Results 41 to 50 of about 11,302,873 (322)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Six-Dimensional Quantum Dynamics of Adsorption and Desorption of H_2 at Pd(100): No Need for a Molecular Precursor Adsorption State

, 1996
We report six-dimensional quantum dynamical calculations of dissociative adsorption and associative desorption of the system H_2/Pd(100) using an ab-initio potential energy surface.
Alnot, Axel Gross, Berger, Beutl, Blaha, Brenig, Brenig, Brunner, Butler, Butler, Chiba, Dai, Dai, Darling, Darling, Darling, Darling, Darling, Darling, Dixon-Warren, Engdahl, Gross, Gross, Gross, Halstead, Hammer, Holloway, Jackson, Kohler, Kumar, Küchenhoff, Matthias Scheffler, Michelsen, Mowrey, Perdew, Rendulic, Rendulic, Resch, Rettner, Schröter, Schröter, Steffen Wilke, White, Wilke, Wilke, Zangwill   +45 more
core   +1 more source

What drives amyloid molecules to assemble into oligomers and fibrils? [PDF]

, 2010
We develop a general theory for three states of equilibrium of amyloid peptides: the monomer, oligomer, and fibril. We assume that the oligomeric state is a disordered micelle-like collection of a few peptide chains held together loosely by hydrophobic ...
Ahmad, Auer, Bitan, Chen, Chimon, Conway, Dill, Dill, Dill, Dobson, DuBay, Fernandez-Escamilla, Ghosh, Ghosh, Glabe, Hall, Hamada, Hardy, Jarrett, Jeremy D. Schmit, Kashchiev, Ken Dill, Kim, Kingshuk Ghosh, Klement, Knowles, Lashuel, Lee, Lee, Lifson, Lührs, Modler, Nelson, Pallitto, Petkova, Petkova, Poland, Powers, Sawaya, Schellmann, Serio, Sillero, Tartaglia, Terzi, Tiana, Trovato, van Gestel, van Gestel, van Raaij, Wang, Wasmer, Wolf, Yong, Zhang, Zimm   +54 more
core   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Stratification relieves constraints from steric hindrance in the generation of compact acto-myosin asters at the membrane cortex [PDF]

, 2020
Recent in-vivo studies have revealed that several membrane proteins are driven to form nanoclusters by active contractile flows arising from F-actin and myosin at the cortex. The mechanism of clustering was shown to be arising from the dynamic patterning
Bhat, Abrar, Das, Amit, Koster, Darius, Mayor, Satyajit, Rao, Madan, Sknepnek, Rastko   +5 more
core   +3 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Carbon monoxide binding to iron porphyrins [PDF]

, 1979
The carbon monoxide affinities of iron complexes of meso-tetra (α,α,α,α-o-pivalamidophenyl)porphyrin (the "picket fence" porphyrin) and of a "picket fence" porphyrin derivative with an appended axial base have been measured in solution and compared with ...
Brauman, John I., Collman, James P., Doxsee, Kenneth M.   +2 more
core   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

In silico geometric and energetic data of all possible simple rotamers made of non-metal elements

Data in Brief, 2020
This article presents theoretical data on geometric and energetic features of halogenated rotamers of the following backbone structures, CC, NN, PP, OO, SS, NP, OS, CN, CP, CO, CS, NO, NS, PO and PS.
Taweetham Limpanuparb, Sopanant Datta, Kridtin Chinsukserm, Peerayar Teeraniramitr   +3 more
doaj