Results 61 to 70 of about 174,911 (284)
Molecules, 2021 PF74 is a capsid-targeting inhibitor of HIV replication that effectively perturbs the highly sensitive viral uncoating process. A lack of information regarding the optical purity (enantiomeric excess) of the single stereogenic centre of PF74 has resulted
Stuart Ruddell +5 more
doaj +1 more source
Lancifodilactone G : insights about an unusually stable enol [PDF]
, 2008 From quantum mechanics calculations we confirm that the naturally occurring enol lancifodilactone G is stable over the keto form (by 2.6 kcal/mol in water), the only known stable aliphatic enol (devoid of conjugated or bulky aromatics and lacking a 1,3 ...
Chenoweth, D. M. +2 more
core +1 more source
Ipertrofan Revisited—The Proposal of the Complete Stereochemistry of Mepartricin A and B
Molecules, 2021 Being a methyl ester of partricin, the mepartricin complex is the active substance of a drug called Ipertrofan (Tricandil), which was proven to be useful in treatment of benign prostatic hyperplasia and chronic nonbacterial prostatitis/chronic pelvic ...
Paweł Szczeblewski +5 more
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Chiral drugs : one drug or two? : Clinical pharmacology through the looking glass : reflections on the racemate vs enantiomer debate [PDF]
, 1994 Most of the synthetic chiral agents administered as drugs are still marketed as racemic mixtures. Such drug enantiomers can differ substantially in their pharmacological, pharmacokinetic and toxic properties.
Mifsud, Janet
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Beilstein Journal of Organic Chemistry, 2012 Mycoplasma fermentans possesses unique α-glycolipid antigens (GGPL-I and GGPL-III) at the cytoplasm membrane, which carry a phosphocholine group at the sugar primary (6-OH) position.
Yoshihiro Nishida +6 more
doaj +1 more source
Diels–Alder reaction of β-fluoro-β-nitrostyrenes with cyclic dienes
Beilstein Journal of Organic Chemistry, 2021 The Diels–Alder reaction of β-fluoro-β-nitrostyrenes with cyclic 1,3-dienes was investigated. A series of novel monofluorinated norbornenes was prepared in up to 97% yield.
Savva A. Ponomarev +7 more
doaj +1 more source
Condensed Matter, 2021 AsF3E as a representative of a molecular crystal has been chosen to find the precise localization of the lone pair (LP) E centroid 4s2 of As3+ and to enlighten the behavior of lone pair triplets of fluorine atoms. Starting from stereochemistry rationale,
Jean Galy, Samir F. Matar
doaj +1 more source
Stereochemical outcomes of C–F activation reactions of benzyl fluoride
Beilstein Journal of Organic Chemistry, 2018 In recent years, the highly polar C–F bond has been utilised in activation chemistry despite its low reactivity to traditional nucleophiles, when compared to other C–X halogen bonds.
Neil S. Keddie +4 more
doaj +1 more source
Free radical 5-exo-dig cyclization as the key step in the synthesis of bis-butyrolactone natural products: experimental and theoretical studies [PDF]
, 2011 Radical cyclization reactions were performed by 5-exo-dig mode to yield cis-fused bicyclic systems, leading to the synthesis of bis-butyrolactone class of natural products.
Allinger +23 more
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A Failed Encounter in Mathematics and Chemistry: The Folded Models of van ‘t Hoff and Sachse [PDF]
, 2016 Three-dimensional material models of molecules were used throughout the 19th century, either functioning as a mere representation or opening new epistemic horizons. In this paper, two case studies are examined: the 1875 models of van ‘t Hoff and the 1890
Friedman, Michael
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