Results 71 to 80 of about 14,639 (100)

Stereoselective synthesis of microcarpalide

Tetrahedron, 2005
Microcarpalide is a strong microfilament disrupting agent. The convergent and stereoselective synthesis of microcarpalide was succeeded via Julia olefination and macrolactonization.
Ken Ishigami, Hidenori Watanabe, Takeshi Kitahara   +2 more
openaire   +1 more source

Stereoselective Synthesis of (+)-Goniothalesdiol

The Journal of Organic Chemistry, 2006
Stereoselective synthesis of antitumor tetrahydrofuran (+)-goniothalesdiol was achieved in high overall yield from (-)-D-tartaric acid. Key features include an FeCl3 mediated THF formation with very high selectivity. Synthesis of natural gonithalesdiol and its analogue 2,5-bis-epi-goniothalesdiol was achieved from a common intermediate.
Prasad, Kavirayani R, Gholap, Shivajirao L   +1 more
openaire   +2 more sources

A Stereoselective Synthesis of Lentiginosine

The Journal of Organic Chemistry, 2016
A concise stereoselective synthesis of (-)-lentiginosine, an iminosugar endowed with an interesting proapoptotic activity, has been accomplished using an enantiopure pyrroline N-oxide building block derived from d-tartaric acid. Key steps are a totally diastereoselective nucleophilic addition to the cyclic nitrone followed by a combination of two ...
CORDERO, FRANCA MARIA, VURCHIO, CAROLINA, BRANDI, ALBERTO   +2 more
openaire   +3 more sources

Stereoselective pharmacokinetics of perhexiline

Xenobiotica, 1986
Blood plasma and urine excretion pharmacokinetics of the (+) and (-) enantiomers of perhexiline have been determined in oral single-dose studies in eight human volunteers, and compared with the pharmacokinetics of the racemate drug in the same subjects. The (-) enantiomer is more rapidly metabolized and eliminated, and is stereoselectively hydroxylated
B J, Gould, A G, Amoah, D V, Parke
openaire   +2 more sources

Stereoselective Synthesis of (+)-Boronolide

The Journal of Organic Chemistry, 2002
The delta-lactone boronolide (+)-1, a pharmacologically active, naturally occurring product, has been synthesized in enantiopure form with L-erythrulose as the chiral starting material. The key steps of the synthesis were a highly stereoselective aldol-reduction one-pot sequence, an indium-mediated diastereoselective aldehyde allylation, and a ring ...
Miguel, Carda, Santiago, Rodríguez, Beatriz, Segovia, J Alberto, Marco   +3 more
openaire   +2 more sources

Stereoselectivity in drug metabolism

Expert Opinion on Drug Metabolism & Toxicology, 2007
Many chiral drugs are used as their racemic mixtures in clinical practice. Two enantiomers of a chiral drug generally differ in pharmacodynamic and/or pharmacokinetic properties as a consequence of the stereoselective interaction with optically active biological macromolecules.
openaire   +2 more sources

Stereoselective synthesis of anamarine

Tetrahedron, 2004
A stereoselective synthesis of the naturally occurring, α,β-unsaturated lactone anamarine is described. The key step was a highly stereoselective aldol reaction of a protected erythrulose derivative with a chiral aldehyde. Another relevant step was an asymmetric aldehyde allylation with a chiral allylborane. The lactone ring was made by means of a ring-
Santiago Diaz‐Oltra, Juan Murga, Eva Falomir, Miguel Carda, J. Alberto Marco   +4 more
openaire   +1 more source

Isoflurane anesthesia is stereoselective

European Journal of Pharmacology, 1992
The anesthetic effects of the (+) and (-) isomers of isoflurane were determined in mice. Like the clinically important racemate, both isomers produced dose-dependent increases in anesthetic sleep time. A statistically significant (P less than 0.005, ANOVA) difference in the potencies of these isomers ((+) greater than (-)) was observed.
B, Harris, E, Moody, P, Skolnick
openaire   +2 more sources

Stereoselective Synthesis of (+)-Aspidofractinine

The Journal of Organic Chemistry, 2009
We describe the synthesis of (+)-aspidofractinine, the enantiomer of a naturally occurring alkaloid of the kopsane family. Key features of the synthesis include a stereospecific cyanate to isocyanate rearrangement on a chiral scaffold, a ring-closing alkene metathesis to cleave the chiral auxiliary, and a chemoselective cyclopropanation to introduce ...
David, Gagnon, Claude, Spino
openaire   +2 more sources

Stereoselective synthesis of (.+-.)-cyanocycline

Journal of the American Chemical Society, 1986
D A, Evans, C R, Illig, J C, Saddler
openaire   +2 more sources