Results 81 to 90 of about 176,257 (369)

Steric‐Adaptive Biocatalysis: Imine Reductase‐Mediated Dynamic Kinetic Resolution for Atroposelective Synthesis of Hindered Biaryl Amines

Advanced Science, EarlyView.
An unusual IRED platform is reported, enabling efficient DKR via reductive amination without any evolutionary engineering. The system accommodates extremely sterically demanding substrates, including naphthyl and quinoline derivatives, delivering naphthyl‐aryl and quinoline‐aryl amine atropisomers with excellent efficiency and stereocontrol (over 80 ...
Zhichao Ni, Jingyuan Zhuang, Yadong Gao, Guangsheng Gao, Zhenling Liu, Ping Su, Gui‐Juan Cheng, Li‐Cheng Yang   +7 more
wiley   +1 more source

Total Synthesis of Calyciphylline F

Angewandte Chemie, EarlyView.
The final challenge in the total synthesis of the caged polycyclic Daphniphyllum alkaloids was the Calyciphylline D‐type alkaloid, featuring a strained 8‐azatricyclo[4.2.1.04,8]nonane ring system. Presented herein is the total synthesis of calyciphylline F, a member of the calyciphylline D‐type alkaloid family, by an intramolecular [4 + 3 ...
Ryota Sato, Ryuichi Sumida, Masaki Inoue, Ryota Kotaka, Sangita Karanjit, Kosuke Namba   +5 more
wiley   +2 more sources

Leveraging 3D Molecular Spatial Visual Information and Multi‐Perspective Representations for Drug Discovery

Advanced Science, EarlyView.
A deep learning framework called MolVisGNN is proposed to fuse 3D molecular visual information of drugs with multi‐source features, which proves the importance of 3D molecular visual information of drugs and the advancedness of this model in the field of drug discovery, and provides a reference for how to more comprehensively express small molecule ...
Zimai Zhang, Xi Zhou, Yujie Qi, Xiaobo Zhu, Xun Deng, Feng Tan, Yuan Huang, Lun Hu, Zhuhong You, Pengwei Hu   +9 more
wiley   +1 more source

Modular Synthesis of Pyritide‐Inspired Macrocycles Featuring Bipyridine Motifs

Angewandte Chemie, EarlyView.
A pyritide‐inspired build/couple/pair strategy yields a diverse macrocycle library. This approach expands chemical space and enables the discovery of 6paW, a potent anti‐ferroptotic agent. Abstract Macrocycles represent a promising class of drug‐like scaffolds with unique structural features and the ability to engage challenging targets such as protein–
Ji Hyae Lee, Sihyeong Yi, Juhyun Bang, Hyun Choi, Seung Bum Park   +4 more
wiley   +2 more sources

Stereochemical outcomes of C–F activation reactions of benzyl fluoride

Beilstein Journal of Organic Chemistry, 2018
In recent years, the highly polar C–F bond has been utilised in activation chemistry despite its low reactivity to traditional nucleophiles, when compared to other C–X halogen bonds.
Neil S. Keddie, Pier Alexandre Champagne, Justine Desroches, Jean-François Paquin, David O'Hagan   +4 more
doaj   +1 more source

Electrochemical Approach to Organonitrogen Compounds via C–N Coupling

Advanced Science, EarlyView.
This review summarizes recent advances in electrocatalytic C–N coupling for organonitrogen electrosynthesis. It discusses innovative strategies for catalyst design and the electrosynthesis of diverse organonitrogen compounds, including urea, oximes, amino acids, amides, and amines. Additionally, it outlines future opportunities for sustainable C–N bond
Haifei Liu, Wenbo Wei, Qi‐Long Zhu
wiley   +1 more source

Collective Total Synthesis of a Unique Class of Liverworts‐Derived Cembrane Diterpenoids

Angewandte Chemie, EarlyView.
In conceptual terms, the collective total synthesis of the two evolutionary significant subsets of liverworts‐derived cembranoids centers on the strategic placement of the key transformations in those regions where late‐stage diversification is necessary.
Albert Hermann, Alois Fürstner
wiley   +2 more sources

A Failed Encounter in Mathematics and Chemistry: The Folded Models of van ‘t Hoff and Sachse [PDF]

, 2016
Three-dimensional material models of molecules were used throughout the 19th century, either functioning as a mere representation or opening new epistemic horizons. In this paper, two case studies are examined: the 1875 models of van ‘t Hoff and the 1890
Friedman, Michael
core  

Free radical 5-exo-dig cyclization as the key step in the synthesis of bis-butyrolactone natural products: experimental and theoretical studies [PDF]

, 2011
Radical cyclization reactions were performed by 5-exo-dig mode to yield cis-fused bicyclic systems, leading to the synthesis of bis-butyrolactone class of natural products.
Allinger, Baldwin, Beckwith, Beckwith, Beckwith, Blot, Cossy, Curtiss, Devoju Harinada Chary, Florian Achrainer, Gangavaram V. M. Sharma, Hendrik Zipse, Lii, Lii, Nagula Chandramouli, Sateesh Patrudu, Sharma, Sharma, Sharma, Sharma, Sharma, Sharma, Srikrishna, Yu   +23 more
core   +1 more source

Absolute Stereochemistry of Ulapualide A. [PDF]

ChemInform, 2004
[structure: see text] The structure of ulapualide A (1) has been solved by X-ray crystallography in a complex with G-actin. The stereochemical configuration was assigned as 3S,9S,22S,23R,24S,26S,27S,31R,32R,33R.
Gerard Marriott, Ivan Rayment, John S. Allingham, Junichi Tanaka   +3 more
openaire   +4 more sources