Results 61 to 70 of about 166,235 (318)

Crystal structure, computational study, and Hirshfeld analysis of exo-1,2,3,5-tetraphenyl-1a',9b'-dihydrospiro[bicyclo[3.1.0]hexane-6,1′-cyclopropa[l]phenanthren]-2-en-4-one

Acta Crystallographica Section E: Crystallographic Communications
The reaction of dibenzonorcarynyliden(e/oid) with phencyclone was recently reported to give a congested spiropentane with endo stereochemistry. Herein we report that, in sharp contrast, an analogous reaction using tetracyclone, instead of phencyclone ...
Alexander D. Roth, Dasan M. Thamattoor
doaj   +1 more source

The C–F bond as a conformational tool in organic and biological chemistry

Beilstein Journal of Organic Chemistry, 2010
Organofluorine compounds are widely used in many different applications, ranging from pharmaceuticals and agrochemicals to advanced materials and polymers.
Luke Hunter
doaj   +1 more source

Highly Diastereo- and Enantioselective Allylboration of Aldehydes using alpha-Substituted Allyl/Crotyl Pinacol Boronic Esters via in Situ Generated Borinic Esters [PDF]

, 2013
Readily available, alpha-substituted allyl/crotyl pinacol boronic esters often give low E/Z selectivity (with Z favored) in reactions with aldehydes. We found that addition of nBuLi to the pinacol boronic ester followed by trapping of the alkoxide with ...
Althaus M., Andersen M. W., Batey R. A., Batey R. A., Beckmann E., Blais J., Brown H. C., Brown H. C., Brown H. C., Brown H. C., Bubnov Y. N., Carosi L., Carosi L., Chemler S. R., Chen M., Chen M., Christine L. Willis, Cmrecki V., Cole T. E., Denmark S. E., Fang G. Y., Flamme E. M., Gonzalez A. Z., Guzman-Martinez A., Hancock K. G., Helen K. Scott, Hesse M. J., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Ito H., Jack L.-Y. Chen, Kennedy J. W. J., Kister J., Kliman L. T., Kramer G. W., Lachance H., Larouche-Gauthier R., Matteson D. S., Matthew J. Hesse, Midland M. M., Park J. K., Pelz N. F., Peng F., Peng F., Pietruszka J., Pietruszka J., Posseme F., Pulis A., Ramachandran P. V., Shiner C. S., Sonawane R. P., Stymiest J. L., Varinder K. Aggarwal, Webster M. P., Woodward A. R., Yamamoto Y., Zschage O.   +60 more
core   +2 more sources

Enantioselective Reductive Alkenylation of α‐CF2H (‐CF3) Amino Halides: Rapid Access to Chiral α‐CF2H (‐CF3) Allylamines

Advanced Science, EarlyView.
Difluoromethyl (CF2H) group, the bioisostere of hydroxyl thiol methyl or amide is privileged in medicinal chemistry due to hydrogen‐binding ability and lipophilic, metabolically stable, and chemical inert nature. However, enatioseleceive CF2H introduction remains challenging.
Peng Liu, Kuiliang Li, Yan He, Chen‐Hui Jiang, Ruo‐Xing Jin, Duo‐Duo Hu, Wei‐Cheng Zhao, Xuan Nie, Shang‐Zheng Sun, Xi‐Sheng Wang   +9 more
wiley   +1 more source

Botrylactone: new interest in an old moleculedreview of its absolute configuration and related compounds [PDF]

, 2010
The absolute configuration of botrylactone, a unique compound with an interesting polyketide lactone skeleton with two oxirane bridges previously isolated from Botrytis cinerea and described as a powerful antibiotic, has been reviewed on the basis of ...
Durán Patrón, Rosa María, González Collado, Isidro, Hernández Galán, Rosario, Moraga Galindo, Javier, Pinedo Rivilla, Cristina   +4 more
core   +2 more sources

An Overview of Polyphenols and Color Chemistry in Cocoa

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Cocoa polyphenols have been traditionally known for their beneficial properties in human health. However, less is known about their other impacts on cocoa processing. This review highlights current discoveries in the role of polyphenols in the formation of color in cocoa.
Jasmeet Kaur Khanijou, Mario Wibowo
wiley   +1 more source

An easy α-glycosylation methodology for the synthesis and stereochemistry of mycoplasma α-glycolipid antigens

Beilstein Journal of Organic Chemistry, 2012
Mycoplasma fermentans possesses unique α-glycolipid antigens (GGPL-I and GGPL-III) at the cytoplasm membrane, which carry a phosphocholine group at the sugar primary (6-OH) position.
Yoshihiro Nishida, Yuko Shingu, Yuan Mengfei, Kazuo Fukuda, Hirofumi Dohi, Sachie Matsuda, Kazuhiro Matsuda   +6 more
doaj   +1 more source

Synthesis and Structure-Activity Relationships of Novel Ecdysteroid Dioxolanes as MDR Modulators in Cancer

Molecules, 2013
Ecdysteroids, molting hormones of insects, can exert several mild, non-hormonal bioactivities in mammals, including humans. In a previous study, we have found a significant effect of certain derivatives on the ABCB1 transporter mediated multi-drug ...
Ana Martins, József Csábi, Attila Balázs, Diána Kitka, Leonard Amaral, József Molnár, András Simon, Gábor Tóth, Attila Hunyadi   +8 more
doaj   +1 more source

A Concise Total Synthesis of (--)-Maoecrystal Z [PDF]

, 2011
The first total synthesis of (--)-maoecrystal Z is described. The key steps of the synthesis include a diastereoselective Ti^(III)-mediated reductive epoxide coupling reaction and a diastereoselective Sm^(II)-mediated reductive cascade cyclization ...
Cha, Jacob Y., Reisman, Sarah E., Yeoman, John T. S.   +2 more
core   +2 more sources

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source