Results 121 to 130 of about 14,256 (222)

Engineering membrane‐bound alkane monooxygenase from Marinobacter sp. for increased activity in the selective ω‐hy‐droxylation of linear and branched aliphatic esters

Protein Science, Volume 35, Issue 4, April 2026.
Abstract The regio‐ and stereoselective hydroxylation of unactivated C(sp3)‐H bonds is an important reaction in organic synthesis. While bacterial alkane monooxygenase AlkB catalyzes the terminal hydroxylation of aliphatic esters with excellent regioselectivity, the molecular principles of substrate recognition and selectivity of this integral membrane
Jelena Spasic, Andrea Nigl, Huijin Cheon, Christine L. Kaiserer, Stela Galušić, Elske van der Pol, Lenny Malihan‐Yap, Jin‐Byung Park, Robert Kourist   +8 more
wiley   +1 more source

Stereochemical Dissection of the Strobilurin PKS Reveals the Complex Biosynthetic Logic of Iterative EZE Triene Construction. [PDF]

Angew Chem Int Ed Engl
Hauser M, Pang J, Lai D, Sun Y, Yao H, Cox RJ.   +5 more
europepmc   +1 more source

Structural and evolutionary dissection of NADPH‐binding motifs in NADPH‐preferring ene‐reductases

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Ene‐reductases (ERs) catalyze nicotinamide‐dependent, stereoselective reductions of activated CC bonds. While their catalytic chemistry and applications are well‐explored, cosubstrate (NAD(P)H) binding remains poorly understood. Most ERs strongly prefer NADPH despite lacking canonical dinucleotide‐binding folds and instead employ flexible ...
Bianca Kerschbaumer, Eva M. Frießer, Silvia Wallner, Gustav Oberdorfer, Michael Friess, Rolf Breinbauer, Peter Macheroux, Aleksandar Bijelic   +7 more
wiley   +1 more source

Synthesis of an A/B-<i>cis</i>-Fused Cyclopenta[<i>b</i>]fluorene (6/5/6/5) Ring System for Embellicine A via the Eight-Membered Silylene-Tethered IMDA Reaction. [PDF]

Org Lett
Sakai Y, Murata R, Hirakawa A, Nakatani Y, Maeda T, Kuwano Y, Morita S, Uchiro H.   +7 more
europepmc   +1 more source

Transaminase and Norcoclaurine Synthase One‐Pot Cascades Towards (1S)‐Tetrahydroisoquinolines

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
A TAm‐NCS cascade towards THIQs has been established, starting from amines with the in situ production of aldehydes. The cascade was used with a variety of nonfunctionalized and functionalized amines, and reaction conditions modified to enhance formation of the desired cross‐products.
Jianxiong Zhao, Yeke Ni, Yu Wang, John M. Ward, Jack W. E. Jeffries, Helen C. Hailes   +5 more
wiley   +1 more source

Fluorinated Glycan Frameshifts: Automated Synthesis Expedites the Study of Glycan‐Protein Interactions by 19F‐BioNMR

Angewandte Chemie, Volume 138, Issue 12, 16 March 2026.
Given the prominence of 19F‐bioNMR in structural research, fluorinated glycans hold enormous potential in glycomimetic frameshift design. However, challenges associated with the stereocontrolled synthesis of these disruptive actors continue to frustrate advances. To address this, the automated synthesis of selectively C‐2 fluorinated glycans related to
James Suri, Christina Jordan, Charlotte S. Teschers, Kristina Schlangen, Simon H. Rüdisser, Alvar D. Gossert, Ryan Gilmour   +6 more
wiley   +2 more sources

Polytetrafluoroethylene-Assisted Rapid Preparation of α‑Oligomannosides Containing Mannose-6-Phosphate Residues. [PDF]

ACS Omega
Bi P, Feng Y, Chai M, Zhang Q, Chai Y.
europepmc   +1 more source

Stereoselective Bio‐Organocatalytic Cascade to Chiral Amides as Active Pharmaceutical Ingredient Intermediates Using ω‐Transaminase and Choline Chloride Under Microwave Irradiation

ChemSusChem, Volume 19, Issue 6, 27 March 2026.
Amide bond formation is central to active pharmaceutical ingredient (API) synthesis. A bio‐organocatalytic cascade is reported, merging stereoselective ω‐transaminase (ω‐TA) transamination in neat organic solvent with choline chloride‐mediated amidation under solvent‐free microwave conditions.
Salvatore Romano, Matteo Damian, Monica Nardi, Antonio Procopio, Sebastian Strähler, Daniël Preschel, Manuela Oliverio, Francesco G. Mutti   +7 more
wiley   +1 more source

Arylhydrazines: Convenient Homogeneous Reductants for Scalable Cross‐Coupling

Angewandte Chemie, Volume 138, Issue 12, 16 March 2026.
Reductive cross‐couplings enable efficient C–C bond formation but are limited by the heterogeneity of Zn or costly reagents like TDAE. We report arylhydrazines as inexpensive, convenient reductants for Ni‐catalyzed sp2–sp3 coupling of aryl halides and secondary alkyl iodides. Mechanistic studies support hydrazine‐mediated NiII reduction for a NiI/NiIII
Nils Kurig, David A. Cagan, Kaid C. Harper, Yu Kawamata, Donna G. Blackmond, Phil S. Baran   +5 more
wiley   +2 more sources

Stereoselective Ferrier-Type O-Glycosylation Enabled by Difluoromethylated Glycal Donors. [PDF]

Adv Sci (Weinh)
Zou Y, Xu H, Zheng CX, Zhang W, Ye XS, Xiong DC.   +5 more
europepmc   +1 more source