Results 71 to 80 of about 30,863 (282)

Isothiazologuanosine (tzG) as Environmentally Sensitive Fluorescent Reporter in RNA

Angewandte Chemie, EarlyView.
The emissive isothiazologuanosine analog tzG is synthesized for the first time as RNA phosphoramidite building block for solid‐phase synthesis. Due to its isomorphic and isofunctional characteristics, tzG forms Watson–Crick base pairs and can be used as fluorescent probe to monitor (deoxy)ribozyme activity.
Julia Dietzsch, Yitzhak Tor, Claudia Höbartner   +2 more
wiley   +2 more sources

Natural Product Ginsenoside 20(S)-25-Methoxyl-Dammarane-3β, 12β, 20-Triol in Cancer Treatment: A Review of the Pharmacological Mechanisms and Pharmacokinetics

Frontiers in Pharmacology, 2020
Panax ginseng has been used as an herbal medicine for thousands of years. Most of its pharmacological effects are attributed to its constituent ginsenosides, including 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(S)-25-OCH3-PPD), which is one of the
Dohyun Kim, Minwoo Park, Iqra Haleem, Younghong Lee, Jain Koo, Young Chae Na, Gidong Song, Jaehwi Lee   +7 more
doaj   +1 more source

Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

Beilstein Journal of Organic Chemistry, 2021
Sugar-modified nucleosides have gained considerable attention in the scientific community, either for use as molecular probes or as therapeutic agents. When the methylene group of the ribose ring is replaced with a sulfur atom at the 3’-position, these ...
Umesh P. Aher, Dhananjai Srivastava, Girij P. Singh, Jayashree B. S   +3 more
doaj   +1 more source

Stereoselective Synthesis of Baulamycin A

The Journal of Organic Chemistry, 2020
New structural classes of antibiotics are rare, structurally novel broad-spectrum antibiotics exceptionally so. The recently discovered baulamycins constitute a remarkable example of these highly prized compounds and, as such, have attracted considerable attention in the form of both synthetic efforts and biological studies.
Jonathan R. Thielman, David H. Sherman, Robert M. Williams   +2 more
openaire   +3 more sources

Dual Nickel/Photoredox‐Catalyzed Regio‐ and Enantioselective Alkenylation of Epoxides

Advanced Science, EarlyView.
Ni/photoredox‐catalyzed stereoconvergent cross‐electrophile coupling of racemic epoxides with alkenyl bromides is described, affording β‐alkenyl products with up to 95% ee, excellent E‐selectivity, and complete regiocontrol. These versatile intermediates enable diverse chiral synthons; mechanistic studies suggest a halide ring‐opening followed by ...
Hongyan Lan, Shengzhou Jin, Zhao‐Dong Xu, Guigen Li, Dingyi Wang   +4 more
wiley   +1 more source

Synergistic Silylium‐Ion and Palladium Catalysis Enables Migratory Alkene Silylation With Allylsilanes by Formal C–H/C–Si Metathesis

Angewandte Chemie, EarlyView.
Merging silylium‐ion and palladium catalysis provides a mechanistically distinct route to allylsilanes by formal C–H/Si–H metathesis. Using allylsilanes as silicon proelectrophiles, various allylarenes undergo migrative silylation, selectively yielding (E)‐allylsilanes.
Longhui Duan, Zheng‐Wang Qu, Stefan Grimme, Elisabeth Irran, Hendrik F. T. Klare, Martin Oestreich   +5 more
wiley   +2 more sources

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

1,3‐Brook Rearrangement of α‐Silyl Allylic Alcohols: Copper‐Catalyzed Enantiospecific Formation of Allenes and Copper‐Mediated ipso‐Substitution Reactions Affording Trisubstituted Alkenes

Angewandte Chemie, EarlyView.
A regioselective ruthenium catalyzed trans‐hydrosilylation of propargyl alcohols followed by a 1,3‐Brook rearrangement opens access to reactive organocopper intermediates, which evolve upon warming into allenes with strict chirality transfer to the emerging axis; alternatively, these reactive species can be trapped with a large variety of electrophiles
Jack L. Sutro, Felix Anderl, Paul Haf‐Moths, Alois Fürstner   +3 more
wiley   +2 more sources

Synthetic explorations of the briarane jungle: progress in developing a synthetic route to a common family of diterpenoid natural products [PDF]

Royal Society Open Science, 2018
The briarane diterpenoids are a large family of marine natural products that have been primarily isolated from gorgonian octocorals around the world.
Nicholas G. Moon, Andrew M. Harned
doaj   +1 more source

Intramolecular Nickel‐Catalyzed Reductive Coupling: Enantioselective Synthesis of Tetrahydroisoquinolines and Related Heterocycles

Angewandte Chemie, EarlyView.
The successful extension of the nickel‐catalyzed asymmetric coupling of polarized 1,3‐dienes with aldehydes to an intramolecular setting opens an efficient new entry into hydroxylated N‐heterocyclic compounds, most notably valuable tetrahydroisoquinolines.
Thilo Bender, Markus Leutzsch, Yannik Sell, Alois Fürstner   +3 more
wiley   +2 more sources