Results 21 to 30 of about 166,370 (359)

Enantioselective Organocatalytic Diels-Alder Trapping of Photochemically Generated Hydroxy-o-Quinodimethanes [PDF]

, 2016
The photoenolization/Diels-Alder strategy offers straightforward access to synthetically valuable benzannulated carbocyclic products. This historical light-triggered process has never before succumbed to efforts to develop an enantioselective catalytic ...
Cuadros, Sara, Dell'Amico, Luca, Melchiorre, Paolo, Vega Pe\uf1aloza, Alberto   +3 more
core   +2 more sources

Stereoselectivity of Interaction of Nonsteroidal Anti-Inflammatory Drug S-Ketoprofen with L/D-Tryptophan in Phospholipid Membranes

Membranes, 2022
The mechanisms of stereoselectivity of the interaction of chiral drugs with active sites of enzymes and cell receptors attract significant attention.
Anna V. Mastova, Olga Yu. Selyutina, Nikolay E. Polyakov   +2 more
doaj   +1 more source

Significance and challenges of stereoselectivity assessing methods in drug metabolism

Journal of Pharmaceutical Analysis, 2016
Stereoselectivity in drug metabolism can not only influence the pharmacological activities, tolerability, safety, and bioavailability of drugs directly, but also cause different kinds of drug–drug interactions.
Zhuowei Shen, Chuang Lv, Su Zeng
doaj   +1 more source

The Synthesis of α-Aminophosphonates via Enantioselective Organocatalytic Reaction of 1-(N-Acylamino)alkylphosphonium Salts with Dimethyl Phosphite

Molecules, 2020
α-Aminophosphonic acids are phosphorus analogues of α-amino acids. Compounds of this type find numerous applications in medicine and crop protection due to their unique biological activities.
Alicja Walęcka-Kurczyk, Krzysztof Walczak, Anna Kuźnik, Sebastian Stecko, Agnieszka Październiok-Holewa   +4 more
doaj   +1 more source

Defining the SN1 Side of Glycosylation Reactions: Stereoselectivity of Glycopyranosyl Cations

ACS Central Science, 2019
The broad application of well-defined synthetic oligosaccharides in glycobiology and glycobiotechnology is largely hampered by the lack of sufficient amounts of synthetic carbohydrate specimens.
Thomas Hansen, Ludivine Lebedel, Wouter A. Remmerswaal, Stefan van der Vorm, Dennis P. A. Wander, Mark Somers, H. Overkleeft, D. Filippov, J. Désiré, Agnès Mingot, Y. Blériot, G. A. van der Marel, S. Thibaudeau, J. Codée   +13 more
semanticscholar   +1 more source

Combined experimental and computational investigations of rhodium-catalysed C-H functionalisation of pyrazoles with alkenes [PDF]

, 2014
Detailed experimental and computational studies have been carried out on the oxidative coupling of the alkenes C(2)H(3)Y (Y=CO(2)Me (a), Ph (b), C(O)Me (c)) with 3-aryl-5-R-pyrazoles (R=Me (1 a), Ph (1 b), CF(3) (1 c)) using a [Rh(MeCN)(3)Cp*][PF(6)](2 ...
Algarra, Andrés G., Davies, David L., Khamker, Qudsia, Macgregor, Stuart A., McMullin, Claire L., Singh, Kuldip, Villa-Marcos, Barbara   +6 more
core   +1 more source

Stereoselectivity Switch in the Reduction of α-Alkyl-β-Arylenones by Structure-Guided Designed Variants of the Ene Reductase OYE1

Frontiers in Bioengineering and Biotechnology, 2019
Ene reductases from the Old Yellow Enzyme (OYE) family are industrially interesting enzymes for the biocatalytic asymmetric reduction of alkenes. To access both enantiomers of the target reduced products, stereocomplementary pairs of OYE enzymes are ...
Michele Crotti, Fabio Parmeggiani, Erica Elisa Ferrandi, Francesco G. Gatti, Alessandro Sacchetti, Sergio Riva, Elisabetta Brenna, Daniela Monti   +7 more
doaj   +1 more source

Functional Characterization and Structural Insights Into Stereoselectivity of Pulegone Reductase in Menthol Biosynthesis

Frontiers in Plant Science, 2021
Monoterpenoids are the main components of plant essential oils and the active components of some traditional Chinese medicinal herbs like Mentha haplocalyx Briq., Nepeta tenuifolia Briq., Perilla frutescens (L.) Britt and Pogostemin cablin (Blanco) Benth.
Chanchan Liu, Chanchan Liu, Qiyu Gao, Zhuo Shang, Jian Liu, Siwei Zhou, Jingjie Dang, Licheng Liu, Iris Lange, Narayanan Srividya, B. Markus Lange, Qinan Wu, Qinan Wu, Wei Lin, Wei Lin, Wei Lin, Wei Lin   +16 more
doaj   +1 more source

Structural basis of the chiral selectivity of Pseudomonas cepacia lipase [PDF]

, 1998
To investigate the enantioselectivity of Pseudomonas cepacia lipase, inhibition studies were performed with SC- and RC-(RP,SP)-1,2-dialkylcarbamoylglycero-3-O-p-nitrophenyl alkylphosphonates of different alkyl chain lengths. P.
Dijkstra, Bauke W.,, Haas, Gerard H. de,, Lang, Dietmar A.,, Mannesse, Maurice L.M.,, Verheij, Hubertus M.,   +4 more
core   +2 more sources

Asymmetric synthesis of γ-chloro-α,β-diamino- and β,γ-aziridino-α-aminoacylpyrrolidines and -piperidines via stereoselective Mannich-type additions of N-(diphenylmethylene)glycinamides across α-chloro-N-sulfinylimines [PDF]

, 2012
The asymmetric synthesis of new chiral gamma-chloro-alpha,beta-diaminocarboxylamide derivatives by highly diastereoselective Mannich-type reactions of N-(diphenylmethylene) glycinamides across chiral alpha-chloro-N-p-toluenesulfinylaldimines was ...
Augustyns, Koen, Callebaut, Gert, De Kimpe, Norbert, Mangelinckx, Sven, Tornroos, Karl W, Van der Veken, Pieter   +5 more
core   +3 more sources