Stratification relieves constraints from steric hindrance in the generation of compact actomyosin asters at the membrane cortex. [PDF]
Sci Adv, 2020 Recent in-vivo studies have revealed that several membrane proteins are driven to form nanoclusters by active contractile flows arising from F-actin and myosin at the cortex. The mechanism of clustering was shown to be arising from the dynamic patterning
Das A +5 more
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Investigating the Influence of Steric Hindrance on Selective Anion Transport [PDF]
Molecules, 2019 A series of symmetrical and unsymmetrical alkyl tren based tris-thiourea anion transporters were synthesised and their anion binding and transport properties studied.
Laura A. Jowett +4 more
doaj +8 more sources
Pan-H7 influenza human antibody virus neutralization depends on avidity and steric hindrance [PDF]
JCI InsightH7N9 avian influenza virus is a zoonotic influenza virus of public health concern, with a 39% mortality rate in humans. H7N9-specific prevention or treatments for humans have not been approved.
Iuliia M. Gilchuk +9 more
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Quantifying steric hindrance and topological obstruction to protein structure superposition [PDF]
Algorithms for Molecular Biology, 2021 Background In computational structural biology, structure comparison is fundamental for our understanding of proteins. Structure comparison is, e.g., algorithmically the starting point for computational studies of structural evolution and it guides our ...
Peter Røgen
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Increasing Specificity of Targeted DNA Methylation Editing by Non-Enzymatic CRISPR/dCas9-Based Steric Hindrance [PDF]
Biomedicines, 2023 As advances in genome engineering inch the technology towards wider clinical use—slowed by technical and ethical hurdles—a newer offshoot, termed “epigenome engineering”, offers the ability to correct disease-causing changes in the DNA without changing ...
Daniel M. Sapozhnikov, Moshe Szyf
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Bulky-Yet-Flexible Carbene Ligands and Their Use in Palladium Cross-Coupling [PDF]
Inorganics, 2019 In recent years, several classes of new N-heterocyclic carbene (NHC) ligands were developed around the concept of “flexible steric bulk”. The steric hindrance of these ligands brings stability to the active species, while ligand flexibility ...
Sofie M. P. Vanden Broeck +2 more
doaj +3 more sources
Unexpected steric hindrance failure in the gas phase F− + (CH3)3CI SN2 reaction [PDF]
Nature Communications, 2022 Base-induced elimination (E2) and bimolecular nucleophilic substitution (SN2) are of significant importance in physical organic chemistry. Here, the authors show that the competing factor of E2 as opposed to steric hindrance determines the low reactivity
Xiaoxiao Lu +6 more
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Dual-targeting and steric hindrance resolution in HER2 IHC: a novel approach to improve diagnostic sensitivity [PDF]
BMC CancerBackground The HER2 immunohistochemistry (IHC) test is an essential method for detecting breast cancer (BC) and plays a pivotal role in guiding personalized treatment strategies.
Li Luo +8 more
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Herbicidal Activity of Carbamoylimidazoles with Steric Hindrance
Journal of Pesticide Science, 1988 ある種のアゾール化合物が, 植物成長調節作用を示すことに着目し, 1,2,3,4-テトラヒドロキノリン, 1,2-ジヒドロキノリン, ベンゾモルホリンおよび1,2,3,4-テトラヒドロ-2-キノキサリノンから導かれる種々のカルバモイルイミダゾールを合成し, タイヌビエに対する除草活性を調べた. 本系統化合物においては, 置換基が, 除草活性発現に重要であり, とくに, カルバモイルイミダゾール結合部位で込み入った構造となっている時に, 除草活性が強化されることが判明した. 試験化合物中, 良好な除草活性を示したN-(2,2-ジメチル-6-クロロ-1,2,3,4-テトラヒドロキノリン) カルボニルイミダゾールは, タイヌビエのみならず, 広葉雑草, マツバイ, ホタルイにも除草活性を示し ...
Tadashi Ohsumi +3 more
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Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide. [PDF]
Nucleic Acids Res, 2023 Troisi R +8 more
europepmc +3 more sources