaken.
Joe J. Karchesy, Javier Peralta-Cruz, Mohammad A. Khasawneh, Yeping Xiong   +3 more
doaj   +1 more source

General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers. [PDF]

, 2014
Islet amyloid polypeptide (IAPP or amylin) forms amyloid deposits in the islets of Langerhans; a process that is believed to contribute to the progression of type 2 diabetes and to the failure of islet transplants.
Raleigh, David, Wang, Hui
core   +2 more sources

Higher‐Level Structural Classification of Pseudomonas Cyclic Lipopeptides through Their Bioactive Conformation

Advanced Science, EarlyView.
Solution structures of a series of cyclic lipodepsipeptides from Pseudomonas reveal that these specialized metabolites adopt left‐handed alpha helical conformations of only two types, being either ‘stapled’ or ‘catch‐pole’ helix. The particular modular distribution of the biosynthetic gene clusters is found to determine the extent of their conserved ...
Benjámin Kovács, Durga Prasad, Vic De Roo, Matthias Vanheede, Penthip Muangkaew, Annemieke Madder, Monica Höfte, René De Mot, Niels Geudens, José C. Martins   +9 more
wiley   +1 more source

Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues

Angewandte Chemie, EarlyView.
Marine polyhydroxylated macrolides’ drug discovery potential is limited by structural complexity and scarce material supply, hindering structure assignment, synthesis, and biological studies. Here, we present an integrated workflow that combines chemogenomic profiling, ultra‐high‐resolution NMR‐guided structural revision and stereochemical assignment ...
Malcolm R. P. George, Lobna A. Elsadek, Max Deering, Larissa Costa de Almeida, Jasper L. Tyler, Adam Noble, Valerie J. Paul, Hendrik Luesch, Craig P. Butts, Varinder K. Aggarwal   +9 more
wiley   +2 more sources

A detailed view on 1,8-cineol biosynthesis by Streptomyces clavuligerus

Beilstein Journal of Organic Chemistry, 2016
The stereochemical course of the cyclisation reaction catalysed by the bacterial 1,8-cineol synthase from Streptomyces clavuligerus was investigated using stereospecifically deuterated substrates.
Jan Rinkel, Patrick Rabe, Laura zur Horst, Jeroen S. Dickschat   +3 more
doaj   +1 more source