Results 71 to 80 of about 176,257 (369)

On biological homochirality [PDF]

, 2009
Generalizing Landau's spontaneous symmetry breaking arguments using the standard groupoid approach to stereochemistry allows reconsideration of the origin of biological homochirality.
Rodrick Wallace
core   +1 more source

Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis [PDF]

, 2014
An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning ...
Aldegunde M. J., Aldegunde M. J., Aldegunde M. J., Aurélien Letort, Bourgeois D., Bourgeois D., Bourgeois D., Bourgeois D., Bourgeois D., Chatterjee A. K., Cong Ma, De-Liang Long, Doi T., Garber S. B., Goldring P. D., Grieco P. A., Holton R. A., Holton R. A., Joëlle Prunet, Kim S.-H., Ma C., Masters J. J., Mendoza A., Morihara K., Mukaiyama T., Muller B., Muller B., Nicolaou K. C., Rémi Aouzal, Schiltz S., Scholl M., Schwab P., Swindell C. S., Wender P. A., Wender P. A., Wilde N. C., Winkler J. D., Yamazaki Y., Yared J. A., Yvon D.   +39 more
core   +3 more sources

Visible‐Light Photocatalyzed Selective Synthesis of 1,2‐ or 1,3‐Dithianes From Thietanes: An Experimental and Theoretical Study

Advanced Synthesis &Catalysis, EarlyView.
Although this article formally presents a regioselective photochemical ring enlargement of thietanes into 1,2‐ or 1,3‐dithianes, time‐dependent density functional theory calculations have revealed that 1,3‐dithianes are in fact formed thought photoinduced hydrogen atom transfers from 1,2‐dithianes initially resulting from the ring enlargement using ...
Gabriel Cormier, Manuel Pedrón, Maria I. Lapuh, Regis Guillot, Ilaria Ciofini, Thomas Boddaert   +5 more
wiley   +1 more source

Electrochemical ⍺‐C─H Functionalization of Nitramines for Accessing Bifunctional Energetic Heterocycles

Angewandte Chemie, EarlyView.
An electrochemical α‐C─H functionalization of nitramines enables the synthesis of molecules containing bifunctional energetic heterocycles with promising properties. A telescoped, HNO3‐free sequence involving nitration and azolation steps offers a safer, modular, and scalable platform for the synthesis of energetic compounds.
Wan‐Chen Cindy Lee, Luiz F. T. Novaes, Rojan Ali, Thomas Wirth, Song Lin   +4 more
wiley   +2 more sources

Stereochemistry. [PDF]

Journal of the American Chemical Society, 1908
n ...
openaire   +1 more source

Interpretable PROTAC Degradation Prediction With Structure‐Informed Deep Ternary Attention Framework

Advanced Science, EarlyView.
PROTAC‐STAN, a structure‐informed deep learning framework is presented for interpretable PROTAC degradation prediction. By modeling molecular hierarchies and protein structures, and simulating ternary interactions via a novel attention network, PROTAC‐STAN achieves significant performance gains over baselines.
Zhenglu Chen, Chunbin Gu, Shuoyan Tan, Xiaorui Wang, Yuquan Li, Mutian He, Ruiqiang Lu, Shijia Sun, Chang‐Yu Hsieh, Xiaojun Yao, Huanxiang Liu, Pheng‐Ann Heng   +11 more
wiley   +1 more source

Toward Iron‐Catalyzed Alkene Metathesis: Mapping the Reactivity and Deactivation Pathways of an Iron Metallacyclobutane

Angewandte Chemie, EarlyView.
Iron‐catalyzed alkene metathesis has long remained elusive. This study identifies β‐hydride elimination from an iron metallacyclobutane as a key deactivation pathway in iron‐catalyzed alkene metathesis, through combined computational and experimental efforts.
Katarzyna Młodzikowska‐Pieńko, Jatin Panda, Subhash Garhwal, Alexander Kaushansky, Tobias Krämer, Renana Gershoni‐Poranne, Graham de Ruiter   +6 more
wiley   +2 more sources

An easy α-glycosylation methodology for the synthesis and stereochemistry of mycoplasma α-glycolipid antigens

Beilstein Journal of Organic Chemistry, 2012
Mycoplasma fermentans possesses unique α-glycolipid antigens (GGPL-I and GGPL-III) at the cytoplasm membrane, which carry a phosphocholine group at the sugar primary (6-OH) position.
Yoshihiro Nishida, Yuko Shingu, Yuan Mengfei, Kazuo Fukuda, Hirofumi Dohi, Sachie Matsuda, Kazuhiro Matsuda   +6 more
doaj   +1 more source

Stereochemistry of Astaxanthin Biosynthesis in the Marine Harpacticoid Copepod Tigriopus Californicus

Marine Drugs, 2020
The harpacticoid copepod Tigriopus californicus has been recognized as a model organism for the study of marine pollutants. Furthermore, the nutritional profile of this copepod is of interest to the aquafeed industry.
Alfonso Prado-Cabrero, Ganjar Saefurahman, John M. Nolan   +2 more
doaj   +1 more source

Lancifodilactone G : insights about an unusually stable enol [PDF]

, 2008
From quantum mechanics calculations we confirm that the naturally occurring enol lancifodilactone G is stable over the keto form (by 2.6 kcal/mol in water), the only known stable aliphatic enol (devoid of conjugated or bulky aromatics and lacking a 1,3 ...
Chenoweth, D. M., Chenoweth, K., Goddard, W. A., III   +2 more
core   +1 more source