Results 71 to 80 of about 177,307 (324)

Identification of Components of the Aggregation Pheromone of the Guam Strain of Coconut Rhinoceros Beetle, Oryctes rhinoceros, and Determination of Stereochemistry [PDF]

, 2021
David R. Hall, Steven J. Harte, Dudley I. Farman, Mark Ero, Alfred Pokana   +4 more
openalex   +1 more source

P‐Stereogenic Phosphines via Mn(I)‐Catalyzed Asymmetric Hydrophosphination of Vinyl Sulfones: A Case of Solvent‐Induced Stereoinversion

Advanced Synthesis &Catalysis, EarlyView.
A new strategy for synthesis of P‐chiral phosphines via manganese‐catalyzed enantioselective hydrophosphination was established. The solvent like iPrOH was found to be able to tune the enantioselectivity of the product, thus providing both enantiomers of P(III)‐stereogenic compounds with a single (Rc, Sp)‐Clarke Mn(I) complex catalyst. In this work, we
Bin Wan, Syuzanna R. Harutyunyan
wiley   +1 more source

Spatial Assembly of Mechanically Planar Chiral Rotaxanes on Rationally Designed Cavitands

Angewandte Chemie, EarlyView.
A spatial molecular assembly strategy enables the synthesis of enantioenriched mechanically planar chiral rotaxanes. Inherently chiral cavitands are rationally designed to encode and transmit the stereochemical information. Predictable stereochemical induction is achieved by controlling the spatial arrangement of molecular components through ...
Liwen Xia, Wenyang Hong, Chong Tian, Ye Zhu   +3 more
wiley   +2 more sources

Biologically Important Eremophilane Sesquiterpenes from Alaska Cedar Heartwood Essential Oil and Their Semi-Synthetic Derivatives

Molecules, 2011
The essential oil of Alaska cedar heartwood is known to contain compounds which contribute to the remarkable durability of this species. While previous research has identified several compounds, a complete description of this oil has not been undertaken.
Joe J. Karchesy, Javier Peralta-Cruz, Mohammad A. Khasawneh, Yeping Xiong   +3 more
doaj   +1 more source

Interpretable PROTAC Degradation Prediction With Structure‐Informed Deep Ternary Attention Framework

Advanced Science, EarlyView.
PROTAC‐STAN, a structure‐informed deep learning framework is presented for interpretable PROTAC degradation prediction. By modeling molecular hierarchies and protein structures, and simulating ternary interactions via a novel attention network, PROTAC‐STAN achieves significant performance gains over baselines.
Zhenglu Chen, Chunbin Gu, Shuoyan Tan, Xiaorui Wang, Yuquan Li, Mutian He, Ruiqiang Lu, Shijia Sun, Chang‐Yu Hsieh, Xiaojun Yao, Huanxiang Liu, Pheng‐Ann Heng   +11 more
wiley   +1 more source

Cooperative Brønsted Acid and Photo‐Promoted Stereoselective Synthesis of Substituted Piperidones

Angewandte Chemie, EarlyView.
A Brønsted acid cooperates with a photoexcited carbonyl triplet to promote stereoselective C─C bond formation in disubstituted piperidones through a chromophore‐activator strategy. The Brønsted acid lowers the excitation energy gap, directs selective C─N bond cleavage over C─C fragmentation after H‐atom transfer, and enables enantioselective C─C bond ...
Qiupeng Peng, Poulami Mukherjee, Adhya Suresh, Meemie Hwang, Osvaldo Gutierrez, Karl A. Scheidt   +5 more
wiley   +2 more sources

A detailed view on 1,8-cineol biosynthesis by Streptomyces clavuligerus

Beilstein Journal of Organic Chemistry, 2016
The stereochemical course of the cyclisation reaction catalysed by the bacterial 1,8-cineol synthase from Streptomyces clavuligerus was investigated using stereospecifically deuterated substrates.
Jan Rinkel, Patrick Rabe, Laura zur Horst, Jeroen S. Dickschat   +3 more
doaj   +1 more source

Free radical 5-exo-dig cyclization as the key step in the synthesis of bis-butyrolactone natural products: experimental and theoretical studies [PDF]

, 2011
Radical cyclization reactions were performed by 5-exo-dig mode to yield cis-fused bicyclic systems, leading to the synthesis of bis-butyrolactone class of natural products.
Allinger, Baldwin, Beckwith, Beckwith, Beckwith, Blot, Cossy, Curtiss, Devoju Harinada Chary, Florian Achrainer, Gangavaram V. M. Sharma, Hendrik Zipse, Lii, Lii, Nagula Chandramouli, Sateesh Patrudu, Sharma, Sharma, Sharma, Sharma, Sharma, Sharma, Srikrishna, Yu   +23 more
core   +1 more source

Steric‐Adaptive Biocatalysis: Imine Reductase‐Mediated Dynamic Kinetic Resolution for Atroposelective Synthesis of Hindered Biaryl Amines

Advanced Science, EarlyView.
An unusual IRED platform is reported, enabling efficient DKR via reductive amination without any evolutionary engineering. The system accommodates extremely sterically demanding substrates, including naphthyl and quinoline derivatives, delivering naphthyl‐aryl and quinoline‐aryl amine atropisomers with excellent efficiency and stereocontrol (over 80 ...
Zhichao Ni, Jingyuan Zhuang, Yadong Gao, Guangsheng Gao, Zhenling Liu, Ping Su, Gui‐Juan Cheng, Li‐Cheng Yang   +7 more
wiley   +1 more source

Defluoroalkylation of Trifluoromethane with Organolithium Reagents: Mechanism and Synthesis of Fluoroalkenes

Angewandte Chemie, EarlyView.
We report a rare example of the transformation of HCF3 into a fluoroalkene functional group through defluoroalkylation. We rationalise product formation through DFT calculations, scale‐up the synthesis through continuous flow methods, and show that a fluoroalkene reagent derived from HCF3 is a competent nucleophile for the fluoroethenylation of a range
Hodan R. Warsame, Sarah L. Patrick, James A. Bull, Philip W. Miller, Mark R. Crimmin   +4 more
wiley   +2 more sources