Results 31 to 40 of about 30,863 (282)

The Synthesis of α-Aminophosphonates via Enantioselective Organocatalytic Reaction of 1-(N-Acylamino)alkylphosphonium Salts with Dimethyl Phosphite

Molecules, 2020
α-Aminophosphonic acids are phosphorus analogues of α-amino acids. Compounds of this type find numerous applications in medicine and crop protection due to their unique biological activities.
Alicja Walęcka-Kurczyk, Krzysztof Walczak, Anna Kuźnik, Sebastian Stecko, Agnieszka Październiok-Holewa   +4 more
doaj   +1 more source

Functional Characterization and Structural Insights Into Stereoselectivity of Pulegone Reductase in Menthol Biosynthesis

Frontiers in Plant Science, 2021
Monoterpenoids are the main components of plant essential oils and the active components of some traditional Chinese medicinal herbs like Mentha haplocalyx Briq., Nepeta tenuifolia Briq., Perilla frutescens (L.) Britt and Pogostemin cablin (Blanco) Benth.
Chanchan Liu, Chanchan Liu, Qiyu Gao, Zhuo Shang, Jian Liu, Siwei Zhou, Jingjie Dang, Licheng Liu, Iris Lange, Narayanan Srividya, B. Markus Lange, Qinan Wu, Qinan Wu, Wei Lin, Wei Lin, Wei Lin, Wei Lin   +16 more
doaj   +1 more source

Stereoselectivity in Cell Uptake by SLC22 Organic Cation Transporters 1, 2, and 3

, 2023
Stereoselectivity can be most relevant in drug metabolism and receptor binding. Although drug membrane transport might be equally important for small-molecule pharmacokinetics, the extent of stereoselectivity in membrane transport is largely unknown ...
Ole Jensen (268395), Muhammad Rafehi (3878050), Jürgen Brockmöller (7815518), Lukas Gebauer (10006598)   +3 more
core   +2 more sources

Significance and challenges of stereoselectivity assessing methods in drug metabolism

Journal of Pharmaceutical Analysis, 2016
Stereoselectivity in drug metabolism can not only influence the pharmacological activities, tolerability, safety, and bioavailability of drugs directly, but also cause different kinds of drug–drug interactions.
Zhuowei Shen, Chuang Lv, Su Zeng
doaj   +1 more source

Stereoselectivity Switch in the Reduction of α-Alkyl-β-Arylenones by Structure-Guided Designed Variants of the Ene Reductase OYE1

Frontiers in Bioengineering and Biotechnology, 2019
Ene reductases from the Old Yellow Enzyme (OYE) family are industrially interesting enzymes for the biocatalytic asymmetric reduction of alkenes. To access both enantiomers of the target reduced products, stereocomplementary pairs of OYE enzymes are ...
Michele Crotti, Fabio Parmeggiani, Erica Elisa Ferrandi, Francesco G. Gatti, Alessandro Sacchetti, Sergio Riva, Elisabetta Brenna, Daniela Monti   +7 more
doaj   +1 more source

Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine

Journal of Chemistry, 2017
Abuse of 3,4-methylenedioxymethamphetamine (MDMA) is becoming more common worldwide. To date, there is no information available on stereoselectivity of MDMA protein binding in humans, rats, and mice.
Wan Raihana Wan Aasim, Soo Choon Tan, Siew Hua Gan   +2 more
doaj   +1 more source

Stereoselective Radical Translocations

CHIMIA, 2008
The stereochemical outcome of intramolecular radical mediated hydrogen transfer (= radical translocation) is discussed. Low to excellent levels of stereocontrol are observed making such processes attractive for applications in target-oriented synthesis.
Renaud, Philippe, Beaufils, Florent, Dénès, Fabrice, Feray, Laurence, Imboden, Christoph, Kuznetsov, Nikolai   +5 more
openaire   +6 more sources

Stereoselectivity of the Thia-Sommelet [2,3]-Dearomatization

, 2016
Stereoselectivity of the Thia-Sommelet [2,3 ...
Richard Berger (1417021), David L. Van Vranken (1491034), Joseph W. Ziller (1340067)   +2 more
core   +2 more sources

Stereoselectivity in Polyphenol Biosynthesis [PDF]

, 1992
Stereoselectivity plays an important role in the late stages of phenyl-propanoid metabolism, affording lignins, lignans, and neolignans. Stereoselectivity is manifested during monolignol (glucoside) synthesis, e.g., where the geometry (E or Z) of the ...
Norman G. Lewis, Lewis, Norman G., Davin, Laurence B., Laurence B. Davin   +3 more
core   +1 more source

Photothermal conversion triggered thermal asymmetric catalysis within metal nanoparticles loaded homochiral covalent organic framework

Nature Communications, 2019
Achieving both high stereoselectivity and yield is a challenge for conventional asymmetric catalysis. Here, the authors report two metal nanoparticle-loaded and porphyrin-containing homochiral covalent organic framework-based composite catalysts that ...
Hui-Chao Ma, Chen-Chen Zhao, Gong-Jun Chen, Yu-Bin Dong   +3 more
doaj   +1 more source