Results 51 to 60 of about 36,653 (344)

Synthesis and structure of trans-1,2,3- tris(3-thenoyl)cyclopropane [PDF]

, 1994
The title cyclopropane derivative, C18H12O3S3, was synthesized and its structure investigated by single-crystal X-ray diffraction and spectroscopic methods.
Saba, Antonio
core  

Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance [PDF]

, 2010
Glyoxal and methylglyoxal are reactive dicarbonyl metabolites formed and metabolized in physiological systems. Increased exposure to these dicarbonyls is linked to mutagenesis and cytotoxicity and enhanced dicarbonyl metabolism by overexpression of ...
Baynes, Boyum, Brigitte M. Winklhofer-Roob, Cao, Cao, Chan, Chung, Cooke, Cooke, De Bont, Dobler, Duewelhenke, Fleming, Frischmann, Gatenby, Hou, Kang, Krymkiewicz, Larisch, Li, Luo, Michael R. Stratton, Morcos, Naila Rabbani, Nicolay, Papoulis, Paul J. Thornalley, Pfaffl, Pischetsrieder, Rock, Sahar Waris, Sakamoto, Sakamoto, Sarah J. Larkin, Schneider, Seidel, Shapiro, Synold, Thomas Fleming, Thomas Santarius, Thornalley, Thornalley, Thornalley, Thornalley, Thornalley, Vaca, Wang, Yeluri, Yuan   +48 more
core   +2 more sources

Single‐Crystal Organic Field‐Effect Transistors Based on 5,15‐Bisaryl‐Tetrabenzoporphyrins: Synthesis, Structure, and Charge Transport Properties

Advanced Materials Interfaces, EarlyView.
This study explores single‐crystal organic field‐effect transistors (SC‐OFETs) based on 5,15‐bisaryl‐tetrabenzoporphyrin derivatives. It highlights the impact of meso‐substituted groups on molecular packing and charge transport. Among the derivatives, C8Ph‐BP achieves the highest hole mobility (1.64 cm2 V−¹ s−¹) due to enhanced π‐stacking with ...
Kazuya Miyazaki, Kento Teranishi, Hiroshi Matsuda, Kyohei Matsuo, Mitsuaki Yamauchi, Yoshiyuki Mizuhata, Nobutaka Shioya, Takeshi Hasegawa, Hiroko Yamada   +8 more
wiley   +1 more source

Isothiourea‐Catalysed Acylative Kinetic and Dynamic Kinetic Resolution of Planar Chiral Paracyclophanols

Angewandte Chemie, EarlyView.
The highly selective acylative (dynamic) kinetic resolution of racemic paracyclophanols catalysed by a chiral isothiourea (5 mol%) is described (up to s = 50 at 49% conversion or up to 98:2 er and 96% yield in 30 examples). Rotational barriers were analysed for paracyclophanols and selected ester products.
Zhanyu Zhou, Kevin Kasten, Aidan P. McKay, David B. Cordes, Andrew D. Smith   +4 more
wiley   +2 more sources

Integrating Visible‐Light Photocatalysis and Enzymes for the Stereoselective Synthesis of Alcohols and Amines

Advanced Synthesis &Catalysis, EarlyView.
The integration between visible‐light photocatalysis and biocatalysis has the potential to greatly improve modern organic synthesis by combining the production of valuable synthetic intermediates under mild photochemical conditions with the high degree of stereoselectivity reached by enzymes. The review collects the recent efforts in the photoenzymatic
Stefano Parisotto, Cristina Prandi
wiley   +1 more source

Suggesting a Way to Understand the Actual Potential of Anti-Alzheimer's Disease Drugs That Show Promise in Transgenic Mouse Models. [PDF]

, 2017
One conundrum in Alzheimer's disease (AD) research using transgenic mouse models is the high amount of successful memory-enhancing drugs. By contrast, very few drugs and of limited efficacy are available for humans having this pathology.
Franco Fernández, Rafael, Petrovic, Milos   +1 more
core   +1 more source

Q‐GEM: Quantum Chemistry Knowledge Fusion Geometry‐Enhanced Molecular Representation for Property Prediction

Advanced Science, EarlyView.
This work introduces E‐GeoGNN, a graph neural network framework that systematically encodes molecular structural information through three hierarchical correlation graphs: atom‐bond graph, bond‐angle graph, and angle‐dihedral graph. By incorporating quantum and geometric dual‐scale self‐supervised pretraining, Q‐GEM is proposed, a novel molecular ...
Zhijiang Yang, Liangliang Wang, Tengxin Huang, Yunfan Wang, Mingchi Gao, Tingjun Hou, Junjie Ding, Junhua Xiao   +7 more
wiley   +1 more source

Light‐Driven Ratchet Mechanism Accelerates Regioselective Metal‐Cation Exchange in a Heterobimetallic Helicate

Angewandte Chemie, EarlyView.
Photoswitchable homo‐ and heterobimetallic helicates form with high diastereo‐ and regioselectivity via single‐step self‐assembly or self‐sorting. White‐light exposure autonomously operates one helicate as a molecular ratchet, promoting the selective formation of an out‐of‐equilibrium structure.
Maximilian J. Notheis, Gregor Schnakenburg, Larissa K. S. von Krbek   +2 more
wiley   +2 more sources

Host–guest interactions in nor-seco-cucurbit[10]uril: novel guest-dependent molecular recognition and stereoisomerism

Beilstein Journal of Organic Chemistry, 2019
The unique monomer and excimer fluorescence emissions of pyrene were first exploited as distinctly photophysical signals to identify the possible diastereomers of guests within nor-seco-cucurbit[10]uril (NS-CB[10]) cavities.
Xiaodong Zhang, Wei Wu, Zhu Tao, Xin-Long Ni   +3 more
doaj   +1 more source

Phenylalanine‐Based DNA‐Encoded Chemical Libraries for the Discovery of Potent and Selective Small Organic Ligands Against Markers of Cancer and Immune Cells

Advanced Science, EarlyView.
FM‐DEL1 and FM‐DEL2 are constructed by installing one or two sets of building blocks on a phenylalanine central scaffold. FM‐DELs are screened against markers of prostate, and renal cell carcinoma, and against an immunological target expressed on the surface of natural killer cells.
Francesca Migliorini, Andrea Ciamarone, Sheila Dakhel Plaza, Tony Georgiev, Marta Mascellani, Emanuela Sabato, Giulio Vistoli, Ilaria Biancofiore, Nicholas Favalli, Emanuele Puca, Sebastian Oehler, Dario Neri, Samuele Cazzamalli   +12 more
wiley   +1 more source