Results 41 to 50 of about 27,319 (289)
Nature Communications, 2019 Achieving both high stereoselectivity and yield is a challenge for conventional asymmetric catalysis. Here, the authors report two metal nanoparticle-loaded and porphyrin-containing homochiral covalent organic framework-based composite catalysts that ...
Hui-Chao Ma +3 more
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The Stereoselectivity of Drug Action [PDF]
Pharmacology & Toxicology, 1989 Pharmacologists and toxicologists are in the midst of demonstrating the importance of spatial (three-dimensional) molecular features in the functions of biological systems and in the therapeutic actions and side effects of drugs. Recent findings indicate that spatial features in a variety of biologically active molecules play a decisive role in many ...
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Synthesis and 1,3-Dipolar Cycloaddition Reactions of Chiral Maleimides
Molecules, 1997 New routes to the synthesis of various novel chiral maleimides are described. The oxabicyclic anhydride 2 readily available exo-Diels-Alder adduct of furan and maleic anhydride was used as a vehicle, which in turn reacted with hydrochlorides of amino ...
Lubor Fisera, Vladimir Ondrus
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Recent Advances of Pharmaceutical Process Chemistry and Its Innovation in China: Part 1
Pharmaceutical Fronts, 2020 This review article summarizes recent developments and innovations in China's pharmaceutical process chemistry over the last several decades. Case studies of dozens of blockbuster drug processes are presented, including bulk drugs, such as the over-the ...
Pei Tang +5 more
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Molecules, 2022 Herein the reaction mechanism and the origin of stereoselectivity of asymmetric hydrogenation of oximes to hydroxylamines catalyzed by the cyclometalated iridium (III) complexes with chiral substituted single cyclopentadienyl ligands (Ir catalysts A1 and
Qaim Ali +6 more
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Stereoselectivity of the Thia-Sommelet [2,3]-Dearomatization
, 2016 Stereoselectivity of the Thia-Sommelet [2,3 ...
Richard Berger (1417021) +2 more
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, 2023 Bedaquiline (BDQ) is an important drug for treating multidrug-resistant tuberculosis (MDR-TB), a worldwide disease that causes more than 1.6 million deaths yearly.
Gopal, Sirasani +14 more
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Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview
Molecules, 2011 Uronic acids are carbohydrates present in relevant biologically active compounds. Most of the latter are glycosides or oligosaccharides linked by their anomeric carbon, so their synthesis requires glycoside-bond formation. The activation of this anomeric
José Kovensky, Anne Wadouachi
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Molecules, 2023 Pioglitazone, a PPAR-gamma activator used to diagnose hyperglycemia, was studied for its stereoselective deposition and active enantiomers in female albino Wistar rats.
Tatineni Spandana +8 more
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A stereoselective synthesis of (+)-boronolide [PDF]
Tetrahedron Letters, 2000 A stereoselective synthesis of (+)-boronolide is described. The key steps involve a stereoselective reduction of an α-hydroxy ketone, allylation of an α-hydroxy aldehyde and a ring-closing olefin metathesis of a homoallylic alcohol derived acrylate ester utilizing Grubbs' catalyst.
Arun K, Ghosh, Geoffrey, Bilcer
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