Unexpected steric hindrance failure in the gas phase F− + (CH3)3CI SN2 reaction [PDF]
Nature Communications, 2022 Base-induced elimination (E2) and bimolecular nucleophilic substitution (SN2) are of significant importance in physical organic chemistry. Here, the authors show that the competing factor of E2 as opposed to steric hindrance determines the low reactivity
Xiaoxiao Lu +6 more
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Stratification relieves constraints from steric hindrance in the generation of compact actomyosin asters at the membrane cortex. [PDF]
Sci Adv, 2020 Recent in-vivo studies have revealed that several membrane proteins are driven to form nanoclusters by active contractile flows arising from F-actin and myosin at the cortex. The mechanism of clustering was shown to be arising from the dynamic patterning
Das A +5 more
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Dual-targeting and steric hindrance resolution in HER2 IHC: a novel approach to improve diagnostic sensitivity [PDF]
BMC CancerBackground The HER2 immunohistochemistry (IHC) test is an essential method for detecting breast cancer (BC) and plays a pivotal role in guiding personalized treatment strategies.
Li Luo +8 more
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Quantifying steric hindrance and topological obstruction to protein structure superposition [PDF]
Algorithms for Molecular Biology, 2021 Background In computational structural biology, structure comparison is fundamental for our understanding of proteins. Structure comparison is, e.g., algorithmically the starting point for computational studies of structural evolution and it guides our ...
Peter Røgen
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Increasing Specificity of Targeted DNA Methylation Editing by Non-Enzymatic CRISPR/dCas9-Based Steric Hindrance [PDF]
Biomedicines, 2023 As advances in genome engineering inch the technology towards wider clinical use—slowed by technical and ethical hurdles—a newer offshoot, termed “epigenome engineering”, offers the ability to correct disease-causing changes in the DNA without changing ...
Daniel M. Sapozhnikov, Moshe Szyf
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Bulky-Yet-Flexible Carbene Ligands and Their Use in Palladium Cross-Coupling [PDF]
Inorganics, 2019 In recent years, several classes of new N-heterocyclic carbene (NHC) ligands were developed around the concept of “flexible steric bulk”. The steric hindrance of these ligands brings stability to the active species, while ligand flexibility ...
Sofie M. P. Vanden Broeck +2 more
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Investigating the Influence of Steric Hindrance on Selective Anion Transport [PDF]
Molecules, 2019 A series of symmetrical and unsymmetrical alkyl tren based tris-thiourea anion transporters were synthesised and their anion binding and transport properties studied.
Laura A. Jowett +4 more
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A molecular equation of state for alcohols which includes steric hindrance in hydrogen bonding [PDF]
, 2018 In this paper we develop the first equation of state for alcohol containing mixtures which includes the effect of steric hindrance between the two electron lone pair hydrogen bond acceptor sites on the alcohol's hydroxyl oxygen. The theory is derived for
Marshall, Bennett D.
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Steric Hindrance Drives the Boron-Initiated Polymerization of Dienyltriphenylarsonium Ylides to Photoluminescent C5-Polymers. [PDF]
Angew Chem Int Ed Engl, 2021 Wang X, Hadjichristidis N.
europepmc +3 more sources
Does Steric Hindrance Actually Govern the Competition between Bimolecular Substitution and Elimination Reactions? [PDF]
J Phys Chem A, 2022 Gallegos M +2 more
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