Results 31 to 40 of about 27,319 (289)

Stereoselective arene formation [PDF]

Chemical Society Reviews, 2018
The common perception of arenes as flat and symmetric entities is juxtaposed to the counterintuitive circumstance that stereoselective arene formation offers a means to prepare an exceptional range of chiral aromatic structures in isomerically enriched form.
Achim Link, Christof Sparr
openaire   +3 more sources

Significance and challenges of stereoselectivity assessing methods in drug metabolism

Journal of Pharmaceutical Analysis, 2016
Stereoselectivity in drug metabolism can not only influence the pharmacological activities, tolerability, safety, and bioavailability of drugs directly, but also cause different kinds of drug–drug interactions.
Zhuowei Shen, Chuang Lv, Su Zeng
doaj   +1 more source

Functional Characterization and Structural Insights Into Stereoselectivity of Pulegone Reductase in Menthol Biosynthesis

Frontiers in Plant Science, 2021
Monoterpenoids are the main components of plant essential oils and the active components of some traditional Chinese medicinal herbs like Mentha haplocalyx Briq., Nepeta tenuifolia Briq., Perilla frutescens (L.) Britt and Pogostemin cablin (Blanco) Benth.
Chanchan Liu, Chanchan Liu, Qiyu Gao, Zhuo Shang, Jian Liu, Siwei Zhou, Jingjie Dang, Licheng Liu, Iris Lange, Narayanan Srividya, B. Markus Lange, Qinan Wu, Qinan Wu, Wei Lin, Wei Lin, Wei Lin, Wei Lin   +16 more
doaj   +1 more source

Stereoselectivity in Aldol Reactions of Chiral N-Acyl Selones

, 2016
Stereoselectivity in Aldol Reactions of Chiral N-Acyl ...
Ruilian Wu (1549717), Zizhong Li (130912), Ryszard Michalczyk (1479718), R. Bruce Dunlap (3008181), Louis A. “Pete” Silks (1660075), Jerome D. Odom (2972913)   +5 more
core   +4 more sources

Stereoselectivity in Cell Uptake by SLC22 Organic Cation Transporters 1, 2, and 3

, 2023
Stereoselectivity can be most relevant in drug metabolism and receptor binding. Although drug membrane transport might be equally important for small-molecule pharmacokinetics, the extent of stereoselectivity in membrane transport is largely unknown ...
Ole Jensen (268395), Muhammad Rafehi (3878050), Jürgen Brockmöller (7815518), Lukas Gebauer (10006598)   +3 more
core   +2 more sources

Stereoselectivity Switch in the Reduction of α-Alkyl-β-Arylenones by Structure-Guided Designed Variants of the Ene Reductase OYE1

Frontiers in Bioengineering and Biotechnology, 2019
Ene reductases from the Old Yellow Enzyme (OYE) family are industrially interesting enzymes for the biocatalytic asymmetric reduction of alkenes. To access both enantiomers of the target reduced products, stereocomplementary pairs of OYE enzymes are ...
Michele Crotti, Fabio Parmeggiani, Erica Elisa Ferrandi, Francesco G. Gatti, Alessandro Sacchetti, Sergio Riva, Elisabetta Brenna, Daniela Monti   +7 more
doaj   +1 more source

Revisiting the Stereoselectivity in Organoborane Rearrangement

, 2022
Hydroboration of 1,2-dimethylcyclohexene (A) and successive rearrangements yield not only tertiary alkylboranes but also primary and secondary ones. In addition, nontypical anti-addition products are detected, whose formation mechanism is not apparent ...
Gabriel, Merino, Fernando, Murillo, Alan, Quintal, María A., Fernández-Herrera, Jair, García-Méndez, Eugenia, Dzib   +5 more
core   +1 more source

Stereoselective Radical Translocations

CHIMIA, 2008
The stereochemical outcome of intramolecular radical mediated hydrogen transfer (= radical translocation) is discussed. Low to excellent levels of stereocontrol are observed making such processes attractive for applications in target-oriented synthesis.
Renaud, Philippe, Beaufils, Florent, Dénès, Fabrice, Feray, Laurence, Imboden, Christoph, Kuznetsov, Nikolai   +5 more
openaire   +6 more sources

Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine

Journal of Chemistry, 2017
Abuse of 3,4-methylenedioxymethamphetamine (MDMA) is becoming more common worldwide. To date, there is no information available on stereoselectivity of MDMA protein binding in humans, rats, and mice.
Wan Raihana Wan Aasim, Soo Choon Tan, Siew Hua Gan   +2 more
doaj   +1 more source

Predicting glycosylation stereoselectivity using machine learning

, 2021
Predicting the stereochemical outcome of chemical reactions is challenging in mechanistically ambiguous transformations. The stereoselectivity of glycosylation reactions is influenced by at least eleven factors across four chemical participants and ...
Gilmore, Kerry, Chatterjee, S., Chatterjee, Sourav, Moon, S., Gilmore, K., Moon, Sooyeon, Seeberger, Peter H., Seeberger, P.   +7 more
core   +1 more source